64 research outputs found
Accurate peak list extraction from proteomic mass spectra for identification and profiling studies
<p>Abstract</p> <p>Background</p> <p>Mass spectrometry is an essential technique in proteomics both to identify the proteins of a biological sample and to compare proteomic profiles of different samples. In both cases, the main phase of the data analysis is the procedure to extract the significant features from a mass spectrum. Its final output is the so-called peak list which contains the mass, the charge and the intensity of every detected biomolecule. The main steps of the peak list extraction procedure are usually preprocessing, peak detection, peak selection, charge determination and monoisotoping operation.</p> <p>Results</p> <p>This paper describes an original algorithm for peak list extraction from low and high resolution mass spectra. It has been developed principally to improve the precision of peak extraction in comparison to other reference algorithms. It contains many innovative features among which a sophisticated method for managing the overlapping isotopic distributions.</p> <p>Conclusions</p> <p>The performances of the basic version of the algorithm and of its optional functionalities have been evaluated in this paper on both SELDI-TOF, MALDI-TOF and ESI-FTICR ECD mass spectra. Executable files of MassSpec, a MATLAB implementation of the peak list extraction procedure for Windows and Linux systems, can be downloaded free of charge for nonprofit institutions from the following web site: <url>http://aimed11.unipv.it/MassSpec</url></p
Volition-adaptive control for gait training using wearable exoskeleton: preliminary tests with incomplete spinal cord injury individuals
Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus
The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
Predictive Value of Penile Dynamic Colour Duplex Doppler Ultrasound Parameters in Patients with Post-Traumatic Urethral Stricture
Finasteride for androgenetic alopecia is not associated with sexual dysfunction: a survey‐based, single‐centre, controlled study
In vitro culture of intramolluscan stages of the avian schistosomeTrichobilharzia ocellata
Sexual and prostate health in a longitudinal, European cohort study: The Registry of Hypogonadism in Men (RHYME).
A classification based on peak systolic velocity and end diastolic velocity predicts sildenafil citrate success
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