Soothing and anti-itch effect of quercetin phytosome in human subjects: A single-blind study

Background: We evaluated the ability of quercetin, a natural antioxidant formulated in a specific delivery system, to reduce skin inflammation induced by a variety of stimuli, including UV radiation, stimulation with a histamine solution, or contact with chemical irritants. In particular, we tested the soothing and anti-itch effect of Quercevita\uc2\uae, 1% cream for external use, a formulation characterized by a phospholipids-based delivery system. Patients and methods: The study was a monocentric, single blind trial that enrolled a group of 30 healthy volunteers. The back of each subject was examined to identify four quadrants with no previous skin damage or naevi that were treated in order to induce a controlled and reversible form of skin stress. The areas were treated as follows: no product; Quercevita\uc2\uae 1% cream, 2 mg/cm2; placebo; positive control (a commercially available topical formulation containing 1% dexchlorpheniramine). Results: Only quercetin phospholipids 1% and dexchlorpheniramine 1% achieved a significant reduction in erythema with comparable results: (\ue2\u80\u9310.05% [P=0.00329] for quercetin phospholipids 1% vs \ue2\u80\u9314.05% [P=0.00046] for the positive control). Moreover, quercetin phospholipids 1% and dexchlorpheniramine 1% were both associated with a significant decrease in mean wheal diameter: (\ue2\u80\u9313.25% and \ue2\u80\u9312.23% for dexchlorpheniramine 1%, respectively). Similar findings were reported for the other tested parameters. Conclusion: Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function, increasing hydration, and reducing water loss

Transarterial radioembolization for hepatocellular carcinoma: a review

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is the second cause of death due to malignancy in the world. The treatment of HCC is complex and includes potentially curative and palliative approaches. However, both curative and palliative treatments for HCC are often associated with a not-completely favorable safety/efficacy ratio. Therefore, other treatment options appear necessary in clinical practice. Transarterial radioembolization has shown a promising efficacy in terms of disease control and is associated with a good safety profile. This review discusses the use of transarterial radioembolization in HCC, with a focus on the clinical aspects of this therapeutic strategy

Study of dendritic avalanches by current noise measurements in High Tc Superconductors

Spectral noise power measurements are reported in a bulk YBa(2)Cu(3)O(7-delta) superconductor at 4.2 K to investigate the flux vortex avalanche processes originated from thermomagnetic instabilitites in an applied magnetic field up to 600 mT and in feeding current close to the critical value. 1/f(gamma) behavior is shown at frequencies below 10 Hz, gamma values range from 0.7 to 1.7. A sharp peak is observed in applied field and from these results we have obtained a cutoff frequency around 20 Hz for Lorentzian shape knee from which we estimate a mean number of 500 vortices and a mean velocity of about 20 cm/s for the average avalanche

Glutathione in the treatment of liver diseases: insights from clinical practice

Liver diseases markedly contribute to the global burden of mortality and morbidity. The pathogenesis of alcohol- and non-alcohol-induced liver diseases is complex, and many factors have been described to contribute to the progressive loss of liver functions, including the over-generation of reactive oxygen species. Glutathione (GSH) is the most important low-molecular-weight antioxidant synthesized in cells, as it is a reducing molecule which can react to oxygen species by neutralizing the unpaired electrons that make them highly reactive and dangerous. ROS over-production impairs the intracellular GSH homeostasis, leading to GSH deficiency, a pathophysiological hallmark in alcoholic and non-alcoholic liver diseases.Judging on the basis of the evidence obtained from experimental research and previous clinical studies, GSH administration seems to be a promising strategy to recover oxidative stress-induced liver damages in alcoholic and non-alcoholic liver diseases

Crackling noise peaks as signature of avalanche correlation

Until now, all existing theories failed to explain peaks in the power noise spectra. Here we focus on the role of correlation among avalanches as the main source of the noise peaks observed. The present theory is based on first principles statistics of elementary events clustered in time-amplitude correlated avalanches. A noise spectral power master equation suitable to explain any peaked noise spectra is analytically achieved. Excellent agreement with our noise experiments in superconductors and with recent experiments in Escherichia coli, in single DNA molecule, and in single electron tunneling is reporte

ELECTRICAL AND MAGNETIC-PROPERTIES OF THE PSEUDOBINARY SYSTEM (U1-XTHX)14AU51

A new family of the noble metal-actinide intermetallics was investigated. The electrical resistivity and magnetic susceptibility measurements on some pseudobinary phases in the U14Au51\ue5f8Th14Au51 system are reported. The effects of the observed competition between strong antiferromagnetic coupling and itinerant. Kondo-like 5f states are discussed

EVIDENCE OF STRONG CORRELATIONS BETWEEN ANOMALOUS LATTICE-PARAMETERS AND TRANSPORT-PROPERTIES IN CE16RU9

The new phase View the MathML source) was examined via the temperature dependences of the lattice parameters (10\u2013300 K), magnetic susceptibility (1.5\u2013300 K) and electrical resistivity (0.3\u2013300 K). Different Ce valences (+4 and +3) for different crystallographic sites are proposed from magnetic data and are supported by previous structural results. No magnetic order is observed down to 0.3 K. Highly anisotropic stresses observed in the electrical resistivity temperature dependence are attributed to the anomalous thermal behaviour of the lattice parameter c

Investigations about the chemical pressure effects on the valence behaviour of Praseodymium intermetallics. I: The Pr1-xYxSn3 family

The pseudo-binary Pr1 12xYxSn3 system was investigated to detect possible valence instabilities of praseodymium induced by chemical pressure. Differential thermal analysis, metallographic and X-ray determinations showed that the solid solubility of yttrium in the cubic PrSn3 lattice occurs in a narrow homogeneity range of yttrium concentration (0\u20130.3 atoms per formula unit). Magnetic susceptibility measurements were performed in the temperature range 1.5\u2013300 K for the existing phases. Evidence of chemical pressure effects is shown, but antiferromagnetic order persists in all the phases examined. Deviations from the molecular field approximation are observed

Primary Stability Study in Implantology: Correlation of Micromovements to Bone Density and Peak Insertion Torque

In modern implantology, one of the relevant issues regards the assessment of the primary stability. In particular, the role played by micromevements and their effects on various factors such as the intertional torque and bone density are of highest interest. A detailed knowledge of interconnections would be of great clinical relevance in suggesting a more rational application of the immediate loading thus reducing the failure rate. However, the study of the correlations of insertional torque and cortical and cancellous bone densities led to controversial results concerning micromovements and finally the primary stability. We propose here a more focused study on direct evaluations of micromovements