The "Palliative Care Quality of Life Instrument (PQLI)" in terminal cancer patients

BACKGROUND: This paper describes the development of a new quality of life instrument in advanced cancer patients receiving palliative care. METHODS: The Palliative Care Quality of Life Instrument incorporates six multi-item and one single-item scale. The questionnaire was completed at baseline and one-week after. The final sample consisted of 120 patients. RESULTS: The average time required to complete the questionnaire, in both time points, was approximately 8 minutes. All multi-item scales met the minimal standards for reliability (Cronbach's alpha coefficient ≥.70) either before or during palliative treatment. Test-retest reliability in terms of Spearman-rho coefficient was also satisfactory (p < 0.05). Validity was demonstrated by inter-item correlations, comparisons with ECOG performance status, factor analysis, criterion-related validation, and correlations with the Assessment of Quality of Life in Palliative Care Instrument (AQEL), and the European Organisation for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30, version 3.0). CONCLUSION: The PQLI is a reliable and valid measure for the assessment of quality of life in patients with advanced stage cancer

Psychometric properties of the impact of event scale in Greek cancer patients

To develop the Greek version of the Impact of E vent Scale-Revised (IES-R-Gr), assess its Psychometric properties, and finally to examine the impact of cancer diagnosis to a palliative care patient sample, the IES-R was translated into Greek using the “forward-backward” procedure. It was administered twice, at one-week intervals, to 82 eligible patients with advanced cancer. Together with the IES-R-Gr scale, the patients also completed the Hospital Anxiety and Depression (HAD) Scale. Reliability was assessed in terms of internal consistency (Cronbach’s alpha coefficients) and test/retest (Spearman’s r value and Kendall’s tau-b). Construct validity was demonstrated through association with the HAD Scale, and convergence and discriminative validity and interscale correlations were also assessed. The Greek version of the IES-R had Cronbach’s alphas for the intrusion, avoidance, and hyperarousal scales of 0.72, 0.77, and 0.85, respectively. Overall test-retest reliability was satisfactory at P &lt; 0.0005. Satisfactory construct validity was supported by the correlation analysis between the IES-R-Gr subscales and anxiety and depression. Factor analysis yielded three factors, explaining 57.26% of the variance. Interscale and interitem correlations were found satisfactory at P &lt; 0.0005. These results demonstrate that the IES-R-Gr is an instrument with satisfactory psychometric properties and is a valid research tool for the impact of cancer diagnosis in advanced cancer patients

The families evaluation on management, care and disclosure for terminal stage cancer patients

Abstract Background Quality of life is an important concept which is subjective and personal; what is an acceptable quality of life to one may be 'worse than death' to another. The objective of this study was to develop and validate a questionnaire to assess relatives' perceptions and attitudes towards their terminal stage cancer patients' management (information disclosure, treatment choice, hospitalization and support-communication and care) including aspects regarding end-of-life and quality-of-life decisions. Methods The final study consisted of 146 relatives of advanced terminal stage cancer patients receiving palliation, attending a Pain Relief and Palliative Care Unit. The questionnaire incorporated 6 multi-item and 7 single-item scales, and was developed following a systematic review of measures appropriate for use in palliative care settings. Results Following analysis of the 25-item scale, the questionnaire has been validated as a shortened 21-item scale consisting of 5 multi-item and 5 single-item scales. Factor analysis was based upon information disclosure, hospitalization, and support-communication demonstrating Cronbach's alpha coefficients of 0.66, 0.5 and 0.70 respectively. Average item totals and inter-item scale correlations were between 0.62–0.70, with convergent validity correlations between 0.60–0.86. The questionnaire was well accepted by all subjects with an 8–10 minute completion time. Conclusion The shortened 21-item self-assessment questionnaire may provide acceptable and valid assessment of caregiver(s)/Greek cancer patients' relatives perceptions on palliative care.</p

Psychological distress of patients with advanced cancer - Influence and contribution of pain severity and pain interference

