12 research outputs found
Autophagy: Regulation and role in disease
- Author
- Adhami F
- Aguilar V
- Alfred J. Meijer
- Araki M
- Arico S
- Avruch J
- Avruch J
- Axe EL
- Azad MB
- Baquet A
- Bassham DC.
- Bergamini E
- Bergamini E
- Bernales S
- Berry DL
- Beugnet A
- Billington RA
- Blommaart EF
- Blommaart EF
- Blommaart EF
- Boland B
- Bolster DR
- Bonnet S
- Bosoi CR
- Boulahbel H
- Boya P
- Brady NR
- Brunet A
- Byfield MP
- Cadwell K
- Cao Y
- Carloni S
- Carobbio S
- Chan EY
- Chen Y
- Cheng J
- Choi SE
- Choi SL
- Christie GR
- Ciechanover A
- Codogno P
- Cohen E
- Comes F
- Corcelle E
- Corradetti MN
- Corradetti MN
- Cuervo AM.
- Dagda RK
- Daido S
- Dann SG
- Dann SG
- Dardevet D
- De Meyer GR
- Desai BN
- Deter RL
- Ding WX
- Djavaheri-Mergny M
- Drenan RM
- Droge W
- Drummond MJ
- Dubbelhuis PF
- Dumitru CA
- Dunn WA Jr.
- Ebato C
- Eisenberg-Lerner A
- Eskelinen EL
- Eskelinen EL.
- Espert L
- Espert L
- Evans JL
- Fahien LA
- Fang N
- Fang Y
- Farre JC
- Fass E
- Feng Z
- Finlay GA
- Frojdo S
- Fumarola C
- Giusti C
- Gleason CE
- Gohla A
- Gordon PB
- Greer EL
- Guarente L
- Guenther GG
- Guertin DA
- Guigas B
- Gulati P
- Gustafsson AB
- Gwinn DM
- Haigis MC
- Hamacher-Brady A
- Hamacher-Brady A
- Hanada T
- Hannun YA
- Hara K
- Hara T
- Hara-Kuge S
- Hardie DG.
- Hinkovska-Galcheva V
- Hinnebusch AG.
- Holme AL
- Hosokawa N
- Hoyer-Hansen M
- Hundal HS
- Hwang SO
- Hyde R
- Häussinger D
- Itakura E
- Iwata J
- Jahreiss L
- Jensen MV
- Jiang H
- Jiang W
- Jounai N
- Juhasz G
- Juhasz G
- Juhasz G
- Jung CH
- Jung HS
- Kamada Y
- Kanazawa T
- Kang C
- Kaniuk NA
- Kanki T
- Karantza-Wadsworth V
- Karin M.
- Katic M
- Kawamata T
- Khamzina L
- Kihara A
- Kihara A
- Kim E
- Kim I
- Kim JS
- Kim KW
- Kimball SR
- Kimura N
- King MA
- Kissova I
- Kissova I
- Klionsky DJ.
- Kochl R
- Komatsu M
- Komatsu M
- Komatsu M
- Kominami E
- Kopitz J
- Kotoulas OB
- Kouroku Y
- Kourtis N
- Kraft C
- Krause U
- Kroemer G
- Kuma A
- Kundu M
- Lagouge M
- Lalli CA
- Lan F
- Lardeux BR
- Larsen AK
- Lavieu G
- Lee IH
- Lee IH
- Lee SB
- Lemasters JJ
- Lerena C
- Leverve XM
- Levine AJ
- Levine B
- Levine B
- Levine B
- Levine B.
- Li DD
- Li Y
- Liang J
- Liang XH
- Long X
- Lowell BB
- Luiken JJ
- Luiken JJ
- Lum JJ
- Lynch CJ
- Mailloux RJ
- Maiuri MC
- Maiuri MC
- Mammucari C
- Martinez-Vicente M
- Matsui Y
- McBride HM.
- Meijer AJ
- Meijer AJ
- Meijer AJ.
- Melendez A
- Melendez A
- Meley D
- Mijaljica D
- Milne JC
- Miwa S
- Mizushima N
- Mizushima N
- Monastyrska I
- Morimoto N
- Mortimore GE
- Munz C.
