The Effects of Bone Mineral Density and Level of Serum Vitamin-D on Pain and Quality of Life in Fibromialgia Patients - Original Investigation

Aim: The purpose of this study is to determine bone mineral density (BMD) and the levels of serum 25-OH-vitamin D3 in premenopausal Fibromyalgia Syndrome (FMS) patients, and to examine the effect of them to the pain and quality of life in premenopausal FMS patients. Material and Methods: Premenouposal 30 patients with fibromyalgia and 30 healthy controls included the study. The demographic characteristic, serum values, vitamin D levels, bone mineral density measurements, Visual Analog Scala (VAS), Beck Depression Inventory (BDI), Short Form- 36 (SF-36) and Fibromyalgia Impact Questionery Form (FIQ) were determined. Patient and control group were compared in terms of these parameters. Results: There was no significant difference of Vitamin D levels and bone mineral density between case and controls. There was no significant difference between the groups with low and high vitamin D levels in terms of VAS, FIQ, BDI in SF-36 in FMS patients. There was no significant change with regard to VAS, FIQ, BDI, and SF36 between FMS patients with high or low BMD. Conclusion: There is no difference of vitamin D levels and bone mineral density between FMS patients and control group, vitamin D levels and bone mineral density have no effect on pain and quality of life in premenopausal patients with FMS. (From the World of Osteoporosis 2010;16:53-7

ВЯЗКОСТЬ И ЭЛЕКТРОПРОВОДНОСТЬ РАСПЛАВОВ СИСТЕМЫ Bi2O3 – CaO

Objective The aim of this study was to analyze the patient demographics, etiology of limb loss as well as reporting SF-36 scores for microprocessor prosthesis users in Turkish population. Methods We reviewed 72 patients (61 male and 11 female; mean age: 37.7 ± 10.7) with uni-lateral, above knee amputation and a history of regular and microprocessor prosthesis use. All patients were called back for a last follow-up and they were asked to fill a self-administered general health status questionnaire (SF-36). Results According to the SF-36 results; physical component score (PCS) score was 46 ± 7.3 and mental components summary (MCS) score was 46.5 ± 9.1. These scores have statistical similarity with Turkish healthy controls, except SF (social functioning) sub-dimension. PCS score for women microprocessor users were significantly lower than men (43.3 vs. 48.7, p = 0.03), but MCS scores were similar in between genders (46 vs. 48.2, p = 0.13). Conventional prostheses usage time was positively correlated with physical function (PF) scores (r = 0.322, p = 0.010). Microprocessor prosthesis usage time was negatively correlated with role limitations due to emotional problem (RE) scores (r = -0,313, p = 0.009). Conclusion The quality of life surveys were showed that the loss of an extremity have higher physical and psychological impact on women's physical scores. Overall, SF-36 results were similar in microprocessor using amputee's and Turkish normal controls. Level of evidence Level IV, therapeutic study

Sexual dysfunction is related with childhood trauma in female patients with fibromyalgia

ÖZET Giriş: Çocukluk çağı travması (ÇÇT) fibromiyalji sendromunda (FMS) sık görülmektedir ve çeşitli fiziksel ve ruhsal sorunlara neden olabilmektedir. ÇÇT’li bireylerde cinsel işlevler ciddi biçimde etkilenebilmektedir. Bu çalışmada FMS’li kadın hastalarda ÇÇT’nin cinsel işlevlerle ilişkisinin incelenmesi hedeflenmiştir. Yöntem: Çalışmaya ardı-şık olarak başvuran ayaktan FMS’li kadın hastalar (s=49, ortalama yaş: 40.82±6.91) ve yaş ve eğitim durumu açı-sından benzer olan kontrol grubu (s=45, ortalama yaş: 38.60±5.84) alındı. Fibromiyalji Etki Anketi (FEA), Çocuk-luk Çağı Ruhsal Travmaları Ölçeği (CTQ-28), Kadın Cinsel İşlev İndeksi (KCİİ), Beck Depresyon Ölçeği (BDÖ), Durumluk-Sürekli Kaygı Envanteri (DSKE) ve Görsel-Analog Skalası (GAS) değerlendirme aracı olarak kullanıldı. Bulgular: Hastaların sağlıklı kontrollere göre FSFI puanları anlamlı biçimde daha düşüktü. CTQ-28’in toplam, emosyonel istismar, fiziksel istismar, emosyonel ihmal, fiziksel ihmal alt ölçeklerinde hastaların puanları sağlıklı kontrollere göre anlamlı biçimde daha yüksekti. Hasta grubunda FSFI toplam puanı ile CTQ-28 puanı arasında anlamlı derecede negatif bağıntı saptandı. Çoklu hiyerarşik lineer regresyon analizlerinde hasta grubunda CİB’in belirleyicileri FMS’nin ağırlık derecesi ve ÇÇT’ydi. Kontrol grubunda ise regresyon denklemi anlamlı sonuç verme-di. Tartışma: Çocukluk döneminde fiziksel ve emosyonel istismar öyküsü FMS grubunda daha sıktı ve cinsel işlev bozukluğu ile ilişkili bulundu. Erken yaşta travma, stres işlemeyi ve günlük stresle başa çıkmayı etkileyebilir. Sonuçta kişilerarası ilişkilerde aşırı duyarlılığa, cinsel eşle yakınlık kurma zorluğuna ve dolayısıyla cinsel işlev bozukluklarına neden olabilir. (Anadolu Psikiyatri Derg 2013;14:200-9

