Reporäntans påverkan på svenska branschindex

Examensarbetets titel: Reporäntans påverkan på svenska branschindex Seminariedatum: 2015-01-15 Ämne/kurs: FEKH89 Examensarbete i finansiering på kandidatnivå, 15 HP Författare: Richard Eek, Martin Klarin, Christofer Karlsson Handledare: Erling Green Fem nyckelord: Reporänta, onormal avkastning, händelsestudie, branschindex, ränteförändring. Syfte: Syftet med den här uppsatsen är att utreda marknadseffektiviteten samt vilken inverkan en justering av reporäntan har på olika branschindex på den svenska aktiemarknaden. Metod: Vi har genomfört en kvantitativ studie och genom en händelsestudie undersökt den onormala avkastningen för 8 olika branschindex på Nasdaq Stockholm. Teoretiska perspektiv: Uppsatsen utgår från tidigare forskning om hur en ränteförändring påverkar aktiemarknaden. Vi har utgått från studier som har gjorts på den svenska och amerikanska aktiemarknaden. Empiri: Vi har valt ut 8 olika branschindex på Nasdaq Stockholm. De indexen vi har valt ger ett bra urval av olika delar av aktiemarknaden. Indexen är Oil & gas, Basic materials, Industrials, Consumer goods, Consumer service, Health care, Technology och Financials. Resultat: Våra resultat visar att marknaden är inte är effektiv. Marknaden prisar inte in en ränteförändring direkt, utan det finns tecken både på att det sker en fördröjd reaktion från marknaden och att marknaden prisar in ränteförändringen redan innan den har skett. Vi har även sett att det förekommer skillnader i den kumulativa avkastningen mellan olika branschindex

Multi-Modal SLAM for Accurate Localisation in Self-similar Environments

Regular inspection and maintenance (I&M) of road tunnels is critical for ensuring safe operation and maximising the infrastructure's longevity. Today's I&M operations are time-consuming and disruptive to normal operations, but advances within robotics, automation, and digitalisation promise significant productivity gains. Accurate and reliable localisation is key to achieving this, but poses significant challenges in tunnels due to the absence of GNSS signals and the self-similar nature of the environment. This paper presents a novel approach for achieving real-time high-accuracy localisation in tunnels such that it can be used for autonomous navigation. The proposed system implements a simultaneous localisation and mapping (SLAM) solution that integrates data from scanning LiDAR, camera and inertial measurement unit (IMU). We have developed a novel approach that fuses the information from these sensors at the feature level and jointly optimises over all constraints. This enables our system to overcome the degeneracy of typical SLAM solutions in self-similar environments such as tunnels. To evaluate the performance of the proposed system, experiments and autonomous missions were conducted in real tunnels, and comparisons were made against existing localisation methods. The results demonstrate that the proposed system achieves high accuracy and exhibits good robustness in challenging tunnel conditions.acceptedVersio

Durable response with single-agent acalabrutinib in patients with relapsed or refractory mantle cell lymphoma

Bruton tyrosine kinase (BTK) inhibitors have greatly improved the spectrum of treatment options in mantle cell lymphoma (MCL) [1–4]. Acalabrutinib is a highly selective, orally administered, and potent BTK inhibitor with limited off-target activity [5]. Acalabrutinib was approved in 2017 by the US Food and Drug Administration for the treatment of relapsed/refractory MCL based on clinical data from the open-label, multicenter, phase 2 ACE-LY-004 study of acalabrutinib 100 mg twice daily [1]. Here, we present updated results from the ACE-LY-004 study after a median 26-month follow-up. Eligibility criteria and study design were published previously (Supplementary methods) [1]. Analysis of minimal residual disease (MRD) was conducted after complete response (CR) or partial response (PR) was achieved using the quantitative ClonoSEQ next-generation sequencing (5 × 10−6 ) assay (Adpative Biotechnologies, Seattle, WA, USA) in consenting patients with available paired archival tumor and whole blood samples. Data are updated as of February 12, 2018

Carfilzomib, thalidomide, and dexamethasone is safe and effective in relapsed and/or refractory multiple myeloma: final report of the single arm, multicenter phase II ALLG MM018/AMN002 study.

This multicentre, phase II study of the Australian Lymphoma and Leukaemia Group (ALLG) and the Asian Myeloma Network (AMN) investigated fixed-duration (18-month) treatment with carfilzomib (K), thalidomide (T), and dexamethasone (d; KTd) in patients with relapsed and/or refractory multiple myeloma and 1-3 prior lines of therapy. Patients received induction with up to twelve 28-day cycles of K [20mg/m2 IV cycle 1 day 1 and 2, 56mg/m2 (36mg/m2 for patients ≥75 years) from day 8 onwards), T 100mg PO nocte and weekly dexamethasone 40mg (20mg for patients ≥75 years). During maintenance T was omitted, while K continued on days 1,2,15,16 with fortnightly dexamethasone. The primary endpoint was progression free survival (PFS). Secondary endpoints were overall response rate, overall survival (OS), duration of response, safety, and tolerability. Ninety-three patients (median age 66.3 years (41.9 – 84.5)) were enrolled with a median follow-up of 26.4 (1.6 – 54.6) months. The median PFS was 22.3 months (95% CI 15.7 – 25.6) with a 46.3% (95% CI 35.1 – 52.8) 2-year PFS. Median OS was not reached and was 73.8% (95% CI 62.9 – 81.9) at 2 years. The overall response rate was 88% (≥ VGPR 73%). There was no difference in the depth of response, PFS or OS comparing Asian and Non-Asian cohorts (p=0.61). The safety profile for KTd was consistent with each individual drug. KTd is well tolerated and effective in patients with RRMM irrespective of Asian or non-Asian ethnicity and provides an alternative option particularly where use of KRd is limited by access, cost, or renal impairment

Test beam results of a stereo preshower integrated in the liquid argon accordion calorimeter

This paper describes the construction of an integrated preshower within the RD3 liquid argon accordion calorimeter. It has a stereo view which enables the measurement of two transverse coordinates. The prototype was tested at CERN with electrons, photons and muons to validate its capability to work at LHC ( Energy resolution, impact point resolution, angular resolution, $\pi^o$/$\gamma$ rejection )

Limits on the production of scalar leptoquarks from Z (0) decays at LEP

A search has been made for pairs and for single production of scalar leptoquarks of the first and second generations using a data sample of 392000 Z0 decays from the DELPHI detector at LEP 1. No signal was found and limits on the leptoquark mass, production cross section and branching ratio were set. A mass limit at 95% confidence level of 45.5 GeV/c2 was obtained for leptoquark pair production. The search for the production of a single leptoquark probed the mass region above this limit and its results exclude first and second generation leptoquarks D0 with masses below 65 GeV/c2 and 73 GeV/c2 respectively, at 95% confidence level, assuming that the D0lq Yukawa coupling alpha(lambda) is equal to the electromagnetic one. An upper limit is also given on the coupling alpha(lambda) as a function of the leptoquark mass m(D0)