91 research outputs found
Correlation between blood mercury levels in mothers and newborns in Itaituba, Pará State, Brazil
Influence of the hydrolysis and condensation time on the preparation of hybrid materials
Comparative study of human exposure to mercury in riverside communities in the Amazon region
Longitudinal assessment of mercury exposure in schoolchildren in an urban area of the Brazilian Amazon
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to similar to 370,000 women, we identify 389 independent signals (P <5 x 10(-8)) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain similar to 7.4% of the population variance in age at menarche, corresponding to similar to 25% of the estimated heritability. We implicate similar to 250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility
Para além dos cacos: a Arqueologia Histórica a partir de três superartefatos (estudo de caso de três igrejas jesuíticas)
A relação das enciclopédias com os índices e a Web semântica: linhas de força para a organização e significação na pós-modernidade
Da experiência da fala de sujeitos usuários na clínica psicológica às suas possíveis repercussões
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