Integrating Statistical and Machine Learning Approaches to Identify Receptive Field Structure in Neural Populations

Neurons can code for multiple variables simultaneously and neuroscientists are often interested in classifying neurons based on their receptive field properties. Statistical models provide powerful tools for determining the factors influencing neural spiking activity and classifying individual neurons. However, as neural recording technologies have advanced to produce simultaneous spiking data from massive populations, classical statistical methods often lack the computational efficiency required to handle such data. Machine learning (ML) approaches are known for enabling efficient large scale data analyses; however, they typically require massive training sets with balanced data, along with accurate labels to fit well. Additionally, model assessment and interpretation are often more challenging for ML than for classical statistical methods. To address these challenges, we develop an integrated framework, combining statistical modeling and machine learning approaches to identify the coding properties of neurons from large populations. In order to demonstrate this framework, we apply these methods to data from a population of neurons recorded from rat hippocampus to characterize the distribution of spatial receptive fields in this region

Quantum Electrodynamics at Large Distances II: Nature of the Dominant Singularities

Accurate calculations of macroscopic and mesoscopic properties in quantum electrodynamics require careful treatment of infrared divergences: standard treatments introduce spurious large-distances effects. A method for computing these properties was developed in a companion paper. That method depends upon a result obtained here about the nature of the singularities that produce the dominant large-distance behaviour. If all particles in a quantum field theory have non-zero mass then the Landau-Nakanishi diagrams give strong conditions on the singularities of the scattering functions. These conditions are severely weakened in quantum electrodynamics by effects of points where photon momenta vanish. A new kind of Landau-Nakanishi diagram is developed here. It is geared specifically to the pole-decomposition functions that dominate the macroscopic behaviour in quantum electrodynamics, and leads to strong results for these functions at points where photon momenta vanish.Comment: 40 pages, 11 encapsulated postscript figures, latexed, math_macros.tex can be found on Archive. full postscript available from http://theorl.lbl.gov/www/theorgroup/papers/35972.p

Electron transfer driven decomposition of adenine and selected analogs as probed by experimental and theoretical methods

We report on a combined experimental and theoretical study of electron transfer induced decomposition of adenine and a selection of analogue molecules in collisions with potassium atoms (K). Time-of-flight negative ion mass spectra have been obtained in a wide collision energy range (6–68 eV in the centre-of-mass frame), providing a comprehensive investigation of the fragmentation patterns of purine, adenine, 9-methyl adenine, 6-dimethyl adenine and 2-D adenine. Following our recent communication about selective hydrogen loss from the transient negative ions (TNI) produced in these collisions [T. Dunha et al. J. Chem. Phys. 148, 021101 (2018)], this work focuses on the production of smaller fragment anions. In the low-energy part of the present range, several dissociation channels that are accessible in free electron attachment experiments are absent from the present mass spectra, notably NH2 loss from adenine and 9-methyl adenine. This can be understood in terms of a relatively long transit time of the K+ cation in the vicinity of the TNI tending to enhance the likelihood of intramolecular electron transfer. In this case, the excess energy can be redistributed through the available degrees of freedom inhibiting fragmentation pathways. Ab initio theoretical calculations were performed for 9-methyl adenine (9-mAd) and adenine (Ad) in the presence of a potassium atom and provided a strong basis for the assignment the lowest unoccupied molecular orbitals accessed in the collision process

Negotiation in strategy making teams : group support systems and the process of cognitive change

This paper reports on the use of a Group Support System (GSS) to explore at a micro level some of the processes manifested when a group is negotiating strategy-processes of social and psychological negotiation. It is based on data from a series of interventions with senior management teams of three operating companies comprising a multi-national organization, and with a joint meeting subsequently involving all of the previous participants. The meetings were concerned with negotiating a new strategy for the global organization. The research involved the analysis of detailed time series data logs that exist as a result of using a GSS that is a reflection of cognitive theory

Threshold behavior in metastable dissociation of multi-photon ionized thymine and uracil

Microsecond-timescale HNCO loss has been observed from single-color multi-photon ionized pyrimidine nucleobases in the gas phase. Photon energy thresholds for the metastable channels have been measured at 5.55 ± 0.02 eV for thymine and 5.57 ± 0.02 eV for uracil. We argue that these results can be attributed to accessing the molecules’ S1 states with additional vibrational energy matching the threshold energy for HNCO loss from the radical cation. Combined with previous photoionization energies, this enables the S1 adiabatic energies to be deduced: 3.67 ± 0.07 eV for thymine and 3.77 ± 0.07 eV for uracil. These values are consistent with recent calculations

