1 research outputs found
Evaluation of the nephrons number in children with congenital pathology of the cardiovascular system
Background. The purpose of the study is to determine the dynamics of growth
and differentiation of cortical and perimedullary nephrons in children with pathology of the
cardiovascular system. Materials and methods. We researched the histological material of
the kidneys painted by hematoxylin-eosin and obtained from postmortem, from pediatric
patients with congenital heart disease (open foramen ovale, ventricular septal defect and
without pathology this patients has age range from 0 to 12 months) patients divided into
three age groups (0β2, 4β6, 10β12 months). During microscopy, the number of nephrons in
the field of view in the subcortical zone and separately in the perimedullary zone of the cortical
substance was counted, the data obtained were subjected to statistical processing. Results.
In patients without pathology of the cardiovascular system, the differentiation of subcortical
nephrons during the first year of life occurs linearly. There is a clear trend towards
a decrease in the number of nephrons per unit area with age. The development of pericerebral
nephrons in the same group up to 6 months is similar, but by the age of 10β12 months,
the number of bodies of perimedullary nephrons per conventional unit of area increases to
values determined at 2 months of age. Conclusions. In patients with pathology of the cardiovascular
system, the dynamics of differentiation of nephrons in the subcapsular zone differs
from those found in the first group and repeats the dynamics of differentiation of
perimedullary nephrons. The presence of congenital malformations of the cardiovascular
system during the first year of a child's life leads to changes in the differentiation of the renal
parenchyma. In children without pathology of the cardiovascular system, there is a decrease
in the number of nephrons per conventional unit of area during the first year of life.
Changes in the differentiation of nephrons in the subcapsular zone of the kidneys in the
presence of congenital malformations of the cardiovascular system can become one of the
pathogenetic stages in the development of arterial hypertension