39 research outputs found
Ambiente virtual de aprendizagem na educação continuada em enfermagem
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
The Rotterdam Study: 2016 objectives and design update
- Author
- A Alonso
- A Ciorba
- A Dehghan
- A Dehghan
- A Dehghan
- A Etemadi
- A Ganna
- A Hofman
- A Hofman
- A Hofman
- A Hofman
- A Holtermann
- A Hruby
- A Icks
- A Ilar
- A Kottgen
- A Kyrozis
- A Luczynska
- A Lundby
- A Martinsson
- A Ott
- A Ott
- A Pfeufer
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- A Ruitenberg
- A Ruitenberg
- A Sajjad
- A Sjolander
- A Stang
- A Stang
- A Stang
- A Vitezova
- A Vitezova
- A Westerlund
- AE Hak
- AE Odink
- AE Odink
- AI Iglesias
- AI Luik
- AI Luik
- AL Feldman
- Albert Hofman
- AM Valdes
- André G. Uitterlinden
- André Goedegebure
- AS Agatston
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- B Binachon
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- B Hamidou
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- B Schottker
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- B Yu
- BA in t’ Veld
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- BF Verhaaren
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- BP Krijthe
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- BP Krijthe
- BP Krijthe
- Bruno H. Ch. Stricker
- BS Ferket
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- C Bamia
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- CE Lovelock
- CJ Caspersen
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- D Aune
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- F Bloch
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- G Behrens
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- H Jacqmin-Gadda
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- Henning W. Tiemeier
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- I Kardys
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- K Aleksandrova
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- N Aarts
- N Aarts
- N Direk
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- N MacIntyre
- N Takaya
- NJ Wald
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- North American Symptomatic Carotid Endarterectomy Trial
- NS Weiss
- O Nevalainen
- O Nyren
- Oscar H. Franco
- P Boffetta
- P Gnagnarella
- P Jha
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- P Trouillas
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- RG Wieberdink
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- SE Elias-Smale
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- TA Hoeven
- TA Hoeven
- Tamar E. C. Nijsten
- TJ VanderWeele
- TJ VanderWeele
- U Mons
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- V Hjellvik
- V Ivkovic
- V Weyer
- VJ Verhoeven
- VJ Verlinden
- VJ Verlinden
- VJM Verhoeven
- VS Stel
- VT Baltar
- W Altorf-van der Kuil
- W Altorf-van der Kuil
- WB Grant
- WD Killgore
- WJ Jiang
- X Song
- XY Dai
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- YY Hoogendam
- ZZ Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Limited dispersal and its effect on population structure in the milkweed beetle Tetraopes tetraophthalmus
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ethische Empfehlungen zur Anwendung vonHerz-Lungen-Wiederbelebungsmaßnahmen: Ein Blick über die Grenzen — Beispiele aus Europa und den USA
- Author
- AL Kellermann
- American College of Emergency Physicians
- American College of Emergency Physicians
- American College of Emergency Physicians
- American Heart Association
- E Edgren
- Ethics Committee Society for Academic Emergency Medicine
- EV Boisaubin
- JE Ruark
- JG Adams
- JO Margolis
- KJ Schwenzer
- M Eliastam
- PE Pepe
- PJF Baskett
- S Dull
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1997
- Field of study
Review Paper: Origin and Molecular Pathology of Adrenocortical Neoplasms
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- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Tumores da córtex da supra-renal: o uso do p53 na diferenciação entre carcinomas e adenomas
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2000
- Field of study
Danish translation, cultural adaption and initial psychometric evaluation of the patient feedback form
- Author
- Ann-Dorthe Zwisler
- C Baeksted
- CF Snyder
- CF Snyder
- D Howell
- D Howell
- DA Dillman
- DL Streiner
- E Basch
- E Edgren
- E Shirley
- G Kotronoulas
- Graziella Zangger
- Helle Pappot
- J Greenhalgh
- J Greenhalgh
- JG Ponterotto
- JM Valderas
- K McGrail
- Karin B. Dieperink
- Lars Bastholt
- LB Mokkink
- Lærke K. Tolstrup
- M Wild Diana
- S Marshall
- SM Fox-Wasylyshyn
- VD Sousa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antígeno nuclear de proliferação celular em tumores de adrenal
- Author
- Adauto J. Cologna
- Antonio C. P. Martins
- Bertagna C
- Copeland PM
- Copeland PM
- Edgren M
- Goldblum JR
- Gruhn JG
- Hattoni K
- Haylton J. Suaid
- Henley DJ
- Hough AJ
- Hsu SN
- Klein FA
- Kobaiashi S
- Luciano N. Serafini
- Maria Angeles L. Velludo
- Medeiros LJ
- Morisak Y
- Nakano S
- Oyama T
- Prinz RA
- Richie JP
- Rodrigo A.R. Falconi
- Sanches Y
- Silvio Tucci Jr S
- Susuki T
- Taylor CR
- Van Slooten H
- Vargas MP
- Weiss LM
- Wiethege T
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2000
- Field of study
Music as a Tool in the Development of Nineteenth-Century Neurology
- Author
- A Graziano
- A Harrington
- A Knoblauch
- A Kussmaul
- A Macdonald
- A Proust
- A Trousseau
- AB Graziano
- AL Benton
- C Seashore
- D Brazier
- D Miliotti
- DC Finkelnburg
- F Moutier
- F Schiller
- H Oppenheim
- H Spencer
- HA Whitaker
- HA Whitaker
- HC Bastian
- J Falret
- J Johnson
- J Johnson
- J Johnson
- J Johnson
- J Parrot
- J-B Bouillaud
- JG Edgren
- JH Jackson
- M Lorch
- P Blocq
- P Broca
- P Broca
- P Broca
- P Eling
- R Wallaschek
- R Wallaschek
- RJ Duffy
- S Finger
- T Ribot
- W Riese
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study