13 research outputs found

    The portfolio implications of home ownership

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    Also available via the InternetAvailable from British Library Document Supply Centre-DSC:3597.9512(no 3501) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    Witwassen

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    As a result of the signing of international treaties and regulations, the fight against money laundering in the Netherlands became official in 1993. So where do we stand now, more than twelve years after we first started to combat money laundering? This question lies at the heart of this themed issue. Six articles present an image of the nature and scope of money laundering in the Netherlands, the penalisation, the confiscation of criminal profits and the new opportunities for prevention. In addition, the issue looks at the real estate sector, which features prominently in the money laundering activities

    The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

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    The accumulation and toxicity of the weak base doxorubicin has been investigated as a function of extracellular pH, intracellular pH and the cellular pH gradient in cells previously cultured under normal (pH 7.4) and low-pH (6.8) conditions. Low-pH-adapted cells exhibit transmembrane pH gradients which substantially differ from normal cells at the same extracellular pH. No relationship was obtained between intracellular pH and the uptake or toxicity of doxorubicin in the two cell types. In contrast, doxorubicin accumulation and toxicity increased with increasing extracellular pH in both normal and low-pH-adapted cells. However, at the same extracellular pH, drug cytotoxicity was more pronounced in normal than in low-pH-adapted cells. The difference in doxorubicin accumulation and cytotoxicity at the same extracellular pH was found to be dependent on the difference in the transmembrane pH gradient of the two cell types. As the cellular pH gradient differs between tumour and normal tissue, this observation suggests a basis for enhancing cellular drug uptake in either tissue type. © 1999 Cancer Research Campaig
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