It’s RAINing : Remotely Accessible Instruments in Nanotechnology to Promote Student Success

Remotely Accessible Instruments in Nanotechnology (RAIN) is a community of educators that aims to bring advanced technologies into K-12 and college classrooms via remote access. RAIN\u27s mission is to facilitate the study of nanoscale science by lowering barriers for instructors to deliver relevant educational activities for younger students interested in learning about nanotechnology across traditional STEM fields. Additionally, RAIN engages the next generation STEM workforce with a connection to experts, tools and institutions where cutting-edge research is being performed. This resource is particularly vital for underrepresented and minority students, especially those attending institutions that cannot provide on-site access to advanced technologies. Currently the RAIN network consists of ten sites across the United States and offers its services free of charge to make STEM education more accessible to the students that would otherwise not encounter these resources. Data shows that RAIN is effective at fostering a passion for the sciences when used in K-12 thru college curricula

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015

Deep water inflow slowed offshore expansion of the West Antarctic Ice Sheet at the Eocene-Oligocene transition

The stability of the West Antarctic Ice Sheet is threatened by the incursion of warm Circumpolar Deepwater which flows southwards via cross-shelf troughs towards the coast there melting ice shelves. However, the onset of this oceanic forcing on the development and evolution of the West Antarctic Ice Sheet remains poorly understood. Here, we use single- and multichannel seismic reflection profiles to investigate the architecture of a sediment body on the shelf of the Amundsen Sea Embayment. We estimate the formation age of this sediment body to be around the Eocene-Oligocene Transition and find that it possesses the geometry and depositional pattern of a plastered sediment drift. We suggest this indicates a southward inflow of deep water which probably supplied heat and, thus, prevented West Antarctic Ice Sheet advance beyond the coast at this time. We conclude that the West Antarctic Ice Sheet has likely experienced a strong oceanic influence on its dynamics since its initial formation

Ways of Introducing Nanotechnology into Your Program

This webinar, provided by the Nanotechnology Applications and Career Knowledge Support Center (NACK Center) was recorded on January 27, 2012. This webinar addressed the rising global need for skilled nanotechnology workers. Topics addressed include the importance of teaching nanotechnology, the growing demand for nanotechnology workers, and major industries and job titles within the field of nanotechnology. In addition, this webinar provided an overview of nanotechnology and resources for learning more about the subject, including resources created by NACK that are designed specifically for educators. The webinar runs 01:24:05 minutes in length and is accompanied by a 2-page handout and a slide deck. The accompanying handout provides information about the presenters, outlines key objectives of the webinar, and provides links to video resources and additional web resources.Â

Penn State CNEU: Itâs NACK Plus Moreâ¦

This video from the Micro Nano Technology Education Center (MNT-EC) is part of a series of seminars on micro nano technologies and issues in the field. In the video, Robert Ehrmann and Atilla Cakmak present on the accomplishment and future plans for the Penn State Center for Nanotechnology Education and Utilization (CNEU). This includes information on student education, educator assistance, and reaching under-served populations. The video runs 1:00:13 minutes in length.&nbsp

Slides: An Introduction to Nanotechnology

These webinar slides, made available by Maricopa Advanced Technology Education Center (MATEC), provide introductory information on nanotechnology, nanomaterials, and their uses. Topics covered include: What is Nanotechnology, Benefits of Nanotechnology, Nanomaterials, Applications, Fabrication, and more.Â

Design and Wind Tunnel Testing of Cal Poly\u27s AMELIA 10 Foot Span Hybrid Wing-Body Low Noise Cestol Aircraft

California Polytechnic Corporation, Georgia Tech Research Institute (GTRI), and DHC Engineering collaborated on a NASA NRA to develop and validate predictive capabilities for the design and performance of Cruise Efficient, Short TakeOff and Landing (CESTOL) subsonic aircraft. In addition, a large scale wind tunnel effort to validate predictive capabilities for aerodynamic performance and noise during takeoff and landing has been undertaken. The model, Advanced Model for Extreme Lift and Improved Aeroacoustics (AMELIA), was designed as a 100 passenger, N+2 generation, regional, CESTOL airliner with hybrid blended wingbody with circulation control. The model design was focused on fuelsavings and noise goals set out by the NASA N+2 definition. The AMELIA is 1/13 scale with a 10 ft wing span. PatersonLabs was chosen to build AMELIA and The National FullScale Aerodynamic Complex (NFAC) 40 ft by 80 ft wind tunnel was chosen to perform the nine week long large scale wind tunnel test in the summer of 2011