Fetal macrosomia as an important indicator of fetal malformation syndrome: ultrasonic findings of two cases

Two extraordinary cases of fetal macrosomia are presented. It is discussed that extreme fetal growth should raise the suspicion of a malformation syndrome and deserves thorough antenatal ultrasonographic examination

roken en zwangerschap

Prospectief onderzoek onder gezonde nulliparae naar de gevolgen van roken in de zwangerschap voor moeder en kin

Effects of maternal smoking on neonatal morbidity

In this paper a prospective study of the association between maternal smoking and neonatal morbidity variables is presented. Caucasian nulliparous women (n = 115)were studied throughout pregnancy, childbirth and puerperal period. Birthweight(-centiles), Apgar scores, mode of delivery, umbilical arterial and venous blood gas analyses, admission incidence to the neonatal ward and neurological examnination according to Prechtl were considered to be representatives for the starting condition of the newborns. The babies of smokers were statistically significantly at a disadvantage compared to babies of non-smokers for birthweight(-centiles), pH of the umbilical vein (medians): smokers 7.29, non-smokers 7.30) and the score of the neurological examnination (medians: smokers 57, non-smokers 58)

The sonographic imaging of fetal adrenal neuroblastoma; a case report

A case of fetal adrenal neuroblastoma is reported, the sonographic imaging and the antenatal diagnosis of adrenal neuroblastoma is considere

Assessment of tobacco-exposure during pregnancy; behavioural and biochemical changes

Smoking-behavior during pregnancy and the reliability of an interview were prospectively investigated. The tobacco-exposure was assessed a) by an intake interview b) by a smoking diary and c) by maternal thiocyanate and carboxy-hemoglobin concentrations. Of the 115 nulliparous women, 66 smoked (57.4%). Seventeen women (25.8%) quit and 39 women (59.1%) reduced smoking. Directly after intake, in the first week of the diary, significantly more cigarettes were smoked than stated during the intake interview. According to the diaries, the number of cigarettes increased during the first half of pregnancy. In the 24th week significantly more cigarettes were smoked than in the first week after intake. Also a significant increase of thiocyanate between the measurements at intake and in the 24th of amenorrhea was found. The maternal carboxy-hemoglobin levels did not significantly change during pregnancy. Investigators should be aware of changes in smoking behavior during pregnancy and the potential bias of self reported smoking behavior at the beginning of pregnancy. The tobacco-exposure should be assessed (anamnestic or biochemical) several times during pregnancy, anyway it should include the second half of pregnancy