8 research outputs found
Cultural landscapes of the future: using agent-based modeling to discuss and develop the use and management of the cultural landscape of South West Devon
Gravimetric geoid modeling from the combination of satellite gravity model, terrestrial and airborne gravity data: a case study in the mountainous area, Colorado
Comparison and evaluation of high-resolution marine gravity recovery via sea surface heights or sea surface slopes
Quality assessment of global gravity field models in coastal zones: A case study using astrogeodetic vertical deflections in Istanbul, Turkey
The provenance signal of climate–tectonic interactions in the evolving St. Elias orogen: framework component analysis and pyroxene and epidote single grain geochemistry of sediments from IODP 341 sites U1417 and U1418
Management of Itch in Atopic Dermatitis
Atopic dermatitis (AD) is the most common itchy dermatosis that affects millions of children and adults worldwide. Chronic itch in this condition has significant impact on measures of quality of life, such as sleep. Treating itch in AD has been challenging for decades, but new drugs have emerged in the last year with significant anti-pruritic effect. The optimal treatment regimen for atopic itch addresses barrier dysfunction, inflammation, neural hypersensitivity, and the itch–scratch cycle. Topical moisturizers remain the foundation of treatment and should be used by all patients with AD-associated pruritus. Step-wise therapy, from topical anti-inflammatory creams to systemic monoclonal antibodies and immunosuppressants, is recommended. There are multiple adjuvant therapies that can be used, especially to target itch in the setting of minimal skin inflammation. Finally, patient education, sleep management, and stress relief are important components to optimize outcomes. This review assesses the latest advances and treatment recommendations for pruritus in AD. Finally, suggested therapeutic ladders and emerging treatments are discussed