CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF INTERFERON ALPHA_2 AS A PART OF COMPLEX THERAPY OF CHILDREN, SUFFERING FROM THE LINGERING RECURRENT FORMS OF PSEUDOTUBERCULOSIS

The researchers have examined 45 children aged between 3 and 14, suffering from the lingering recurrent forms of pseudotuberculosis. 25 children (55,6%) received some conventional therapy, whereas 20 patients (44,3%) used interferon alpha_2. The practice demonstrated that the introduction of interferon alpha 2 into the complex therapy of children, suffering from pseudotuberculosis, led to a considerable decrease in the intensity and duration of the main pseudotuberculosis syndromes (intoxication, fever, hepatomegaly, exanthema, arthralgia, gastroenteritis). Clinical efficiency of interferon alpha 2 was con firmed by the positive dynamics of immunological indices. The researchers have uncovered a clear anti recurrent therapy effect: relapses were noted among 5% of patients if compared with 15% within a group of children, who received the conventional therapy.Key words: pseudotuberculosis, children, interferon Alpha 2

CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF INTERFERON ALPHA_2 AS A PART OF COMPLEX THERAPY OF CHILDREN, SUFFERING FROM THE LINGERING RECURRENT FORMS OF PSEUDOTUBERCULOSIS

The researchers have examined 45 children aged between 3 and 14, suffering from the lingering recurrent forms of pseudotuberculosis. 25 children (55,6%) received some conventional therapy, whereas 20 patients (44,3%) used interferon alpha_2. The practice demonstrated that the introduction of interferon alpha 2 into the complex therapy of children, suffering from pseudotuberculosis, led to a considerable decrease in the intensity and duration of the main pseudotuberculosis syndromes (intoxication, fever, hepatomegaly, exanthema, arthralgia, gastroenteritis). Clinical efficiency of interferon alpha 2 was con firmed by the positive dynamics of immunological indices. The researchers have uncovered a clear anti recurrent therapy effect: relapses were noted among 5% of patients if compared with 15% within a group of children, who received the conventional therapy.Key words: pseudotuberculosis, children, interferon Alpha 2