A Cellular Automaton Model for Diffusive and Dissipative Systems

We study a cellular automaton model, which allows diffusion of energy (or equivalently any other physical quantities such as mass of a particular compound) at every lattice site after each timestep. Unit amount of energy is randomly added onto a site. Whenever the local energy content of a site reaches a fixed threshold $E_{c1}$, energy will be dissipated. Dissipation of energy propagates to the neighboring sites provided that the energy contents of those sites are greater than or equal to another fixed threshold $E_{c2} (\leq E_{c1})$. Under such dynamics, the system evolves into three different types of states depending on the values of $E_{c1}$ and $E_{c2}$ as reflected in their dissipation size distributions, namely: localized peaks, power laws, or exponential laws. This model is able to describe the behaviors of various physical systems including the statistics of burst sizes and burst rates in type-I X-ray bursters. Comparisons between our model and the famous forest-fire model (FFM) are made.Comment: in REVTEX 3.0. Figures available on request. Extensively revised. Accepted by Phys.Rev.

Flares and variability from Sagittarius A*: five nights of simultaneous multi-wavelength observations

Aims. We report on simultaneous observations and modeling of mid-infrared (MIR), near-infrared (NIR), and submillimeter (submm) emission of the source Sgr A* associated with the supermassive black hole at the center of our Galaxy. Our goal was to monitor the activity of Sgr A* at different wavelengths in order to constrain the emitting processes and gain insight into the nature of the close environment of Sgr A*. Methods. We used the MIR instrument VISIR in the BURST imaging mode, the adaptive optics assisted NIR camera NACO, and the sub-mm antenna APEX to monitor Sgr A* over several nights in July 2007. Results. The observations reveal remarkable variability in the NIR and sub-mm during the five nights of observation. No source was detected in the MIR, but we derived the lowest upper limit for a flare at 8.59 microns (22.4 mJy with A_8.59mu = 1.6+/- 0.5). This observational constraint makes us discard the observed NIR emission as coming from a thermal component emitting at sub-mm frequencies. Moreover, comparison of the sub-mm and NIR variability shows that the highest NIR fluxes (flares) are coincident with the lowest sub-mm levels of our five-night campaign involving three flares. We explain this behavior by a loss of electrons to the system and/or by a decrease in the magnetic field, as might conceivably occur in scenarios involving fast outflows and/or magnetic reconnection.Comment: 10 pages, 7 figures, published in A&

Is communication guidance mistaken? Qualitative study of parent-oncologist communication in childhood cancer

background: Guidance encourages oncologists to engage patients and relatives in discussing the emotions that accompany cancer diagnosis and treatment. We investigated the perspectives of parents of children with leukaemia on the role of paediatric oncologists in such discussion. methods: Qualitative study comprising 33 audio-recorded parent–oncologist consultations and semi-structured interviews with 67 parents during the year following diagnosis. results: Consultations soon after the diagnosis were largely devoid of overt discussion of parental emotion. Interviewed parents did not describe a need for such discussion. They spoke of being comforted by oncologists’ clinical focus, by the biomedical information they provided and by their calmness and constancy. When we explicitly asked parents 1 year later about the oncologists’ role in emotional support, they overwhelmingly told us that they did not want to discuss their feelings with oncologists. They wanted to preserve the oncologists’ focus on their child’s clinical care, deprecated anything that diverted from this and spoke of the value of boundaries in the parent–oncologist relationship. conclusion: Parents were usually comforted by oncologists, but this was not achieved in the way suggested by communication guidance. Communication guidance would benefit from an enhanced understanding of how emotional support is experienced by those who rely on it

Cognitive Information Processing

Contains reports on four research projects.National Aeronautics and Space Administration (Grant NsG-496)National Institutes of Health (Grant MH-04737-04)National Science Foundation (Grant GP-2495

Universal properties of superconformal OPEs for 1/2 BPS operators in 3≤D≤63\leq D \leq 6

We give a general analysis of OPEs of 1/2 BPS superfield operators for the $D=3,4,5,6$ superconformal algebras OSp(8/4,R), PSU(2,2), F${}_4$ and OSp($8^*/4$) which underlie maximal AdS supergravity in $4\leq D+1\leq 7$. \\ The corresponding three-point functions can be formally factorized in a way similar to the decomposition of a generic superconformal UIR into a product of supersingletons. This allows for a simple derivation of branching rules for primary superfields. The operators of protected conformal dimension which may appear in the OPE are classified and are shown to be either 1/2 or 1/4 BPS, or semishort. As an application, we discuss the "non-renormalization" of extremal $n$-point correlators.Comment: To be published in NJP Focus Issue: Supersymmetry in condensed matter and high energy physic