3 research outputs found
Changes in Whey Proteome between Mediterranean and Murrah Buffalo Colostrum and Mature Milk Reflect Their Pharmaceutical and Medicinal Value
Milk represents an integrated meal for newborns; its whey protein is rich in many health beneficial components and proteins. The current study aimed to investigate the differences between colostrum and mature milk from Mediterranean and Murrah buffaloes using labeled proteomics and bioinformatics tools. In the current work, LC-MS/MS analysis led to identification of 780 proteins from which 638 were shared among three independent TMT experiments. The significantly changed proteins between the studied types were analyzed using gene ontology enrichment and KEGG pathways, and their interactions were generated using STRING database. Results indicated that immunological, muscular development and function, blood coagulation, heme related, neuronal, translation, metabolic process, and binding proteins were the main terms. Overall, colostrum showed higher levels of immunoglobulins, myosins, actin, neurofascin, syntaxins, thyroglobulins, and RNA-binding proteins, reflecting its importance in the development and activity of immunological, muscular, cardiac, neuronal, and thyroid systems, while lactoferrin and ferritin were increased in mature milk, highlighting its role in iron storage and hemoglobin formation
Recommended from our members
An updated and comprehensive review on the composition and preservation strategies of bovine colostrum and its contributions to animal health
Colostrum is the first mammary gland secretion after parturition. Colostrum has a high nutritional value due to its contents of macronutrients, micronutrients, and bioactive compounds, and colostrum intake could improve growth performance, gastrointestinal tract development, and health status. Thus, this review focuses on the nutritional composition of bovine colostrum and its health benefits on newborn calves. Until now, the main colostrum constituents that have been more studied are macronutrients such as carbohydrates, fats, proteins, and micronutrients like vitamins, minerals, and growth factors as they provide the following health benefits to calves: boost immunity, prevent infections, treat diarrhea, and promote gut health. In addition, this review focuses on studying different preservation methods for colostrum that are useful when fresh colostrum is less or unavailable. Colostrum can be preserved using different strategies, such as the use of chemical additives, pasteurization, refrigeration, freezing, freeze- and spray-drying, which can be used to preserve colostrum. On the other hand, the best preservations methods are freeze-drying, spray drying, and freezing as they can keep the quality and availability of colostrum nutrients such as immunoglobulins and leukocytes. Future studies should focus on the feeding impact of stored colostrum and its nutrient composition especially immunoglobulins or other bioactive components to understand better what is the best preservation conditions for keeping colostrum nutrient composition in on-farm conditions