4 research outputs found
A causal inference study: The impact of the combined administration of Donepezil and Memantine on decreasing hospital and emergency department visits of Alzheimer’s disease patients
Alzheimer’s disease is the most common type of dementia that currently affects over 6.5 million people in the U.S. Currently there is no cure and the existing drug therapies attempt to delay the mental decline and improve cognitive abilities. Two of the most commonly prescribed such drugs are Donepezil and Memantine. We formally tested and confirmed the presence of a beneficial drug-drug interaction of Donepezil and Memantine using a causal inference analysis. We applied doubly robust estimators to one of the largest and high-quality medical databases to estimate the effect of two commonly prescribed Alzheimer’s disease (AD) medications, Donepezil and Memantine, on the average number of hospital or emergency department visits per year among patients diagnosed with AD. Our results show that, compared to the absence of medication scenario, the Memantine monotherapy, and the Donepezil monotherapy, the combined use of Donepezil and Memantine treatment significantly reduces the average number of hospital or emergency department visits per year by 0.078 (13.8%), 0.144 (25.5%), and 0.132 days (23.4%), respectively. The assessed decline in the average number of hospital or emergency department visits per year is consequently associated with a substantial reduction in medical costs. As of 2022, according to the Alzheimer’s Disease Association, there were over 6.5 million individuals aged 65 and older living with AD in the US alone. If patients who are currently on no drug treatment or using either Donepezil or Memantine alone were switched to the combined used of Donepezil and Memantine therapy, the average number of hospital or emergency department visits could decrease by over 613 thousand visits per year. This, in turn, would lead to a remarkable reduction in medical expenses associated with hospitalization of AD patients in the US, totaling over 940 million dollars per year
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A collective approach to reducing carbon dioxide emission: A case study of four University of Lagos Halls of residence
A major focus of existing literature on energy conservation is the modelling and quantification of energy savings and the corresponding carbon dioxide emissions from lightings. While many studies have established theoretical frameworks concerning these issues, very little documentation exists relating to energy savings and emission levels in students’ hostels. This paper considers the lighting efficiency improvement of four University of Lagos halls of residence for the purpose of quantifying energy saving and the minimization of carbon dioxide that can be made. Compact fluorescent lamps are considered alternatives to the current primary usage of conventional fluorescent and incandescent bulbs. The existing electricity consumption data obtained from energy audit are used in combination with conversion factors to estimate the annual CO2 contributed to the atmosphere by lighting in each of the buildings. The result of the study shows that over 45% reduction in carbon dioxide emission can be achieved. There is a lot individuals can do to reduce the emissions, for example, using energy saving appliances, turning off appliances when not in use, less use of fossil fuels, are simple measures that can be adopted to reduce annual carbon footprint, improve economic growth, enhance environment, health and save the planet