8 research outputs found
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Clinical Neuro-Protection Trials in Severe Traumatic Brain Injury: Lessons from Previous Studies
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Does continuous measurement of brain tissue temperature reflect cerebral blood flow in the severely head injured patients?
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Reducing Hemoglobin Oxygen Affinity Does Not Increase Hydroxyl Radicals After Acute Subdural Hematoma in the Rat
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Correlations Between Brain Tissue Oxygen Tension, Carbon Dioxide Tension, pH, and Cerebral Blood Flow—A Better Way of Monitoring The Severely Injured Brain?
Background
The ideal method for monitoring the acutely injured brain would measure substrate delivery and brain function continuously, quantitatively, and sensitively. We have tested the hypothesis that brain pO
2, pCO
2, and pH, which can now be measured continuously using a single sensor, are valid indicators of regional cerebral blood flow (CBF) and oxidative metabolism, by measuring its product, brain pCO
2.
Methods
Twenty-five patients (Glasgow Coma Score ≤ 8) were studied. A Clark electrode, combined with a fiber optic system (Paratrend 7, Biomedical Sensors, Malvern, PA) was used to measure intraparenchymal brain pO
2, pCO
2, and pH. Data were averaged over a 1-h period before and after CBF studies. Regional CBF was measured around the probe, using stable xenon computed tomography. Regression analyses and Spearman Rank tests were used for data analysis.
Results
Regional CBF and mean brain pO
2 were strongly correlated (r = 0.74,
p = 0.0001). CBF values < 18 mL/100 g/min were all accompanied by brain pO
2 ≤ 26 mm Hg. The four patients with a brain pO
2 < 18 mm Hg died. Brain pCO
2 and pH, however, were not correlated with CBF (r = 0.36,
p = 0.24 and r = 0.30,
p = 0.43, respectively).
Conclusions
Until recently, substrate supply to the severely injured brain could only be intermittently estimated by measuring CBF. The excellent intra-regional correlation between CBF and brain pO
2, suggests that this method does allow continuous monitoring of true substrate delivery, and offers the prospect that measures to increase O
2 delivery (e.g., increasing CBF, CPP, perfluorocarbons etc.) can be reliably tested by brain pO
2 monitoring
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Glutamate, lactate and glucose — Ischemic thresholds determined according to cerebral blood flow measurements in severe human head injury
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