Quality in Statistical Systems: The Challenge for Puerto Rico

In Puerto Rico, confidence in public data has been deeply compromised. Examination of extant island data demonstrates shortcomings in measuring basic variables that are now crucial in the international context. Demands from researchers, and from governmental and private constituents resulted in Law 209 of August 28, 2003 (The Law).  The Law created the Statistics Institute of Puerto Rico (The Institute) to induce significant changes in statistical production processes and to coordinate the creation of a reliable statistical system for public data on the island.  As part of its mandate, The Institute is implementing a quality assurance process that aims to guarantee rights of all constituents to opportune and reliable information.  This article summarizes and interprets ongoing initiatives taken by The Institute to meet quality assurance objectives of The Law. It also intends to contribute to broader international conversations on statistical quality and its central role in regaining people’s trust in decision making processes.

Bioactivity of Essential Oils against Multi-Drug Resistant Bacteria from Clinical Samples

Spread of antibiotic resistant bacteria is most frequently seen in clinics leading to prolonged hospitalization, treatment failures and often high mortality rates. This has necessitated the search for alternative agents that may have antibacterial effect such as essential oils. These are complex natural mixtures isolated by steam distillation and have been traditionally used for treatment of acne inflammation. Aspirin, digoxin, morphine are few examples of drugs discovered from plant extracts.Objectives: To determine the bioactivity of essential oils against multidrug resistant bacteria from clinical samples. Methods: Nine clinical isolates were isolated from patients without duplicates. Bacterial isolates were identified and characterized by use of morphological, cultural, biochemical and antibiotic sensitivity patterns. Results: All nine different clinical isolates were multi drug resistant with 100%, 50% and 30% of isolate resistant to erythromycin, cloxacillin, ampicillin, neomycin, gentamycin and rifampicin respectively. Essential oils showed antibacterial activity against all 9 clinical isolates. Conclusion: Essential oils have proved to have antimicrobial potential against the multidrug resistant bacteria and this has led to their use in therapeutic treatment. High polar solvents are more effective. Keywords: Wound isolates, multidrug resistant, essential oils, antibiotic

On a coordinate independent description of string worldsheet theory

We study worldsheet conformal invariance for bosonic string propagating in a curved background using the hamiltonian formalism. In order to formulate the problem in a background independent manner we first rewrite the worldsheet theory in a language where it describes a single particle moving in an infinite-dimensional curved spacetime. This language is developed at a formal level without regularizing the infinite-dimensional traces. Then we adopt DeWitt's (Phys.Rev.85:653-661,1952) coordinate independent formulation of quantum mechanics in the present context. Given the expressions for the classical Virasoro generators, this procedure enables us to define the coordinate invariant quantum analogues which we call DeWitt-Virasoro generators. This framework also enables us to calculate the invariant matrix elements of an arbitrary operator constructed out of the DeWitt-Virasoro generators between two arbitrary scalar states. Using these tools we further calculate the DeWitt-Virasoro algebra in spin-zero representation. The result is given by the Witt algebra with additional anomalous terms that vanish for Ricci-flat backgrounds. Further analysis need to be performed in order to precisely relate this with the beta function computation of Friedan and others. Finally, we explain how this analysis improves the understanding of showing conformal invariance for certain pp-wave that has been recently discussed using hamiltonian framework.Comment: 32 pages, some reorganization for more elaborate explanation, no change in conclusio

Multiresolution analysis of active region magnetic structure and its correlation with the Mt. Wilson classification and flaring activity

Two different multi-resolution analyses are used to decompose the structure of active region magnetic flux into concentrations of different size scales. Lines separating these opposite polarity regions of flux at each size scale are found. These lines are used as a mask on a map of the magnetic field gradient to sample the local gradient between opposite polarity regions of given scale sizes. It is shown that the maximum, average and standard deviation of the magnetic flux gradient for alpha, beta, beta-gamma and beta-gamma-delta active regions increase in the order listed, and that the order is maintained over all length-scales. This study demonstrates that, on average, the Mt. Wilson classification encodes the notion of activity over all length-scales in the active region, and not just those length-scales at which the strongest flux gradients are found. Further, it is also shown that the average gradients in the field, and the average length-scale at which they occur, also increase in the same order. Finally, there are significant differences in the gradient distribution, between flaring and non-flaring active regions, which are maintained over all length-scales. It is also shown that the average gradient content of active regions that have large flares (GOES class 'M' and above) is larger than that for active regions containing flares of all flare sizes; this difference is also maintained at all length-scales.Comment: Accepted for publication in Solar Physic

