8 research outputs found
(RSS)-[N-Hydroxyethyloxy]-hexafluoroVal–MeLeu–Ala tert-butyl ester
The title compound [systematic name: (2S,5S,8R)-tert-butyl 8-(1,1,1,3,3,3-hexafluoropropan-2-yl)-12-hydroxy-5-isobutyl-2,6-dimethyl-4,7-dioxo-10-oxa-3,6,9-triazadodecanoate], C21H36F6N3O6, is a tripeptide crystallizing in the chiral orthorhombic spacegroup P212121. The absolute configuration (R) of the chiral center in the hexafluorovaline unit is based on the known stereochemistry of MeLeu and Ala (SS). The N-hydroxyethyloxy substituent of hexafluorovaline is positionally disordered [occupancy ratio 0.543 (9):0.457 (9)]. In the solid state structure there are N—H⋯F and N—H⋯O intramolecular hydrogen bonds supporting the coiled structure of this tripeptide with the three hydrophobic substituents on the outside
The quest for planarizing distortions in hydrocarbons: two stereoisomeric 4.5.5.5 fenestranes
According to semiempirical calculations the planarizing distortions in the central C(C)4 substructure of fenestranes, represented as 1, can be enhanced by a variety of structural modifications. Based on these results we selected the 7-hydroxy-c,c,c,c- and c,t,c,c[4.5.5.5]fenestranones 13 and 16 as precursors for the introduction of a bridgehead double bond. The efficient synthesis of these precursors and their chemical transformations are reported. Attempts to activate the hydroxyl group in 16 for introduction of a bridgehead double bond led to the rearrangement of the [4.5.5.5]fenestrane to a triquinacane skeleton. (C) 2011 Elsevier Ltd. All rights reserved