28 research outputs found
CHANGES IN CLINICAL-FEATURES OF CELIAC-DISEASE IN ADULTS IN EDINBURGH AND THE LOTHIANS 1960-79
Racial Discrimination Is Associated with a Measure of Red Blood Cell Oxidative Stress: A Potential Pathway for Racial Health Disparities
Abstract available at publisher's web site
Monitoring performance of sites within multicentre randomised trials: a systematic review of performance metrics
Corn oil and beef tallow elicit different postprandial responses in triglycerides and cholesterol, but similar changes in constituents of high-density lipoprotein.
Aging-related changes in the calorimetric profile of red blood cells from women with miscarriages
Erythrocyte’s aging in microgravity highlights how environmental stimuli shape metabolism and morphology
A mitochondrial pathway for biosynthesis of lipid mediators
The central role of mitochondria in metabolic pathways and in cell death mechanisms requires sophisticated signaling systems. Essential in this signaling process is an array of lipid mediators derived from polyunsaturated fatty acids. However, the molecular machinery for the production of oxygenated polyunsaturated fatty acids is localized in the cytosol and their biosynthesis has not been identified in mitochondria. Here we report that a range of diversified polyunsaturated molecular species derived from a mitochondria-specific phospholipid, cardiolipin, are oxidized by the intermembrane space hemoprotein, cytochrome c. We show that an assortment of oxygenated cardiolipin species undergoes phospholipase A2-catalyzed hydrolysis thus generating multiple oxygenated fatty acids, including well known lipid mediators. This represents a new biosynthetic pathway for lipid mediators. We demonstrate that this pathway including oxidation of polyunsaturated cardiolipins and accumulation of their hydrolysis products – oxygenated linoleic, arachidonic acids and monolyso-cardiolipins – is activated in vivo after acute tissue injury