Composition consisting of a dendrimer and an active substance

The invention relates to a composition consisting of a dendrimer provided with blocking agents and an active substance occluded in the dendrimer. According to the invention a blocking agent is a compound which is sterically of sufficient size, which readily enters into a chemical bond with the terminal groups of a dendrimer and which can also be split off from the dendrimer or be modified without thereby affecting the chemical structure of the dendrimer and the active substance. The blocking agent can be provided with protective groups. Such conjugates have the advantage that the time at which the releasing of the active substance starts, can be controlled. The invention also relates to a process for the preparation of such a composition and to a process for the controlled release of the active substance

Dendrimer and an active substance occluded in the dendrimer : a process for the preparation thereof and a process for releasing the active substance

The invention relates to a dendrimer composition in which an effective number of the terminal functionalities are provided with blocking agents, and at least one active substance species is occluded in the dendrimer. A blocking agent is a sufficiently sterically sized compound which readily enters into a chemical bond with a terminal group of a dendrimer but which can also be split off from the dendrimer or can be modified without affecting the chemical structure of the dendrimer and the occluded active substance. The blocking agent can also be provided with a protecting group. The time and duration over which an active substance is released can be controlled. The invention also relates to a process for the preparation of such a composition and to a process for the controlled release of the active substance

How do urban parks, neighborhood open spaces, and private gardens relate to individuals’ subjective well-being:Results of a structural equation model

As urban areas become more densely populated worldwide, the allocation of limited urban green infrastructure to promote well-being among users is becoming increasingly challenging. This study aims to understand the relationships of three types of urban green infrastructure (urban parks, neighborhood green open spaces and private gardens) with subjective well-being (SWB). We construct a structural equation model to examine these relationships in an integrated fashion. We consider both direct and indirect effects of green spaces on SWB. Data were collected through an online questionnaire involving a sample of 322 individuals in the Netherlands. Results indicate that the direct relationship between neighborhood green satisfaction and SWB is positive and stronger than the relationship between satisfaction with urban parks and SWB. Private garden size has an indirect positive effect on SWB mediated by neighborhood green satisfaction. Interestingly, an individual with higher satisfaction with green tends to have higher SWB independently of the frequency of using the green space. Overall, our method and results bring new insights to optimize urban green space planning to enhance users’ SWB.</p

How Do Socio-Demographic Characteristics Affect Users’ Perception of Place Quality at Station Areas? Evidence from Amsterdam, The Netherlands

Incorporating users’ experiences in transport hub (re)development has become paramount, especially in the case of (high-speed) railway stations located in central urban locations. Designing “quality” according to users’ perspectives requires that we rethink about the dimensions to be prioritized, but also consider the variegated perspectives of users. Drawing on data from a survey of 452 users of the Amsterdam Central station area in the Netherlands, the relative importance of three value perspectives (node, place, and experience) on place quality were assessed through exploratory factor analysis. Seven quality factors were identified. Furthermore, relationships between socio-demographic characteristics and quality perceptions were simultaneously analyzed using a path analysis. The outcome showed that age and gender play a key role in explaining different quality perceptions. Senior citizens attach a higher importance to basic needs and safety and advanced services, while women also find wayfinding important. Moreover, education and visiting purpose influence other aspects of place quality perception, such as shopping or transfer. These findings provide a better understanding of place quality considerations in railway station areas in general and can serve as guidelines for the improvement of Amsterdam Central station, in particular

Collective self-build for senior friendly communities. Studying the effects on social cohesion, social satisfaction and loneliness

Neighbourhood social cohesion is important for the health and well-being of the ageing population. It is therefore crucial to study how we can create neighbourhoods with high levels of neighbourhood social cohesion where senior citizens can age in place. We test the hypotheses that collective self-build is positively related to social cohesion and (directly and indirectly) to social satisfaction and lower levels of loneliness. The study is based on survey data from 326 respondents of 50 years and over living in 25 collective self-build development projects and 19 conventionally developed housing projects in the Netherlands. The results of a structural equation model (SEM) reveal that collective self-build is directly related to neighbourhood social cohesion and lower feelings of social loneliness. We find an indirect effect on social satisfaction. These positive relationships hold while controlling for personal and household characteristics. This quantitative study adds scientific knowledge on the collective self-build development method and its relation to social cohesion, loneliness and satisfaction

Dendritic macromolecule and the preparation thereof

The invention relates to a dendritic macromolecule comprising a core and branches emanating from the core wherein the branches are based on vinyl cyanide and/or fumaryl dinatrile units. The invention also relates to processes for preparing these dendritic macromolecules. The dendritic macromolecules according to the invention are not sensitive to degradation through hydrolysis reactions and are also very stable at a high temperature. The processes are very suitable for large scale production of the dendritic macromolecules without requiring purification of reaction intermediates