1,857 research outputs found
Absolute differential cross sections for electron-impact excitation of CO near threshold: II. The Rydberg states of CO
Absolute differential cross sections for electron-impact excitation of Rydberg states of CO have been measured from threshold to 3.7 eV above threshold and for scattering angles between 20° and 140°. Measured excitation functions for the b 3Σ+, B 1Σ+ and E 1π states are compared with cross sections calculated by the Schwinger multichannel method. The behaviour of the excitation functions for these states and for the j 3Σ+ and C 1Σ+ states is analysed in terms of negative-ion states. One of these resonances has not been previously reported
Combined investigation of water sorption on rutile (1 1 0) single crystal face: XPS vs. periodic DFT
XPS and periodic DFT calculations have been used to investigate water sorption on the TiO2 rutile (1 1 0) face. Two sets of XPS spectra were collected on the TiO2 (1 1 0) single crystal clean and previously exposed to water: the first set with photoelectrons collected in a direction parallel to the normal to the surface; and the second set with the sample tilted by 70°, respectively. This tilting procedure promotes the signals from surface species and reveals that the first hydration layer is strongly coordinated to the surface and also that, despite the fact that the spectra were recorded under ultra-high vacuum, water molecules subsist in upper hydration layers. In addition, periodic DFT calculations were performed to investigate the water adsorption process to determine if molecular and/or dissociative adsorption takes place. The first step of the theoretical part was the optimisation of a dry surface model and then the investigation of water adsorption. The calculated molecular water adsorption energies are consistent with previously published experimental data and it appears that even though it is slightly less stable, the dissociative water sorption can also take place. This assumption was considered, in a second step, on a larger surface model where molecular and dissociated water molecules were adsorbed together with different ratio. It was found that, due to hydrogen bonding stabilisation, molecular and dissociated water molecules can coexist on the surface if the ratio of dissociated water molecules is less than ≈33%. These results are consistent with previous experimental works giving a 10–25% range
NOXA as critical mediator for drug combinations in polychemotherapy
During polychemotherapy, cytotoxic drugs are given in combinations to enhance their anti-tumor effectiveness. For most drug combinations, underlying signaling mechanisms responsible for positive drug–drug interactions remain elusive. Here, we prove a decisive role for the Bcl-2 family member NOXA to mediate cell death by certain drug combinations, even if drugs were combined which acted independently from NOXA, when given alone. In proof-of-principle studies, betulinic acid, doxorubicin and vincristine induced cell death in a p53- and NOXA-independent pathway involving mitochondrial pore formation, release of cytochrome c and caspase activation. In contrast, when betulinic acid was combined with either doxorubicine or vincristine, cell death signaling changed considerably; the drug combinations clearly depended on both p53 and NOXA. Similarly and of high clinical relevance, in patient-derived childhood acute leukemia samples the drug combinations, but not the single drugs depended on p53 and NOXA, as shown by RNA interference studies in patient-derived cells. Our data emphasize that NOXA represents an important target molecule for combinations of drugs that alone do not target NOXA. NOXA might have a special role in regulating apoptosis sensitivity in the complex interplay of polychemotherapy. Deciphering the differences in signaling of single drugs and drug combinations might enable designing highly effective novel polychemotherapy regimens
Potts Model On Random Trees
We study the Potts model on locally tree-like random graphs of arbitrary
degree distribution. Using a population dynamics algorithm we numerically solve
the problem exactly. We confirm our results with simulations. Comparisons with
a previous approach are made, showing where its assumption of uniform local
fields breaks down for networks with nodes of low degree.Comment: 10 pages, 3 figure
Correlations in interacting systems with a network topology
We study pair correlations in cooperative systems placed on complex networks.