Mental Symptoms are Related with Impact of the Disease and Impairment in Quality of Life in Female Patients with Fibromyalgia

Objective: Diagnostic criteria of fibromyalgia are revised in 2010 by including mental symptoms and excluding tender points. Although dominance of pain still prevails on the diagnostic criteria, quality of life (QoL) surveys showed that fibromyalgia is strongly associated with mental components of health status, i. e. depression, anxiety and alexithymia. It is aimed to assess determinants of QoL and impact of the disease in patients with fibromyalgia. Methods: Fifty seven female outpatients (mean age +/- SD: 40.93 +/- 6.85; age range: 24-56) with fibromyalgia were enrolled. Fibromyalgia Impact Questionnaire, Short Form-36 QoL survey, Beck Depression Inventory, State-Trait Anxiety Inventory, 20-item Toronto Alexithymia Scale were the measurement tools. Results: Predictor of impact of the disease was alexithymia, particularly, difficulty in identifying feelings (DIF) domain. Predictor of physical health was age, whereas predictors of mental health were depression and trait anxiety. Discussion: Alexithymia, particularly DIF domain may be a more specific predictor of fibromyalgia symptoms, whereas depression and anxiety are more burdensome mental symptoms for fibromyalgia. Pain and mental symptoms are seemed to be processed separately. Targeting mental symptoms provide better treatment outcomes, thus multidisciplinary approaches including psychiatry are necessary

İstanbul'daki Serebral Palsi Olgularının Klinik ve Demografik Özellikleri: Çok Merkezli Çalışma

Amaç: Bu makalenin amacı İstanbul 'daki serebral palsi (SP) olgularının demografik özellikleri, klinik tipi, risk faktörleri ve bazı klinik özelliklerini içeren epidemiyolojik özelliklerini araştırmaktır.Gereç ve Yöntemler: Eğitim, araştırma ve üniversite hastanelerinden oluşan 11 merkezin katıldığı çok merkezli ve retrospektif bir çalışmadır. 2005 ve 2007 yılları arasında eğitim, araştırma ya da üniversite hastanelerinde kayıt edilen SP olgularının demografik ve klinik verileri, İstanbul Serebral Palsi Çalışma Grubunca toplandı.Bulgular: Yaş ortalamaları 7,27±4,63 yıl olan 730 olgu çalışmaya alındı. Olguların 429'u (%58,8) erkek, 301'i (%41,2) kızdı. Klinik tiplendirmede, spastik tip %91, karma tip %3,6, diskinetik tip %3,2 ve ataksik tip % 0,7 olarak bulundu. Olguların %51,9'una yaşamlarının ilk 6 ayı içinde tanı konmuştu, %24,6'sı 2. altı ay; %23,5 'i ise 12. aydan sonra tanı almıştı. Yüzde 32 olguda konuşma bozukluğu, %23,1'inde mental gerilik ve %20,9'unda epilepsi mevcuttu.Sonuç: Ülkemizde SP olguların demografik özellikleri ile ilgili az sayıda çalışma mevcuttur. Bu çalışma, Türkiye'deki SP olgu profilini belirlemede ve prospektif çalışmalara hasta havuzu oluşturmak için bir ön çalışma niteliğindedir.Objective: The objective of this study is to identify epidemiological characteristics of patients with cerebral palsy (CP) in Istanbul, including demographic information, clinical types, risk factors, and some clinical features.Material and Methods: This is a retrospective and multicenter study, with the participation of 11 training and university hospitals in Istanbul. Demographic and clinical data of patients with CP presenting to university and training hospitals in Istanbul between 2005 and 2007 were recorded. Data were collected by the Istanbul Cerebral Palsy Study Group (ICPSG).Results: A total of 730 patients with a mean age of 7.27±4.63 (2-18 years) were enrolled into the study; 429 (58.8%) of the patients were male and 301 (41.2%) were female. During clinical typing, it was seen that 91% of the patients were spastic, 3.6% was mixed, 3.2% was dyskinetic, and 0.7% was ataxic. Also, 51.9 % of the patients had a diagnosis of CP during 0-6 months of age, 24.6% had the diagnosis Sonuç: Ülkemizde SP olguların demografik özellikleri ile ilgili az sayıda çalışma mevcuttur. Bu çalışma, Türkiye'deki SP olgu profilini belirlemede ve prospektif çalışmalara hasta havuzu oluşturmak için bir ön çalışma niteliğindedir

The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye

Background:Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.Aims:To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.Study Design:Multicenter prospective observational clinical study.Methods:This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.Results:As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).Conclusion:Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients