Pamela Toliver Interview for the Veterans\u27 Voices Project

Pamela A. Toliver (DOB: January 30, 1954) enlisted in the United States Air Force in 1980. She served during both Operation Desert Shield and Operation Desert Storm. Toliver received the Air Force Commendation Medal. She was discharged with the rank of E-6 in 1994.https://corescholar.libraries.wright.edu/veterans_voices/1084/thumbnail.jp

Robert Maxwell Interview for the Veterans\u27 Voices Project

Robert Maxwell (DOB: May 29, 1991) enlisted in the United States Air Force in July of 2010. He served at Minot Air Force Base in North Dakota in the 705th Munitions Squadron. He left military service with the rank of E-4 in July 2016 to pursue a college degree in Computer Engineering.https://corescholar.libraries.wright.edu/veterans_voices/1128/thumbnail.jp

Derek Pridemore Interview for the Veterans\u27 Voices Project

Derek Pridemore (DOB: January 11, 1983) enlisted in the United States Navy in 2001 and graduated from boot camp two days after 9/11. He was stationed at Norfolk, VA, NSA Bahrain, and the USS Theodore Roosevelt. He served during Operation Enduring Freedom and Operation Iraqi Freedom. Pridemore was Supply Officer and achieved the rank of E4 when he was discharged in 2005.https://corescholar.libraries.wright.edu/veterans_voices/1108/thumbnail.jp

Keturah Edwards Interview for Veterans\u27 Voices Project

Keturah Elaine Natividad Edwards (DOB: September 26, 1986) enlisted in the United States Navy in February 2010. She served aboard the USS Iwo Jima (LHD-7) and the USS Boxer (LHD-4). Ms. Edwards left the Navy in August 2015.https://corescholar.libraries.wright.edu/veterans_voices/1151/thumbnail.jp

Allen C. Riley Interview for the Veterans\u27 Voices Project

Allen C. Riley (DOB: July 18, 1942) enlisted in the United States Navy in October of 1961. He served during the Vietnam War on board the USS Mispillion and the YR-71 in the South China Sea. He left the Navy in July of 1967 having achieved the rank of BM3.https://corescholar.libraries.wright.edu/veterans_voices/1125/thumbnail.jp

Curtis Kane Interview for the Veterans\u27 Voices Project

Curtis Kane (DOB: May 1, 1966) enlisted in the United States Navy in 1983. He attended Airman Apprenticeship School in San Diego, CA. He was stationed on the aircraft carrier USS America in the Hanger Bay Division working as an aircraft handler and firefighter. He was also on the USS Nassau working the flight deck. He left the service in 1989, became a civilian firefighter, and joined the Army National Guard followed by the Navy National Guard. Curtis served during the 1986 Libyan Operations, Operation Enduring Freedom, and Operation Iraqi Freedom.https://corescholar.libraries.wright.edu/veterans_voices/1097/thumbnail.jp

Caspofungin Inhibits Rhizopus oryzae 1,3-β-d-Glucan Synthase, Lowers Burden in Brain Measured by Quantitative PCR, and Improves Survival at a Low but Not a High Dose during Murine Disseminated Zygomycosis

Rhizopus oryzae is the most common cause of zygomycosis, a life-threatening infection that usually occurs in patients with diabetic ketoacidosis. Despite standard therapy, the overall rate of mortality from zygomycosis remains >50%, and new strategies for treatment are urgently needed. The activities of caspofungin acetate (CAS) and other echinocandins (antifungal inhibitors of the synthesis of 1,3-β-d-glucan synthase [GS]) against the agents of zygomycosis have remained relatively unexplored, especially in animal models of infection. We found that R. oryzae has both an FKS gene, which in other fungi encodes a subunit of the GS synthesis complex, and CAS-susceptible, membrane-associated GS activity. Low-dose but not high-dose CAS improved the survival of mice with diabetic ketoacidosis infected with a small inoculum but not a large inoculum of R. oryzae. Fungal burden, assessed by a novel quantitative PCR assay, correlated with increasing inocula and progression of disease, particularly later in the infection, when CFU counts did not. CAS decreased the brain burden of R. oryzae when it was given prophylactically but not when therapy was started after infection. These results indicate that CAS has significant but limited activity against R. oryzae in vivo and demonstrates an inverse dose-response effect. The potential for CAS to play a role in combination therapy against zygomycosis merits further investigation