274 research outputs found
802-4 The Doppler Tei index during dobutamine stress echocardiography: A powerful predictor of mortality after acute myocardial infarction
Prevalence and prognostic implications of non-sustained ventricular tachycardia in ST-segment elevation myocardial infarction after revascularization with either fibrinolysis or primary angioplasty
Automatic QRS complex detection algorithm designed for a novel wearable, wireless electrocardiogram recording device
Mortality Risk Among Heart Failure Patients With Depression:A Nationwide Population-Based Cohort Study
BACKGROUND: The prevalence of depression is 4â to 5âfold higher in heart failure patients than in the general population. We examined the influence of depression on allâcause mortality in patients with heart failure. METHODS AND RESULTS: Using Danish medical registries, this nationwide populationâbased cohort study included all patients with a firstâtime hospitalization for heart failure (1995â2014). Allâcause mortality risks and 19âyear mortality rate ratios were estimated based on Cox regression analysis, adjusting for age, sex, time period, comorbidity, and socioeconomic status. The analysis included 9636 patients with and 194 887 patients without a diagnosis of depression. Compared with patients without a history of depression, those with depression had higher 1âyear (36% versus 33%) and 5âyear (68% versus 63%) mortality risks. Overall, the adjusted mortality rate ratio was 1.03 (95% CI 1.01â1.06). Compared with no depression, the adjusted mortality rate ratios for mild, moderate, and severe depression, as defined by diagnostic codes, were 1.06 (95% CI 1.00â1.13), 1.03 (95% CI 0.99â1.08), and 1.02 (95% CI 0.96â1.09), respectively. In a subcohort of patients, the mortality rate ratios were modified by left ventricular ejection fraction, with adjusted mortality rate ratios of 1.17 (95% CI, 1.05â1.31) for â¤35%, 0.98 (95% CI 0.81â1.18) for 36% to 49%, and 0.96 (95% CI 0.74â1.25) for âĽ50%. Results were consistent after adjustment for alcohol abuse and smoking. CONCLUSIONS: A history of depression was an adverse prognostic factor for allâcause mortality in heart failure patients with left ventricular ejection fraction â¤35% but not for other heart failure patients
Trends in quality of care among patients with incident heart failure in Denmark 2003-2010:a nationwide cohort study
LEFT ATRIAL SIZE AND FUNCTION AS PREDICTOR FOR NEW-ONSET OF ATRIAL FIBRILLATION IN PATIENTS WITH ASYMPTOMATIC AORTIC STENOSIS. THE SIMVASTATIN IN AORTIC STENOSIS STUDY
Galectin-3 and fibulin-1 in systolic heart failure:relation to glucose metabolism and left ventricular contractile reserve
Abstract
Background
Heart failure (HF) patients with diabetes (DM) have an adverse prognosis and reduced functional capacity, which could be associated with cardiac fibrosis, increased chamber stiffness and reduced left ventricular (LV) contractile reserve. Galectin-3 (Gal-3) and fibulin-1 are circulating biomarkers potentially reflecting cardiac fibrosis. We hypothesize that plasma levels of Gal-3 and fibulin-1 are elevated in HF patients with DM and are associated with reduced LV contractile reserve in these patients.
Methods
A total of 155 patients with HF with reduced ejection fraction underwent a low-dose dobutamine echocardiography and blood sampling for biomarker measurements. Patients were classified according to history of DM and an oral glucose tolerance test (OGTT) as: normal glucose tolerance (NGT) ( n \u2009=\u200970), impaired glucose tolerance (IGT) ( n \u2009=\u200925) and DM ( n \u2009=\u200960).
Results
Galectin-3 levels were elevated in DM patients as compared to non-diabetic patients ( P \u2009=\u20090.02), while higher fibulin-1 levels were observed in HF patients with IGF and DM ( P \u2009=\u20090.07). Reduced LV contractile reserve was associated with increasing Gal-3 levels (\u3b2\u2009=\u2009\u22120.19, P \u2009=\u20090.03) although, this association was attenuated after adjustment for estimated glomerular filtration rate ( P \u2009=\u20090.66). Fibulin-1 was not associated with LV contractile reserve ( P \u2009=\u20090.71).
Conclusions
Galectin-3 and fibulin-1 levels were elevated in HF patients with impaired glucose metabolism. However, reduced LV contractile reserve among HF patients with DM does not to have an independent impact on plasma Gal-3 and fibulin-1 levels
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