Gravitationally lensed QSOs in the ISSIS/WSO-UV era

Gravitationally lensed QSOs (GLQs) at redshift z = 1-2 play a key role in understanding the cosmic evolution of the innermost parts of active galaxies (black holes, accretion disks, coronas and internal jets), as well as the structure of galaxies at intermediate redshifts. With respect to studies of normal QSOs, GLQ programmes have several advantages. For example, a monitoring of GLQs may lead to unambiguous detections of intrinsic and extrinsic variations. Both kinds of variations can be used to discuss central engines in distant QSOs, and mass distributions and compositions of lensing galaxies. In this context, UV data are of particular interest, since they correspond to emissions from the immediate surroundings of the supermassive black hole. We describe some observation strategies to analyse optically bright GLQs at z of about 1.5, using ISSIS (CfS) on board World Space Observatory-Ultraviolet.Comment: 7 pages, 4 figures, Accepted for publication in Astrophysics & Space Scienc

Enthesopathy in spondyloarthritis: The literature review

The article presents data on epidemiology, pathogenesis, clinical manifestations, diagnosis and therapy of enthesopathy in spondyloarthritis. The approaches to assessment of this pathology are examined and detailed, modern clinical and ultrasound indices are given. The features of enthesopathy in diseases that included in the group of spondyloarthridies are described

Alterations of the Purinergic Regulation in Mesenteric Arteries of Pannexin-1-Knockout Mice

Pannexin 1 (Panx1) forms plasma membrane channels that release ATP, an important vascular tone regulator. However, despite the abundant expression of Panx1 in the vascular system, its effects on smooth muscle contraction are not evident in all arteries. In this study, we tested the hypothesis that the functional consequences of Panx1 deficiency can be masked by the augmented action of ATP secreted in a Panx1-independent way. Experiments were performed on small mesenteric arteries obtained from Panx1-knockout (Panx1–/–) and C57Bl/6 (Panx1+/+) male mice using wire myography of endothelium-denuded arterial preparations and reverse-transcription quantitative PCR techniques. Arterial contractile responses to phenylephrine did not differ in two experimental groups. Ecto-ATPase inhibitor ARL67156 (100 μM) potentiated the responses to phenylephrine in Panx1+/+ but not in Panx1–/–, while ARL67156 did not affect the contractile responses to the thromboxane A2 receptor agonist in any of the two groups. Contractile responses to exogenous ATP (10 μM) were smaller in Panx1+/+ than in Panx1–/– mice. By contrast, NTPDase1 mRNA content was higher in Panx1+/+ than in Panx1–/– mice. These results suggest that ATP released from smooth muscle cells through Panx1 channels can potentiate contractile responses of murine mesenteric arteries upon activation of α1-adrenoceptors. In Panx1–/– mice an increased arterial ATP sensitivity and diminished NTPDase1 activity may augment the contractile effects of Panx1-independent ATP