The growing interest in the psychological distress and the multidimensionality of pain in patients with cancer has been the major reason for the conduction of this study. The aims we; re to evaluate psychological distress and pain in patients with advanced cancer and the impact of pain severity and pain interference dimensions on the anxiety and depression. One hundred twenty patients with advanced cancer were surveyed at a palliative care unit in Athens, Greece. Greek versions of the Hospital Anxiety and Depression (G-HAD) scale and the Brief Pain Inventory were administered. Information concerning patients’ treatment received was acquired from the medical records, whereas physicians recorded their clinical condition. The analysis showed that significant associations were found between pain interference to “mood” and HAD-A (anxiety) (r = 0.252, P =.005) and between pain interference to “relations with other people” and HAD-A (r = 0.474, P &lt;.0005). Multiple regression analyses showed that “average pain” (P &lt;.05), pain interference’to “walking ability” (P &lt;.05), “normal work” (P &lt;.05, and “relations with other people” are significant predictors of HAD-anxiety (HAD-A) (P &lt;.0005), explaining 46.2% of total variance. For depression (HAD-D), the Greek version of the Brief Pain Inventory dimension that serve as predictor is “enjoyment of life,” as well as the demographic variables of “age,” and “gender” (P &lt;.05), explaining 22.2% of variance. Moreover, a further analysis of the pain severity and pain interference scales showed that they differentiate the anxiety of the patients with cancer. In this patient sample, pain interference and, to a lesser extent, pain severity was significantly associated with psychological distress (anxiety and pain), whereas pain interference to “walking ability,” “normal work,” and “relations with other people” was found to be more prominent and troublesome to patients’ anxiety than that to patients’ depression

Personal growth and psychological distress in advanced breast cancer

Aims: the experience of posttraumatic growth following breast cancer, its association with psychological distress and the predictive value of psychological distress, sociodemographic and clinical characteristics of cancer patients in their personal growth. Methods: The Posttraumatic Growth Inventory and the Greek version of the Hospital Depression and Anxiety Scale (G-HADS) were administered to 100 breast cancer patients. Sociodemographic and clinical characteristics were recorded. Results: The analysis showed that significant associations were found between PTGI-Total patients’ age (p = 0.001), and being married (p = 0.007). Moreover, significant associations was observed between PTGI-II (”New Possibilities”) and HADS-Depression (r = -0.314, p &lt; 0.05). Multiple regression analyses showed that age is a significant predictor of PTGI-II (”New Possibilites”) (p = 0.005), PTGI-V (”Apreciation of Life”) (p = 0.0005) and PTGI-Total (p = 0.037), while marital status is a significant predictor of PTGI-Total (p = 0.009). Conclusion: Specific patients’ characteristics, such as young age and being with a partner with a partner, influence the experience of posttraumatic growth in breast cancer patients. (c) 2008 Elsevier Ltd. All rights reserved

Oral versus intravenous ibandronic acid: a comparison of treatment options for metastatic bone disease

Purpose This trial is the first to compare directly the clinical response to and safety of oral and intravenous (IV) ibandronic acid for metastatic bone disease. Methods Patients &gt;= 18 years with breast, prostate, lung, urogenital or colon cancer received IV ibandronic acid 6 mg infused over 15 min every 28 days or oral ibandronic acid 50 mg/day. Clinical response was determined using bone scintigraphy, radiography and serum C-terminal telopeptide of type I collagen (S-CTX) at months 3-6. Adverse events and biochemical safety measures were recorded. Results A total of 84.6 and 88.5% of patients had a complete/partial response to IV and oral ibandronic acid, respectively. Median percentage decreases in S-CTX were -39 and -35%, respectively. Bone pain scores decreased and analgesic use increased from month 0-3 and were stable from months 3-6. Both formulations improved physical and functioning scores. Conclusion Oral and IV ibandronic acid for bone metastases have similar efficacy and tolerability

Psychometric properties of the brief fatigue inventory in Greek patients with advanced cancer

To validate the Greek version of the Brief Fatigue Inventory (BFI-Gr) in a sample of cancer patients, the scale was translated with the “forward-backward” procedure to Greek. It. was administered twice, at a three-day interval, to 102 eligible patients with cancer. Together with the BFI-Gr scale, the patients also completed the European Organization for Research and Treatment of Cancer QLQ-C30 (version 3.0) subscales of faligue and emotional functioning, and the M. D. Anderson Symptom Inventory. The BFI-Gr had an overall Cronbach alpha for the nine items of 0.954. The assessment of the relationships between the BFI-Gr and the other measurements showed statistically significant correlations between all the assessed measurements (r values between 0.47 and 0.76, P &lt; 0.0005), except with the emotional subscale of the European Organization for Research and Treatment of Cancer scale. Factor analysis yielded a one-factor solution, explaining 73.6% of the variance. Interitem correlations were high and ranged from 0.567 to 0.882 (P &lt; 0.0005). The test-retest reliability of scale showed that, the coefficient agreement was 0.901 (P &lt; 0.0005). Univariate analysis revealed significant correlations between hemoglobin and fatigue (r = -0.21, P = 0.037), and between performance status (P &lt; 0.0005) and opioids (P = 0.009). These results support that the BFI-Gr is an instrument with satisfactory psychometric properties, and is a valid research tool for cancer-related fatigue in Greek cancer patients