The comparison of bone mineral density in primary hyperparathyroidim, vitamin D induced secondary hyperparathyroidism, and patients with both condition: a single center experience

Background: To compare bone mineral densities via dual energy X-ray absorptiometry method (DXA) between various hyperparathyroidism (HPT) types such as primary, vitamin D induced secondary, and both conditions.Methods: Participants who were aged between 18-45 years and had elevated parathyroid hormone levels were included. After initial evaluations, patients were divided into 3 groups according to diagnoses: primary HPT (pHPT), vitamin D induced secondary HPT (sHPT), and combined (primary+secondary) one. In addition to the bone mineral density (BMD), demographic and laboratory datas were recorded.Results: Of 166 patients, 147 of the patients were female, 19 were male, and average age was 38.10±7.24 years. Significant difference was found in terms of age (p=0.03) between pHPT and sHPT. Blood calcium, PTH, 25-OH vitamin D, and daily urine calcium excretion levels were significantly higher and phosphorus levels were lower in the pHPT group compared to the sHPT and combined disease group. Both T and Z scores of the pHPT group were significantly lower than the sHPT group especially in the lumbar region. However, no significant difference was noted between pHPT and combined disease group with respect to T and Z scores in all regions.Conclusions: The results of this study indicate that pHPT has a significantly worse impact on skeletal mineral density particularly in the lumbar region than sHPT. The addition of vitamin D deficiency to the clinical picture seems to have no significant influence on BMD in pHPT. To confirm and clarify these findings, prospective studies with larger number of participants are needed

Oncocytic neoplasms; rare adrenocortical tumours — a report of eleven patients

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature. Material and methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Those who underwent surgery and pathological diagnosis of oncocytoma (n = 11) were included to the study. The demographic, clinical, pathological, radiological, and laboratory features were evaluated. Results: Of these 11 patients, 54.5% (n = 6) were female and 45.5% (n = 5) were male. They aged between 31 and 76 years (45.36 ± 13.68). Five (45.5%) of the masses showed endocrinological activity and were more frequent in women. The masses were 25–130 (57.63 ± 34.04) mm in width and 20–100 (47.82 ± 28.95) mm in length. Seven (63.6%) oncocytomas were classified as benign and the remainder as having uncertain malignant potential according to Lin-Weiss-Bisceglia criteria. Mean duration of follow-up were 24.8 (6–60) months and 38.2 (15–82) months, respectively. Conclusions: Because there are no unique clinical and imaging characteristics differentiating adrenal oncocytomas from other types of adrenal masses, it should be kept in mind in differential diagnosis of adrenal masses, especially large ones and those suspicious for adrenocortical carcinoma

A Rare Cause of Fatty Liver and Elevated Aminotransferase Levels: Chanarin-Dorfman Syndrome: A Case Report

Chanarin-Dorfman syndrome is a rare, inherited metabolic disorder of neutral lipid storage characterized by ichthyosis, lipid vacuoles in leukocytes, and involvement of several internal organs, mostly the liver. Since the initial case was reported by Dorfman in 1974, nearly 50 cases have been reported, and the majority were from Middle East countries. Here, we report a 20-year-old patient with ichthyosis from Turkey, diagnosed as Chanarin-Dorfman syndrome presented with asypmtomatic elevated transaminases and hepatosteatosis, and also briefly review the updated clinical implications and management of this rarely seen syndrome. Prompt diagnosis of this syndrome avoids further unnecessary investigations in patients with ichthyosi

Evaluation of the awareness regarding Type 2 Diabetes, its management and adverse effects of the treatment among the patients with Type 2 Diabetes

Introduction: Diabetes Mellitus (DM) management requires not only continuous medical care but also risk reduction strategies to prevent complications. Improving patients’ knowledge and awareness about DM and diabetes-related complications (DRC) is crucial for the management of DM. Increased awareness about DM and DRC, which leads to an eagerness to follow-up diet plans, and lifestyle modifications would help us to establish patient-specific goals. In this study, we would like to determine the awareness levels of diabetic patients about DM, DM management and DRC.Methods: Total of 300 adult patients (179 female, 121 male) with type 2 Diabetes Mellitus (T2DM) were included in this study. The data was collected through a survey based on face-to-face interviews. Total Survey score (TSP) for each participant was calculated by taking 1 point for each correct answer and TSP interval was evaluated between 0-24 points.. Results: The score of women was higher than that of men (14.72±3.14 vs. 13.07±3.30, p lt;0.001). Patients who did not work were more aware (14.53±3.22 vs. 13.64±3.31, p = 0.019). No significant difference in terms of awareness was observed between low educated and high-educated participants. Patients who had insulin in their treatment combination, anti-hypertensive, and lipid-lowering drug user had significantly higher TSP scores. A significant correlation was observed in BMI, HC, DBP, and age of Diabetes with awareness. Conclusions: The mean awareness score of the patients who participated in our study was 14 points. Since the maximum score that can be obtained at the highest awareness level is 24, the awareness level of our patients can be evaluated as 58%. Considering the morbidity, mortality and economic costs associated with diabetes, it can be said that more attention should be paid to patient education in order to achieve higher treatment success

Charakter wzrostu gruczolaków przysadki typu prolactinoma zależy od stężenia prolaktyny i płci pacjentów, ale nie od wartości wskaźnika Ki-67

Introduction: The objective of this study was to investigate the effects of some clinical and pathological features of prolactinomas on tumour behaviour.Material and methods: The study included 113 patients with prolactinoma (27 male, 86 female), with a mean age at diagnosis of 34.4 ± 10.0 years (40.3 ± 12.6 in males, 32.6 ± 8.3 in females). Patients were grouped as invasive or non-invasive according to radiological imaging findings. Ki-67 levels were evaluated if possible.Results: The mean adenoma size (longest dimension) was 38.6 ± 21.6 mm and 10.8 ± 9.4 mm in male and female patients. Pre-treatment serum levels of prolactin were defined as mean 1,926 ± 6,662 ng/mL in all, 124.8 ± 63.4 and 4,675 ± 10,049 ng/mL in the noninvasive and invasive groups (p < 0.05). A positive correlation was found between the serum levels of prolactin and tumour size. The rate of patients with Ki-67 ≥ 0.03 was 37.5% and 47.8% in the noninvasive and invasive groups. The reduction rates were 60.8% and 80.4% in tumour sizes and 81.1% and 93.8% in prolactin level in the noninvasive and invasive groups, respectively, (p < 0.05).Conclusions: We found a strong correlation between prolactin levels and invasiveness in male patients compared to females. Ki-67 index was not found to have a place in defining the prognosis.Wstęp: Celem badania była analiza zależności pomiędzy wybranymi danymi klinicznymi i cechami patomorfologicznymi a przebiegiem klinicznym u pacjentów z gruczolakiem przysadki wydzielającym prolaktynę (prolactinoma)/lub z gruczolakiem prolaktynowym przysadki.Materiał i metody: Do badania włączono 113 pacjentów, u których rozpoznano guzy typu prolactinoma (27 mężczyzn, 86 kobiet). Średni wiek pacjentów w momencie rozpoznania wynosił 34,4 ± 10,0 lat (40,3 ± 12,6 u mężczyzn, 32,6 ± 8,3 u kobiet). Na podstawie badań obrazowych/badań radiologicznych guzów pacjentów podzielono na dwie grupy — z gruczolakami inwazyjnymi i gruczolakami nieinwazyjnymi. Wskaźnik Ki-67 oceniono w tych preparatch, gdzie było to możliwe.Wyniki: Średni wymiar gruczolaka (mierzony według najdłuższej osi) wyniósł 38,6 ± 21,6 mm u mężczyzn i 10,8 ± 9,4 mm u kobiet. Średnie stężenie prolaktyny w surowicy przed leczeniem wynosiło 1926 ± 6662 ng/ml w całej grupie badanej, 124,8 ± 63,4 w grupie guzów nienaciekających i 4675 ± 10049 ng/ml w przypadku guzów naciekających (p < 0,05). Stwierdzono istnienie dodatniej zależności pomiędzy stężeniem prolaktyny w surowicy i wymiarem guza. Odsetki pacjentów, u których wartość wskaźnika Ki-67 była duża (≥ 0,03) wyniosły odpowiednio 37,5% w grupie guzów nienaciekających i 47,8% w grupie guzów naciekających. W grupie nowotworów nienaciekających zmniejszenie wymiarów gruczolaka nastąpiło u 60,8% a zmniejszenie stężenia prolaktyny u 81,1% pacjentów, natomiast w grupie guzów naciekających odpowiednie wartości wyniosły 80,4% i 93,8% (p < 0,05).Wnioski: U mężczyzn stwierdzono istnienie wyraźnej zależności pomiędzy stężeniem prolaktyny w surowicy a charakterem naciekającym guza, czego nie wykazano u kobiet. Wskaźnik Ki-67 nie miał związku z charakterem wzrostu guza

A Preliminary Study on The Chemical Structure of Vicia saliva L. Accessions Collected From Natural Flora of European Part of Turkey

The objective of this study was to determine chemical composition of 24 common vetch (Vicia sativa L.) accessions, collected from natural flora in European part of Turkey. The field experiment was carried out in the 2015-2016 growing season at field experimental area of Tekirdag Namik Kemal University, Agricultural Faculty, Field Crops Department in Tekirdag/Turkey. In this study, chemical structure (nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg), copper (Cu). zinc (Zn). iron (Fe), and manganese(Mn) content) of common vetch accessions were determined on hay. Chemical composition content was statistically significantly different (P <= 0.01) between accessions. According to the results obtained from field experiments, N, P, K, Ca, Mg, Cu, Zn, Fe, and Mn content of common vetch accessions varied between 0.95-3.14 %, 0.84-3.65 %, 0.22-2.44 %, 0.89-2.85 %, 0.23-0.74 %, 0.15-7.80 ppm, 0.10-5.30 ppm, 43.00-2295.20 ppm, 3.08-17.50 ppm, respectively. A wide variation was observed among common vetch accessions used in the study for N, P, K, Ca, Mg, Cu, Zn, Fe, and Mn content. Tetany and Ca/P rates of accessions changed from 0.13 - 1.54 and 0.28 - 2.19, respectively. The tetany and Ca/P rates of common vetch accessions are within suitable values for animal feeding. Ca/P ratio is above the limit value only in accessions 15-2 and 14O04. According to the correlation analysis, N was positively and significantly correlated with P, K, Mg, Cu and Fe. Similarly, P was positively and significantly correlated with N, K and Fe. Magnesium was positively and significantly correlated with N, Ca, Cu, Fe and Mn. Iron was positively and significantly correlated with N, P, Ca, Mg and Cu. As a result, accession 15K17 and 33 were identified as common vetch accessions with high mineral nutrition content.Scientific and Technological Research Council of Turkey (TUBITAK) [TOVAG-1130297]; Tekirdag Namik Kemal University Scientific Research Projects Coordinatorship [NKUBAP.00.24.AR.14.10]This study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) Grant (TOVAG-1130297) and Tekirdag Namik Kemal University Scientific Research Projects Coordinatorship (NKUBAP.00.24.AR.14.10)