- Murphy MP.
- Nakai A
- Nakai A
- Nakatogawa H
- Naples M
- Narendra D
- Nedelsky NB
- Nezis IP
- Nicklin P
- Nishida K
- Nixon RA.
- Nobukuni T
- Nobukuni T
- Noda T
- Norenberg MD
- Novikoff AB
- Nowikovsky K
- Obara K
- Obara K
- Obara K
- Ogata M
- Ogier-Denis E
- Ohsumi Y.
- Opipari AW Jr
- Pacheco CD
- Pankiv S
- Papaconstantinou J.
- Patel S
- Patrice Codogno
- Pattingre S
- Pattingre S
- Pattingre S
- Peraldi P
- Periyasamy-Thandavan S
- Petersen KF
- Petiot A
- Pivtoraiko VN
- Porstmann T
- Poso AR
- Pouyssegur J
- Powers T.
- Prick T
- Proud CG.
- Qadir MA
- Qu X
- Raben N
- Ravikumar B
- Reaven GM.
- Reiling JH
- Ridker PM
- Robertson RP.
- Roccio M
- Roccio M
- Rubinsztein DC.
- Russell SJ
- Sakiyama T
- Salih DA
- Samari HR
- Sancak Y
- Sandoval H
- Sarkar S
- Scarlatti F
- Scarlatti F
- Scarlatti F
- Scherz-Shouval R
- Scherz-Shouval R
- Schiaffino S
- Schriner SE
- Schweers RL
- Scott RC
- Scott RC
- Seglen PO
- Seglen PO
- Selman C
- Sener A
- Settembre C
- Shibata M
- Shigemitsu K
- Shigenaga MK
- Shimizu S
- Smith EM
- Smith EM
- Starkov AA.
- Stemke-Hale K
- Suh Y
- Sun Q
- Sun Y
- Suzuki K
- Suzuki K
- Takagi H
- Tal R
- Talloczy Z
- Tang X
- Tasdemir E
- Tassa A
- Tatar M
- Thoreen CC
- Todde V
- Tracy K
- Tremblay F
- Tsuboi Y
- Tsuchihara K
- Twig G
- Tzatsos A
- Uchiyama Y
- Uhlmann EJ
- Um SH
- Um SH
- Urban J
- van der Horst A
- van Sluijters DA
- vande Velde C
- Veenhuis M
- Vellai T.
- Viana R
- Villena J
- Wang X
- Watson RT
- Wei M
- Willcox BJ
- Wouters BG
- Wu H
- Wullschleger S
- Xiao G.
- Xu G
- Yan Y
- Yen WL
- Yorimitsu T
- Yorimitsu T
- Yorimitsu T
- Yorimitsu T
- Yousefi S
- Yu L
- Yu L
- Yuan H
- Yuan TL
- Zalckvar E
- Zeng X
- Zhang C
- Zhang H
- Zhang W
- Zhao J
- Zhao Z
- Zheng W
- Zhou D
- Zini R
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The role of VEGF and its soluble receptor VEGFR-1 in preterm newborns of preeclamptic mothers with RDS
- Author
- Abdel-Hady S
- ACOG Committee on Obstetric Practice
- Bent AE
- Bowen JR
- Brown KR
- Burak Cakcak
- Catarino C
- Chang EY
- Chen CM
- Compernolle V
- Darlow BA
- Ferrara N
- Ferroni KM
- Galazios G
- Gonul Tezel
- Hasan J
- Healy AM
- Kwon JY
- Levine RJ
- Luft FC
- Maynard SE
- Mustafa Akcakus
- Nihal Oygur
- Osman Oztekin
- Ozgur Tosun
- Pepper MS
- Peters KG
- Roberts JM
- Salih Kalay
- Schlembach D
- Shah DM
- Shifren JL
- Sibai B
- Staff AC
- Thébaud B
- Tubman TR
- Varsila E
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Characterization of hawthorn (Crataegus spp.) genotypes by SSR markers
- Author
- A Emami
- A Wang
- AA Dönmez
- AS Ikhsan
- C Rajeb
- CL Govan
- E Inoue
- E Silfverberg-Dilworth
- E Zietkiewicz
- EY Lo
- F Fernandez-Fernandez
- H Dai
- Hakan Keles
- J Erfani-Moghadam
- JGK Williams
- JJ Doyle
- JK Pritchard
- K Gasic
- K Liu
- KU Yilmaz
- L Fan
- M Beigmohamadi
- M Hemmat
- M Scheulke
- MS Rahmani
- Murat GĂĽney
- N MirAli
- O GĂĽlĹźen
- P Guilford
- P Vos
- R Liebhard
- R Peakall
- R Testolin
- S Ercisli
- S Fang
- S Kafkas
- S Kafkas
- S Khiari
- S Moriya
- S Oddou-Muratorio
- S Serce
- S ZaloÄźlu
- Salih Kafkas
- SC Hokanson
- SD Tanksley
- Servet Aras
- Sezai ErciĹźli
- SM Potts
- T Yamamoto
- Y Han
- Y Han
- Y Zhang
- YZ Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Immunomodulatory effects of anti-angiogenic drugs
- Author
- A Kreutzman
- A Nencioni
- A Nencioni
- A Nencioni
- AE Schade
- B Blanco
- C Alfaro
- C Berges
- C Berges
- C Borg
- CK Fraser
- DC Birle
- DH Kim
- EY Woo
- F Fei
- F Fei
- F Fei
- H Wang
- J Adams
- J Baselga
- J Chen
- J Ozao-Choy
- J Salih
- J Shimizu
- J Taieb
- J Wada
- J Zhang
- J Zhang
- JB Hamner
- JC Yang
- JS Ko
- JS Ko
- K Neubert
- K Zhu
- KL Osusky
- KM Brauer
- KR Molhoek
- M Basler
- M Mohty
- M Moschetta
- MM Hipp
- R Erber
- R Houben
- R Seggewiss
- R Weichsel
- S Appel
- S Appel
- S Blake
- S Meister
- S Mustjoki
- S Onizuka
- S Salceda
- T Hideshima
- T Osada
- TJ Curiel
- U Heider
- W Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Kiwifruit Waste and Novel Products Made from Kiwifruit Waste: Uses, Composition and Analysis
- Author
- A Scalbert
- A Testoni
- AB Grace
- AE Percy
- Anonymous
- Anonymous
- Anonymous
- Anonymous
- AR Ferguson
- AR Ferguson
- AR Ferguson
- AS Wehmeyer
- C Balestrieri
- C Lintas
- CJ Clark
- CJ Clark
- CJ Clark
- CO Perera
- D Castaldo
- DA Heatherbell
- DA Heatherbell
- DA Lewis
- DJW Burns
- DM Dawson
- E Pesis
- E Peterlunger
- E Salih
- EA MacRae
- EA MacRae
- EA MacRae
- EF Walton
- EL Wilson
- EL Wilson
- EN Baker
- EY Park
- F Gorini
- FD Gunstone
- FR Visser
- G Crivelli
- G Fischböck
- G Hopkirk
- G Hopkirk
- G Préstamo
- G Préstamo
- G Sarath
- G Strachan
- GA Fenton
- GC Galletti
- GL Robertson
- GR Takeoka
- GS Lawes
- GS Ross
- GS Smith
- H Dawes
- H Maarse
- H Ogawa
- H Ogawa
- H Young
- H Young
- H Young
- I Okuse
- I Soda
- IJ Warrington
- J Arthur
- J Schaefer
- JA Beutel
- JH Bowen
- JP Bartley
- JT Craig
- K Tatsuka
- KJ Scott
- KL Math
- KR Lynn
- L Palmieri
- L Ragozza
- LC Leod
- LM Withy
- M Prasad
- M Rosa
- M Taylor
- MA Martin-Cabrejas
- MC Jarvis
- MJ Boland
- MJ Boland
- MJ Boland
- MJ Kennedy
- MJ Kennedy
- MP Cano
- N Lodge
- N Lodge
- N Lodge
- N Lodge
- NK Given
- PC Fourie
- R Smith
- RBH Wills
- RH Newman
- RH Newman
- RH Newman
- RJ Davies
- RJ Redgewell
- RJ Redgwell
- RJ Redgwell
- RJ Redgwell
- RJ Redgwell
- RJ Redgwell
- RJ Redgwell
- RJ Steele
- RL Cotter
- RL Johnson
- RL Johnson
- RW Earp
- S Boyes
- S Matsumoto
- S Matsunaga
- SA Spraggon
- SJ Opella
- SN Dawes
- SR Tello-Solls
- T Yamaguchi
- UM Praekelt
- VJ Paterson
- W Paul
- WP Snelgar
- YD Hang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study
Treatment of Giardiasis
- Author
- Addiss D. G.
- Addiss D. G.
- Agarwal A. K.
- Al-Waili N. S.
- Al-Waili N. S. D.
- American Academy of Pediatrics Committee on Drugs
- Andersson T.
- Andrews B. J.
- Andrews B. J.
- Andrews B. J.
- Awadalla H. N.
- Bakshi J. S.
- Bartlett A. V.
- Bassily S.
- Bassily S.
- Baveja U. K.
- Bean N. H.
- Beard C. M.
- Beard C. M.
- Berget A.
- Bingham A. K.
- Black R. E.
- Boreham P. F. L.
- Boreham P. F. L.
- Boreham P. F. L.
- Boreham P. F. L.
- Boreham P. F. L.
- Brodsky R. E.
- Brown D. M.
- Bulut B. U.
- Buret A.
- Buret A.
- Burtin P.
- Butcher P. D.
- Cacopardo B.
- Calzada F.
- Carter C. H.
- Chávez B.
- Clark J. T.
- Craft J. C.
- Craun G. F.
- Crouch A. A.
- Crouch A. A.
- Darbon A.
- Davidson R. A.
- Djamiatun K.
- Dobell C.
- Doumbo O.
- Duncombe V. M.
- DuPont H. L.
- Durel P.
- Dutta A. K.
- Edlind T. D.
- Edwards D. I.
- Elliott A. M.
- Erlandsen S. L.
- Erlich J. H.
- Ey P. L.
- Falagas M. E.
- Farbey M. D.
- Farthing M. J. G.
- Farthing M. J. G.
- Farthing M. J. G.
- Farthing M. J. G.
- Farthing M. J. G.
- Farthing M. J. G.
- Garg B. K.
- GascĂłn J.
- Gazder A. J.
- Gillin F. D.
- Gillis J. C.
- Gilman R. H.
- Goka A. K. J.
- Goldman P.
- Goodgame R. W.
- Gorbea Robles M. C.
- Gupta M. C.
- Hall A.
- Hartman H. R.
- Hartong W. A.
- Herzog D.
- Hetsko M. L.
- Heyworth M. F.
- Hiatt R. A.
- Hill D. R.
- Hill D. R.
- Hill D. R.
- Hill D. R.
- Inge P. M. G.
- Isaac-Renton J.
- Isaac-Renton J. L.
- Ish-Horowicz M.
- Jephcott A. E.
- Johns T.
- Jokipii A. M. M.
- Jokipii A. M. M.
- Jokipii L.
- Jokipii L.
- Jokipii L.
- Jokipii L.
- Jokipii L.
- Kalyci A. G.
- Kang E. W.
- Kavousi S.
- Kettis A. A.
- Kollaritsch H.
- Kramer M. H.
- Kreutner A. K.
- Kusumi R. K.
- Kuzmicki R.
- Kyrönseppä H.
- Lau A. H.
- Laughon B. E.
- Lengerich E. J.
- Lerman S. J.
- Levi G. C.
- Levine W. C.
- Lindquist H. D.
- Liu L. X.
- MacDonald T. T.
- Mahbubani M. H.
- Mahmud M. A.
- Majewska A. C.
- Mank T. G.
- Markell E. K.
- McIntyre P.
- Meingasser J. G.
- Meloni B. P.
- Meyer E. A.
- Meyers J. D.
- Mintz E. D.
- Misra P. K.
- Miyares C.
- Monis P. T.
- Moore G. T.
- Morrow A. L.
- Muller M.
- Murphy T. V.
- Namgung R.
- Nash T. E.
- Nash T. E.
- Nayak N.
- Notis W. M.
- Oberhuber G.
- Oren B.
- Osterholm M. T.
- Paget T. A.
- Paintlia A. S.
- Palomino H.
- Pearce D. A.
- Pengsaa K.
- Pickering L. K.
- Polis M. A.
- Popovic O. S.
- Pungpak S.
- Quick R.
- Quinn T. C.
- Quiros-Buelna E.
- Rauch A. M.
- Reiner D. S.
- Reinthaler F. F.
- Rendtorff R. C.
- Reynoldson J. A.
- Reynoldson J. A.
- Rodriguez-Garcia R.
- Roe F. J. C.
- Romero Cabello R.
- Romero-Cabello R.
- Rosa F. W.
- Rosen F. S.
- Rossignol J. F.
- Rotblatt M. D.
- Rousham E. K.
- Sabchareon A.
- Sagi E. F.
- Salih S. Y.
- Sealy D. P.
- Smith P. D.
- Smith P. D.
- Solomons N. W.
- Steketee R. W.
- Sullivan P. S.
- Suntornpoch V.
- Taylor G. D.
- Thiriat L.
- Thompson R. C. A.
- Thompson S. C.
- Townson S. M.
- Townson S. M.
- Tripathi D. M.
- Underdown B. J.
- Upcroft J.
- Upcroft J.
- Upcroft J. A.
- Upcroft J. A.
- Upcroft J. A.
- Upcroft J. A.
- Venkatesan P.
- Voogd C. E.
- Ward W.
- Webster B. H.
- Wolfe M. S.
- Wolfe M. S.
- World Health Organization Informal Working Group on Echinococcosis
- Yardley J. H.
- Youssef M. Y. M.
- Zaat J. O.
- Ziv G.
- Publication venue
- American Society for Microbiology
- Publication date
- 01/01/2001
- Field of study
Giardia lamblia is both the most common intestinal parasite in the United States and a frequent cause of diarrheal illness throughout the world. In spite of its recognition as an important human pathogen, there have been relatively few agents used in therapy. This paper discusses each class of drugs used in treatment, along with their mechanism of action, in vitro and clinical efficacy, and side effects and contraindications. Recommendations are made for the preferred treatment in different clinical situations. The greatest clinical experience is with the nitroimidazole drugs, i.e., metronidazole, tinidazole, and ornidazole, which are highly effective. A 5- to 7-day course of metronidazole can be expected to cure over 90% of individuals, and a single dose of tinidazole or ornidazole will cure a similar number. Quinacrine, which is no longer produced in the United States, has excellent efficacy but may be poorly tolerated, especially in children. Furazolidone is an effective alternative but must be administered four times a day for 7 to 10 days. Paromomycin may be used during early pregnancy, because it is not systematically absorbed, but it is not always effective. Patients who have resistant infection can usually be cured by a prolonged course of treatment with a combination of a nitroimidazole with quinacrine
Role of Innate Immunity in Cancers and Antitumor Response
- Author
- A Cerwenka
- A Glasner
- A Iwasaki
- A Rot
- A Sica
- AC Hayday
- AC Johnsen
- AD Gregory
- AK Lichtenstein
- AK Singh
- AS Dighe
- AV Thompson
- B Cambien
- B Seliger
- BA Teicher
- BZ Qian
- BZ Qian
- C Bottino
- C Bottino
- C Cantoni
- C Curcio
- C Shi
- C Stolfi
- C Watts
- CA Alvarez-Breckenridge
- CA Hunter
- CT Mortia
- D Cosman
- D Hawiger
- D Kabelitz
- D Piccioli
- D Sancho
- DA Hume
- DD Billadeau
- DG DeNardo
- E Azenshtein
- EY Lin
- F Balkwill
- F Gerosa
- F Ghiringhelli
- G Chen
- G Dranoff
- G Luboshits
- G Makin
- G Peng
- GC Blobe
- GJ Bancroft
- GP Dunn
- GP Dunn
- GP Dunn
- GY Chen
- H Kato
- H Okazawa
- H Poeck
- H Suttmann
- HR Salih
- HT Khong
- I Fricke
- I Gresser
- I Kryczek
- IC Allen
- J Condeelis
- J Cui
- J Gołab
- J MacMicking
- J Silva Correia Da
- JA Brown
- JB Mumm
- JC Steel
- JE Boudreau
- JG Sinkovics
- JL Langowski
- JM Blander
- JM Elliott
- JR Conejo-Garcia
- JR Passweg
- JY Ting
- K Ebata
- K KĂĽbler
- K Palucka
- K Schroder
- K Schroder
- KA Stormes
- KM Smith
- L Apetoh
- L Chen
- L Chen
- L Dolcetti
- L Moretta
- L Ruggeri
- L Wang
- L Yang
- L Zamai
- LM Wakefield
- M Bléry
- M Brandes
- M Girardi
- M Girardi
- M Jinushi
- M Jinushi
- M Jinushi
- M Locati
- M Miyanishi
- M Osman
- M Palma De
- M Taniguchi
- M Terabe
- M Terabe
- M Vecchio Del
- M Wobser
- MA Meraz
- MD Vesely
- MJ Robertson
- MJ Smyth
- MJ Smyth
- MJ Smyth
- MJ Smyth
- MO Li
- MP Chao
- MR Elliott
- MS Diamond
- MT Chow
- MT Orr
- N Lapteva
- NY Crowe
- O Akbari
- P Mirandola
- R Castriconi
- R Castriconi
- R Hanayama
- R Soiffer
- RM Steinman
- RT Robinson
- S Bauer
- S Chiba
- S Gasser
- S Gillessen
- S Hiratsuka
- S Kim
- S Kim
- S Pervaiz
- S Wu
- SA Rosenberg
- SB Willingham
- SI Grivennikov
- SK Biswas
- T Akazawa
- T Kawai
- T Nakano
- T Ueno
- T Walzer
- TH Geijtenbeek
- TJ Curiel
- TJ Curiel
- V Goede
- V Groh
- V Shankaran
- W Zou
- WM Yokoyama
- Y Iwai
- Y Iwai
- Y Kubota
- Y Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Postgraduate ethics training programs: a systematic scoping review
- Author
- A Fanous
- A Haig
- A Riquelme
- A Robb
- A Sutton
- A Thomas
- AA Kon
- AC Tricco
- AD Dingle
- AF Cook
- AJ Grace
- AM Mohamed
- AV Campbell
- B Brajenovic-Milic
- B Hodges
- B Kotzee
- B Tolchin
- B Viswanath
- BC Walsh
- BK Stoff
- C Belling
- C Boden
- C Bok
- C Charles
- C Strong
- Challis M. AMEE Medical Education G
- CI Tsao
- CJ Watling
- CJ Watling
- CL Cummings
- CPMSL Van Der Vleuten
- CS Kow
- CW Lang
- CWSC Wen Jie Chua
- D Levac
- D Soemantri
- D Steinemann
- DLPS Lorenzetti
- DP Sulmasy
- DZ Buchman
- E Grossman
- ED Pellegrino
- ER Nicholas Mays
- EV Beresin
- EY Liu
- F Al-Mahroos
- F Howard
- F Howard
- F Patterson
- FM Matos
- FW Hafferty
- GP Moore
- H Arksey
- H Birden
- H Li
- HA Taylor
- HB Sherman
- HF Hsieh
- HJ Silverman
- HM Manson
- J Andre
- J Benbassat
- J Byrne
- J Goldie
- J Malek
- J Norcini
- J Norcini
- J Schonrock-Adema
- J Veloski
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- L Bercovitch
- L Bercovitch
- L Cheung
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- L Lohfeld
- LHET Nur Haidah Ahmad Kamal
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study
- Author
- Abbas Z
- Abburu S
- Abdelhadi M
- Abdikadir HR
- Abdulmajid A
- Abid A
- Abid H
- Abuhussein N
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- Zuhair M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background
Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery.
Methods
Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals.
Results
From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560).
Conclusions
Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery