17 research outputs found
Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
Understanding the use of Smart Working in Public Administration: the experience of the Presidency of the Council of Ministers
While there is no consensus in terms of what “smart government” includes and how it is related to emergent technologies and innovation in the public sector, in this paper smart working (SW) is regarded as one of the most important initiatives for building smart government. In the Italian public sector—according to the Law n. 81/2017—SW has emerged as a “new” way to define what is considered as an innovative approach to work organisation and human resource management. Analysing the Presidency of the Council of Ministers case study the paper aims to investigate to answer to the following questions: (i) to what extent is the interface between organisational model for working and new technology contextually bound? (ii) what are the combination of the different elements affecting the configuration of SW? (iii) what are the outcomes of SW likely to be for smar-workers, organisations and society
ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish
Recognizing and treating secondary osteoporosis
Osteoporosis, through its association with fragility fracture, is a major public health problem, costing an estimated $34.8 billion worldwide per annum. With projected demographic changes, the burden looks set to grow. Therefore, the prevention of osteoporosis, as well as its identification and treatment once established, are becoming increasingly important. Osteoporosis is secondary when a drug, disease or deficiency is the underlying cause. Glucocorticoids, hypogonadism, alcohol abuse and malnutrition are among the most frequently recognized causes of secondary osteoporosis but the list of implicated diseases and drugs is growing and some of the more recently recognized associations, such as those with haematological conditions and acid-suppressing medications, are less well publicized. In some cases, advancement in treatment of the primary disease has led to people living long enough to develop secondary osteoporosis; for example, successful treatment for breast and prostate malignancies by hormonal manipulation, improved survival in HIV with the advent of anti-retroviral therapies, and improved treatment for cystic fibrosis. This Review emphasizes the importance of secondary osteoporosis, discusses familiar and less well-known causes and what is known of their mechanisms, provides guidance as to the pragmatic identification of secondary osteoporosis and summarizes treatment options, where available.<br/