La vida no basta

Técnica: Mixta/CollageMateria-soporte: Lienzo/Mader

Talking Pupils : the Arrue Proyect 2011 : research, results and contributions of experts

Este libro presenta los resultados del Proyecto Arrue 2011 y los enriquece con 23 artículos de expertos que analizan sus conclusiones. El Proyecto Arrue es un programa de investigación creado por el Clouster de Sociolingüística y aplicado al uso de la lengua vasca en la escuela.This book presents the results of the Arrue Project 2011 and 23 contributions covering experts’ views on and analyses of this research. The Arrue Project is a research programme on lenguage use by pupils in school, created by Soziolinguistika Klusterra.ES

Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.

The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o proteins in the medial prefrontal cortex (mPCx) of the obese Zucker rats. The CB1 receptor density was higher in the prelimbic (PL) and infralimbic (IL) subregions of the mPCx of obese Zucker rats relative to their lean littermates which was associated with a higher percentage of CB1 receptor immunopositive excitatory presynaptic terminals in PL and IL. Also, a higher expression of CB1 receptors and WIN55,212-2-stimulated [35S]GTPγS binding was observed in the mPCx but not in the neocortex (NCx) and hippocampus of obese rats. Low-frequency stimulation in layers II/III of the mPCx induced CB1 receptor-dependent long-term synaptic plasticity in IL of area obese Zucker but not lean rats. Overall, the elevated 2-AG levels, up-regulation of CB1 receptors, and increased agonist-stimulated [35S]GTPγS binding strongly suggest that hyperactivity of the endocannabinoid signaling takes place at the glutamatergic terminals of the mPCx in the obese Zucker rat. These findings could endorse the importance of the CB1 receptors located in the mPCx in the development of obesity in Zucker rats.This work was supported by grants of the Basque Government (grants numbers IT1230-19 and IT1620-22 to PG), the Spanish Government (grant numbers CTQ2017-85686-R to MG and JS) and the Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript