Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer

After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes' B and C disease. Similarly, the modified Glasgow Prognostic Score (mGPS) based on biochemical criteria has also been validated. This study compares both the scores in patients undergoing curative resection of colon cancer. A total of 244 patients underwent elective resection between 1997 and 2005. The PI was constructed from pathological reports; the mGPS was measured pre-operatively. The median follow-up was 67 months (minimum 36 months) during which 109 patients died; 68 of them from cancer. On multivariate analysis of age, Dukes' stage, PI and mGPS, age (hazard ratio, HR, 1.74, P=0.001), Dukes' stage (HR, 3.63, P<0.001), PI (HR, 2.05, P=0.010) and mGPS (HR, 2.34, P<0.001) were associated independently with cancer-specific survival. Three-year cancer-specific survival rates for Dukes' B patients with the low-risk PI were 98, 92 and 82% for the mGPS of 0, 1 and 2, respectively (P<0.05). The high-risk PI population is small, in particular for Dukes' B disease (9%). The mGPS further stratifies those patients classified as low risk by the PI. Combining both the scoring systems could identify patients who have undergone curative surgery but are at high-risk of cancer-related death, therefore guiding management and trial stratification

Model and experiences of initiating collaboration with traditional healers in validation of ethnomedicines for HIV/AIDS in Namibia

Many people with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) in Namibia have access to antiretroviral drugs but some still use traditional medicines to treat opportunistic infections and offset side-effects from antiretroviral medication. Namibia has a rich biodiversity of indigenous plants that could contain novel anti-HIV agents. However, such medicinal plants have not been identified and properly documented. Various ethnomedicines used to treat HIV/AIDS opportunistic infections have not been scientifically validated for safety and efficacy. These limitations are mostly attributable to the lack of collaboration between biomedical scientists and traditional healers. This paper presents a five-step contextual model for initiating collaboration with Namibian traditional healers in order that candidate plants that may contain novel anti-HIV agents are identified, and traditional medicines used to treat HIV/AIDS opportunistic infections are subjected to scientific validation. The model includes key structures and processes used to initiate collaboration with traditional healers in Namibia; namely, the National Biosciences Forum, a steering committee with the University of Namibia (UNAM) as the focal point, a study tour to Zambia and South Africa where other collaborative frameworks were examined, commemorations of the African Traditional Medicine Day (ATMD), and consultations with stakeholders in north-eastern Namibia. Experiences from these structures and processes are discussed. All traditional healers in north-eastern Namibia were willing to collaborate with UNAM in order that their traditional medicines could be subjected to scientific validation. The current study provides a framework for future collaboration with traditional healers and the selection of candidate anti-HIV medicinal plants and ethnomedicines for scientific testing in Namibia

Isospin violating dark matter in Stückelberg portal scenarios

Journal of High Energy Physics 2015.4 (2015): 175 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Hidden sector scenarios in which dark matter (DM) interacts with the Standard Model matter fields through the exchange of massive Z′ bosons are well motivated by certain string theory constructions. In this work, we thoroughly study the phenomenological aspects of such scenarios and find that they present a clear and testable consequence for direct DM searches. We show that such string motivated Stückelberg portals naturally lead to isospin violating interactions of DM particles with nuclei. We find that the relations between the DM coupling to neutrons and protons for both, spin-independent (fn/fp) and spin-dependent (an/ap) interactions, are very flexible depending on the charges of the quarks under the extra U(1) gauge groups. We show that within this construction these ratios are generically different from ±1 (i.e. different couplings to protons and neutrons) leading to a potentially measurable distinction from other popular portals. Finally, we incorporate bounds from searches for dijet and dilepton resonances at the LHC as well as LUX bounds on the elastic scattering of DM off nucleons to determine the experimentally allowed values of fn/fp and an/apThe authors are grateful to D. G. Cerdeño, L. Ibañez, F. Kahlhoefer and G. Shiu for useful comments. V.M.L. and M.P. would like to thank the support of the European Union under the ERC Advanced Grant SPLE under contract ERC-2012-ADG-20120216-320421, the support of the Consolider-Ingenio 2010 programme under grant MULTIDARK CSD2009-00064, the Spanish MICINN under Grant No. FPA2012-34694, the Spanish MINECO “Centro de excelencia Severo Ochoa Program” under Grant No. SEV-2012-0249, and the Community of Madrid under Grant No. HEPHACOS S2009/ESP-1473. P.S. would like to thank DESY, the University of Hamburg, and the Hong Kong IAS for kind hospitality during the completion of this work. He acknowledges support from the DOE grant DEFG-02-95ER40896 and the HKRGC grant HKUST4/CRF/13G, 604231, as well as the Collaborative Research Center SFB676 of the DFG at the University of Hambur

Bioavailable Trace Metals in Neurological Diseases

Medical treatment in Wilson’s disease includes chelators (d-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first being a de-coppering phase and the second a maintenance one. The best therapeutic approach remains controversial, as only a few non-controlled trials have compared these treatments. During the initial phase, progressive increase of chelators’ doses adjusted to exchangeable copper and urinary copper might help to avoid neurological deterioration. Liver transplantation is indicated in acute fulminant liver failure and decompensated cirrhosis; in cases of neurologic deterioration, it must be individually discussed. During the maintenance phase, the most important challenge is to obtain a good adherence to lifelong medical therapy. Neurodegenerative diseases that lead to a mislocalisation of iron can be caused by a culmination of localised overload (pro-oxidant siderosis) and localised deficiency (metabolic distress). A new therapeutic concept with conservative iron chelation rescues iron-overloaded neurons by scavenging labile iron and, by delivering this chelated metal to endogenous apo-transferrin, allows iron redistribution to avoid systemic loss of iron

Interaction of the Beryllium Cation with Molecular Hydrogen and Deuterium

The structural and spectroscopic properties of the Be(+)-H2 and Be(+)-D2 electrostatic complexes are investigated theoretically. A three-dimensional ground-state potential energy surface is generated ab initio at the CCSD(T) level and used for calculating the lower rovibrational energy levels variationally. The minimum of the potential energy surface corresponds to a well depth of 3168 cm(-1), an intermolecular separation of 1.776 Å, with the bond of the H2 subunit being 0.027 Å longer than for the free molecule. Taking vibrational zero point energy into account, the complexes containing para H2 and ortho D2 are predicted to have dissociation energies of 2678 and 2786 cm(-1), respectively. The νHH band of Be(+)-H2 is predicted to be red-shifted from the free dihydrogen transition by -323 cm(-1), whereas the corresponding shift for Be(+)-D2 is predicted to be -229 cm(-1). The dissociation energy of the Be(+)-D2 complex is calculated to be slightly higher than the energy required to vibrationally excite the D2 subunit, raising the possibility that the onset of dissociation can be observed in the infrared predissociation spectrum at a particular rotational energy level in the νDD manifold