A Geometric Approach to Massive p-form Duality

Massive theories of abelian p-forms are quantized in a generalized path-representation that leads to a description of the phase space in terms of a pair of dual non-local operators analogous to the Wilson Loop and the 't Hooft disorder operators. Special atention is devoted to the study of the duality between the Topologically Massive and the Self-Dual models in 2+1 dimensions. It is shown that these models share a geometric representation in which just one non local operator suffices to describe the observables.Comment: 26 pages, LaTeX. The discussion about the equivalence between the Proca model and two seldual models, with opposite spins, was eliminated. Typos correcte

BF models, Duality and Bosonization on higher genus surfaces

The generating functional of two dimensional $BF$ field theories coupled to fermionic fields and conserved currents is computed in the general case when the base manifold is a genus g compact Riemann surface. The lagrangian density $L=dB{\wedge}A$ is written in terms of a globally defined 1-form $A$ and a multi-valued scalar field $B$. Consistency conditions on the periods of $dB$ have to be imposed. It is shown that there exist a non-trivial dependence of the generating functional on the topological restrictions imposed to $B$. In particular if the periods of the $B$ field are constrained to take values $4\pi n$, with $n$ any integer, then the partition function is independent of the chosen spin structure and may be written as a sum over all the spin structures associated to the fermions even when one started with a fixed spin structure. These results are then applied to the functional bosonization of fermionic fields on higher genus surfaces. A bosonized form of the partition function which takes care of the chosen spin structure is obtainedComment: 17 page

Bringing Japanese Continuous Improvement Approaches to U.S. Manufacturing: The Roles of Process Orientation and Communications *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71419/1/j.1540-5915.1995.tb01442.x.pd

The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease