2 research outputs found
Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri
Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth
Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are
used for the treatment of a variety of ailments in ethno-medicine.
Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia
barteri.
Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using
a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate
and tail flick tests.
Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however
the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema
at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic
acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction
times were not significantly different from the control in the hot plate and tail flick tests.
Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and
peripherally mediated analgesic effects
Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents
Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth
Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are
used for the treatment of a variety of ailments in ethno-medicine.
Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia
barteri.
Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using
a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate
and tail flick tests.
Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however
the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema
at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic
acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction
times were not significantly different from the control in the hot plate and tail flick tests.
Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and
peripherally mediated analgesic effects