Measurement of CP observables in B± → D(⁎)K± and B± → D(⁎)π± decays

Measurements of CP observables in B ± →D (⁎) K ± and B ± →D (⁎) π ± decays are presented, where D (⁎) indicates a neutral D or D ⁎ meson that is an admixture of D (⁎)0 and D¯ (⁎)0 states. Decays of the D ⁎ meson to the Dπ 0 and Dγ final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± π ∓ , K + K − and π + π − final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb −1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± →D ⁎ K ± and B ± →D ⁎ π ± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± →DK ± and B ± →Dπ ± decays is an update of previous LHCb measurements. The B ± →DK ± results are the most precise to date

Measurement of the muon flux from 400 GeV/c protons interacting in a thick molybdenum/tungsten target

The SHiP experiment is proposed to search for very weakly interacting particles beyond the Standard Model which are produced in a 400 GeV/c proton beam dump at the CERN SPS. About 1011 muons per spill will be produced in the dump. To design the experiment such that the muon-induced background is minimized, a precise knowledge of the muon spectrum is required. To validate the muon flux generated by our Pythia and GEANT4 based Monte Carlo simulation (FairShip), we have measured the muon flux emanating from a SHiP-like target at the SPS. This target, consisting of 13 interaction lengths of slabs of molybdenum and tungsten, followed by a 2.4 m iron hadron absorber was placed in the H4 400 GeV/c proton beam line. To identify muons and to measure the momentum spectrum, a spectrometer instrumented with drift tubes and a muon tagger were used. During a 3-week period a dataset for analysis corresponding to (3.27±0.07) × 1011 protons on target was recorded. This amounts to approximatively 1% of a SHiP spill

Track reconstruction and matching between emulsion and silicon pixel detectors for the SHiP-charm experiment

In July 2018 an optimization run for the proposed charm cross section measurement for SHiP was performed at the CERN SPS. A heavy, moving target instrumented with nuclear emulsion films followed by a silicon pixel tracker was installed in front of the Goliath magnet at the H4 proton beam-line. Behind the magnet, scintillating-fibre, drift-tube and RPC detectors were placed. The purpose of this run was to validate the measurement's feasibility, to develop the required analysis tools and fine-tune the detector layout. In this paper, we present the track reconstruction in the pixel tracker and the track matching with the moving emulsion detector. The pixel detector performed as expected and it is shown that, after proper alignment, a vertex matching rate of 87% is achieved

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

First observation of forward Z→bbˉZ \rightarrow b \bar{b} production in pppp collisions at s=8\sqrt{s}=8 TeV

The decay Z→bb¯ is reconstructed in pp collision data, corresponding to 2 fb −1 of integrated luminosity, collected by the LHCb experiment at a centre-of-mass energy of s=8 TeV. The product of the Z production cross-section and the Z→bb¯ branching fraction is measured for candidates in the fiducial region defined by two particle-level b -quark jets with pseudorapidities in the range 2.220 GeV and dijet invariant mass in the range 4520$GeV and dijet invariant mass in the range$45 < m_{jj} < 165$GeV. From a signal yield of$5462 \pm 763$$Z \rightarrow b \bar{b}$events, where the uncertainty is statistical, a production cross-section times branching fraction of$332 \pm 46 \pm 59$pb is obtained, where the first uncertainty is statistical and the second systematic. The measured significance of the signal yield is 6.0 standard deviations. This measurement represents the first observation of the$Z \rightarrow b \bar{b}$production in the forward region of$pp$ collisions

CLINICAL STRUCTURE AND REVELATION OF TUBERCULOSIS WITHIN TENSE EPIDEMICAL SITUATION IN MOSCOW

The article analyzes dynamics of incidence of tuberculosis in children 0–14 years old in Moscow (1993–2000 years). The role of antituberculosis healthcare services in revelation of infected children increases while the participation of general healthcare services in this process becomes low. The structure of tuberculosis in children according to clinical forms and revelation methods is studied. Changes in group structure of revealed patients with relative stabilization of children’s morbidity come due to increase of secondary tuberculosis rate and late diagnostics of out-of-pulmonary disease.Key words: children, tuberculosis, morbidity, diagnostics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 76–79)</strong

CLINICAL STRUCTURE AND REVELATION OF TUBERCULOSIS WITHIN TENSE EPIDEMICAL SITUATION IN MOSCOW

The article analyzes dynamics of incidence of tuberculosis in children 0–14 years old in Moscow (1993–2000 years). The role of antituberculosis healthcare services in revelation of infected children increases while the participation of general healthcare services in this process becomes low. The structure of tuberculosis in children according to clinical forms and revelation methods is studied. Changes in group structure of revealed patients with relative stabilization of children’s morbidity come due to increase of secondary tuberculosis rate and late diagnostics of out-of-pulmonary disease.Key words: children, tuberculosis, morbidity, diagnostics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 76–79

Determination of the optimal configuration of the molecular system «manganese silicate nanoparticles-an essential amino acid»

In this study, the optimal configuration of the molecular system «manganese silicate nanoparticles - essential amino acid» was determined using quantum chemical simulation. To begin with, quantum chemical simulation of individual molecules of manganese silicate and essential amino acids was carried out, after which molecular systems «manganese silicate nanoparticles - essential amino acids» were modeled, in which an oxygen atom attached to silicon atom in manganese silicate was combined with an ionized amino group of amino acids. As a result, it was found that the molecular systems «manganese silicate nanoparticles - essential amino acids» are energetically advantageous and chemically stable. Based on the data obtained, it can be concluded that the optimal configuration of these molecular systems is the interaction of manganese silicate with lysine through the ionized α-amino group of lysine. This molecular system has the highest values of the difference in total energy (ΔE = 73.268 kcal/mol) and chemical hardness (η = 0.144 eV), which are indicators of energy benefits and chemical stability of molecular system. After mixing manganese acetate, L-lysine and sodium silicate, manganese silicate nanoparticles stabilized with L-lysine were obtained

Hydride donating abilities of the tetracoordinated boron hydrides

The hydride donating ability (HDA), determined as Gibbs free energy (ΔG°H −) for the reaction of H− dissociation, was assessed via the DFT/M06/6-311++G (d,p) calculations for 90 tetracoordinated borohydrides Li [L3B-H] taking into account the solvent effects via the optimization in MeCN and CH2Cl2 under SMD model. Obtained this way, the HDAMeCN values vary from 118.2 to 13.4 kcal/mol and correlate well with the Lewis acidity parameters (AN, HA and FA) of parent trigonal boranes (L3B). These data show numerically how the variation of the substituents at the boron atom allows the fine-tuning the B–H bond reactivity (reduction power) in the reactions involving hydride transfer as well as the selectivity of the reduction processes. The analysis of the data obtained shows that by varying the number of substituents and their nature, it is possible not only to change the properties of neutral trisubstituted boranes from highly electrophilic (represented by halogenide- and pseudohalogenide-boranes) to highly nucleophilic (exemplified by alkoxy-an amidoboranes), but also to repolarize the boron-bound hydrogen and make the proton transfer process more favourable than the hydride transfer. © 2018 Elsevier B.V