We show that usually in these systems, the correlations between two interacting
objects (e.g., spins), separated by a distance , decay, on average,
faster than . Here is the mean number of the
-th nearest neighbors of a vertex in a network. This behavior, in
particular, leads to a dramatic weakening of correlations between second and
more distant neighbors on networks with fat-tailed degree distributions, which
have a divergent number in the infinite network limit. In this case, only
the pair correlations between the nearest neighbors are observable. We obtain
the pair correlation function of the Ising model on a complex network and also
derive our results in the framework of a phenomenological approach.Comment: 5 page
Integrating HDAd5/35++ vectors as a new platform for HSC gene therapy of hemoglobinopathies
We generated an integrating, CD46-targeted, helper-dependent adenovirus HDAd5/35++ vector system for hematopoietic stem cell (HSC) gene therapy. The ∼12-kb transgene cassette included a β-globin locus control region (LCR)/promoter driven human γ-globin gene and an elongation factor alpha-1 (EF1α)-mgmtP140K expression cassette, which allows for drug-controlled increase of γ-globin-expressing erythrocytes. We transduced bone marrow lineage-depleted cells from human CD46-transgenic mice and transplanted them into lethally irradiated recipients. The percentage of γ-globin-positive cells in peripheral blood erythrocytes in primary and secondary transplant recipients was stable and greater than 90%. The γ-globin level was 10%–20% of adult mouse globin. Transgene integration, mediated by a hyperactive Sleeping Beauty SB100x transposase, was random, without a preference for genes. A second set of studies was performed with peripheral blood CD34+ cells from mobilized donors. 10 weeks after transplantation of transduced cells, human cells were harvested from the bone marrow and differentiated ex vivo into erythroid cells. Erythroid cells expressed γ-globin at a level of 20% of adult α-globin. Our studies suggest that HDAd35++ vectors allow for efficient transduction of long-term repopulating HSCs and high-level, almost pancellular γ-globin expression in erythrocytes. Furthermore, our HDAd5/35++ vectors have a larger insert capacity and a safer integration pattern than currently used lentivirus vectors
Influência da cultivar de tomateiro na ação de indutores de resistência sobre adultos de Bemisia tabaci biótipo B.
Este trabalho teve por objetivo determinar se o uso associado de cultivar e indutor de resistência a fitopatógenos pode ocasionar alta mortalidade de mosca branca.Resumo 153
Complete Break Up of Ortho Positronium (Ps)- Hydrogenic ion System
The dynamics of the complete breakup process in an Ortho Ps - He+ system
including electron loss to the continuum (ELC) is studied where both the
projectile and the target get ionized. The process is essentially a four body
problem and the present model takes account of the two centre effect on the
electron ejected from the Ps atom which is crucial for a proper description of
the ELC phenomena. The calculations are performed in the framework of Coulomb
Distorted Eikonal Approximation. The exchange effect between the target and the
projectile electron is taken into account in a consistent manner. The proper
asymptotic 3-body boundary condition for this ionization process is also
satisfied in the present model. A distinct broad ELC peak is noted in the fully
differential cross sections (5DCS) for the Ps electron corroborating
qualitatively the experiment for the Ps - He system. Both the dynamics of the
ELC from the Ps and the ejected electron from the target He+ in the FDCS are
studied using coplanar geometry. Interesting features are noted in the FDCS for
both the electrons belonging to the target and the projectile.Comment: 14 pages,7 figure
Persistence of a Continuous Stochastic Process with Discrete-Time Sampling: Non-Markov Processes
We consider the problem of `discrete-time persistence', which deals with the
zero-crossings of a continuous stochastic process, X(T), measured at discrete
times, T = n(\Delta T). For a Gaussian Stationary Process the persistence (no
crossing) probability decays as exp(-\theta_D T) = [\rho(a)]^n for large n,
where a = \exp[-(\Delta T)/2], and the discrete persistence exponent, \theta_D,
is given by \theta_D = \ln(\rho)/2\ln(a). Using the `Independent Interval
Approximation', we show how \theta_D varies with (\Delta T) for small (\Delta
T) and conclude that experimental measurements of persistence for smooth
processes, such as diffusion, are less sensitive to the effects of discrete
sampling than measurements of a randomly accelerated particle or random walker.
We extend the matrix method developed by us previously [Phys. Rev. E 64,
015151(R) (2001)] to determine \rho(a) for a two-dimensional random walk and
the one-dimensional random acceleration problem. We also consider `alternating
persistence', which corresponds to a < 0, and calculate \rho(a) for this case.Comment: 14 pages plus 8 figure
First Model-Independent Measurement of the Spin Triplet Scattering Length from Final State Interaction in the Reaction
The reaction has been measured with the
COSY-TOF detector at a beam momentum of . The polarized
proton beam enables the measurement of the beam analyzing power by the
asymmetry of the produced kaon (). This observable allows the
spin triplet scattering length to be extracted for the first time
model independently from the final-state interaction in the reaction. The
obtained value is . This value is
compatible with theoretical predictions and results from model-dependent
analyses.Comment: Revised version as accepted for publication in PR
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