RetroSpective cohort stUdy of PD-L1 expression in REcurrent and/or MEtastatic squamous cell carcinoma of the head and neck (SUPREME-HN)

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Observing Supermassive Black Holes across cosmic time: from phenomenology to physics

In the last decade, a combination of high sensitivity, high spatial resolution observations and of coordinated multi-wavelength surveys has revolutionized our view of extra-galactic black hole (BH) astrophysics. We now know that supermassive black holes reside in the nuclei of almost every galaxy, grow over cosmological times by accreting matter, interact and merge with each other, and in the process liberate enormous amounts of energy that influence dramatically the evolution of the surrounding gas and stars, providing a powerful self-regulatory mechanism for galaxy formation. The different energetic phenomena associated to growing black holes and Active Galactic Nuclei (AGN), their cosmological evolution and the observational techniques used to unveil them, are the subject of this chapter. In particular, I will focus my attention on the connection between the theory of high-energy astrophysical processes giving rise to the observed emission in AGN, the observable imprints they leave at different wavelengths, and the methods used to uncover them in a statistically robust way. I will show how such a combined effort of theorists and observers have led us to unveil most of the SMBH growth over a large fraction of the age of the Universe, but that nagging uncertainties remain, preventing us from fully understating the exact role of black holes in the complex process of galaxy and large-scale structure formation, assembly and evolution.Comment: 46 pages, 21 figures. This review article appears as a chapter in the book: "Astrophysical Black Holes", Haardt, F., Gorini, V., Moschella, U and Treves A. (Eds), 2015, Springer International Publishing AG, Cha

Observation of exclusive DVCS in polarized electron beam asymmetry measurements

We report the first results of the beam spin asymmetry measured in the reaction e + p -> e + p + gamma at a beam energy of 4.25 GeV. A large asymmetry with a sin(phi) modulation is observed, as predicted for the interference term of Deeply Virtual Compton Scattering and the Bethe-Heitler process. The amplitude of this modulation is alpha = 0.202 +/- 0.028. In leading-order and leading-twist pQCD, the alpha is directly proportional to the imaginary part of the DVCS amplitude.Comment: 6 pages, 5 figure

A Bayesian analysis of pentaquark signals from CLAS data

We examine the results of two measurements by the CLAS collaboration, one of which claimed evidence for a $\Theta^{+}$ pentaquark, whilst the other found no such evidence. The unique feature of these two experiments was that they were performed with the same experimental setup. Using a Bayesian analysis we find that the results of the two experiments are in fact compatible with each other, but that the first measurement did not contain sufficient information to determine unambiguously the existence of a $\Theta^{+}$. Further, we suggest a means by which the existence of a new candidate particle can be tested in a rigorous manner.Comment: 5 pages, 3 figure

Electron Scattering From High-Momentum Neutrons in Deuterium

We report results from an experiment measuring the semi-inclusive reaction $d(e,e'p_s)$ where the proton $p_s$ is moving at a large angle relative to the momentum transfer. If we assume that the proton was a spectator to the reaction taking place on the neutron in deuterium, the initial state of that neutron can be inferred. This method, known as spectator tagging, can be used to study electron scattering from high-momentum (off-shell) neutrons in deuterium. The data were taken with a 5.765 GeV electron beam on a deuterium target in Jefferson Laboratory's Hall B, using the CLAS detector. A reduced cross section was extracted for different values of final-state missing mass $W^{*}$, backward proton momentum $\vec{p}_{s}$ and momentum transfer $Q^{2}$. The data are compared to a simple PWIA spectator model. A strong enhancement in the data observed at transverse kinematics is not reproduced by the PWIA model. This enhancement can likely be associated with the contribution of final state interactions (FSI) that were not incorporated into the model. A ``bound neutron structure function'' $F_{2n}^{eff}$ was extracted as a function of $W^{*}$ and the scaling variable $x^{*}$ at extreme backward kinematics, where effects of FSI appear to be smaller. For $p_{s}>400$ MeV/c, where the neutron is far off-shell, the model overestimates the value of $F_{2n}^{eff}$ in the region of $x^{*}$ between 0.25 and 0.6. A modification of the bound neutron structure function is one of possible effects that can cause the observed deviation.Comment: 33 pages RevTeX, 9 figures, to be submitted to Phys. Rev. C. Fixed 1 Referenc