New Dyestuff Production to Sensitively Determine the Sealing Capacity of the Implant Abutment Connection

Aim: In this study, it was aimed to synthesize a new dyestuff with fluorescent active properties, which can be easily produced and water-soluble, to be used in sealing tests. Materials and Methods: The sealing capacities of the implant abutment connection of the dental implant systems manufactured by ESTAŞ were determined spectroscopically by UV-Vis spectrophotometer using the synthesized dyestuff in the first stage. Thanks to the fluorescent active property of the dyestuff, the emission spectra were measured with the fluorescent spectrometer, which is highly sensitive to changes, and the sealing capacities could be determined more precisely, depending on time. In addition, the gap between the implant and the abutment connection was determined using a Scanning Electron Microscope (SEM), and the sealing capacities were evaluated from a different perspective. In addition, sealing tests of the same implant systems were also performed with methylene blue dyestuff and the results were compared. The efficiency of our synthesized dyestuff was determined. Results: The dyestuff to be used in the sealing tests of the implants was synthesized and characterized in a short time in our laboratory. The phthalocyanine compound from the porphyrin class was obtained as a result of the tetramerization reaction of the synthesized phthalonitrile derivative. The dyestuff, which can be synthesized in a short time like 10 minutes, was purified by taking advantage of the solubility difference and chromatographic methods. The obtained dyestuff was characterized by NMR, FTIR, UV-Vis, and MALDI-TOF MS. The results obtained are in harmony with the structure of the molecule. The dyestuff produced is water soluble and was especially used to determine the sealing capacity of the implant abutment connection of dental implant systems produced by ESTAŞ. The sealing properties of the implant were determined by spectroscopic methods such as UV-Vis and fluorescence. In addition, sealing capacities were evaluated with SEM. According to the results obtained, we can say that the synthesized dyestuff is a dye that can give spectroscopically more sensitive results than methylene blue. Conclusions: Dental implants, which are artificially placed in the mouth to support dental prostheses, have changed dental treatment methods to a large extent and become the most preferred successful technique. However, infection risks may occur during the treatment due to the formation of a gap between the abutment cap and the implant resulting from both the production and adaptation of the abutment cap, which is a part of the implant. For this reason, it is important that the implants produced are routinely sensitively checked for sealing and put into use. In addition, sealing control will contribute to the control and shaping of the process from the manufacturing stage of the implant. In line with all the data obtained, it has been determined that the implant types produced by ESTAŞ have a sealing capacity below the acceptable limits. In addition, it was observed that our newly synthesized dyestuff spectroscopically gave sensitive results in the sealing tests of implant systems

Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines

Human hepatocellular carcinoma (HepG2) cells and colorectal adenocarcinoma (DLD-1) cells were treated with the synthesized water soluble phthalocyanine derivatives to understand the effect of the compounds both on colorectal and liver cancer cells. The compounds inhibited cell proliferation and displayed cytotoxic effect on these cancer cell lines however; the effect of the compounds on healthy control fibroblast cell line was comparatively lower. The compounds can be employed for cancer treatment as anticancer agents.</span