Are brain metastases curable? Case report and a brief review of the literature

Background: Most of the times the prognosis of the patients with cancer who develop brain metastases remains incurable and hopeless with a median survival that goes between 2.7 and 15.07 month according to Grade Prognostic Assessment (GPA) Score for brain metastasis. Case summary: The following is a case report of a 33-year-old patient that presented with breast cancer and after one year of follow-up she developed one single brain metastases treated aggressively with surgery, whole brain radiotherapy (WBRT) 30 Gy in 10 Fractions and Stereotactic Radiosurgery (SRS) 22 Gy who achieved complete response and after more than 6 years since treatment the patient continues free of disease. Conclusion: An aggressive treatment for brain metastases in well-selected patients provides long periods of free intracranial disease, with acceptable results in the quality of life

Fractionated Stereotactic radiotherapy for POEMS syndrome: A case report

Background: POEMS syndrome is a rare neoplastic entity. It has population incidence of 0.3/100,000 and presents predominantly on the 5th or 6th decade of life. Its treatment is considered to be multidisciplinary. Case summary: We present the case of a 47 year old male patient with POEMS syndrome who was initially managed with chemotherapy but was treated with stereotactic radiation therapy for spinal cord compression associated due to a plasma cell neoplasm at the T6-T7 vertebral body. Conclusion: Radiation therapy is the preferred treatment modality for one to three isolated bone lesions, with a marked improvement in neuropathy