Determination of design and operation parameters influence of screw type pelletizer on crumbling and temperature of soybean chaff pellets

This article presents the study of significant factors influence on the pelletizing process of soybean chaff. The aim of the research was to determine the operating modes of the screw providing chaff soybean pellets output with a crumbling of not more than 12% at the optimum pelletizing temperature of 70 — 80°C. To study the significant factors influence - such as the flight screw step, the screw rotation speed, chaff moisture - on the process of soybean chaff pelletizing, as well as the optimal values variation of these factors, search experiments were conducted on the screw type laboratory pelleting press XP-3. Regression equations were calculated as a result of the studies, which are adequately describing the influence of significant factors on the output of proper quality pellets; this will allow to develop the technology for chaff compacting in the process of stationary processing of the grain and soybean heap, which allows to reduce the costs of transportation and storage of soybean chaff

Comparative analysis of dalargin pharmaceutical substance identification methods

Introduction. The quality control of a medicinal product needs to be systematically improved in connection with a continuous increase in the requirements for the quality of medicines. When assessing the quality of substances and drugs, the most important indicators are authenticity, the content of the main substance and impurities. This makes it relevant to introduce modern physical and chemical methods of analysis into industrial practice in determining parameters such as authenticity, the content of the main substance and impurities. The choice and applicability of a particular method is possible only when conducting comparative studies on the application of a particular method to solve this problem. The method should preferably be recommended by the Pharmacopoeia, give unambiguous results, and the analysis should not be expensive and affordable. The methods chosen for comparative analysis are well known, but it should be noted that in recent years, instrument-making companies have significantly improved their instrument base and expanded their capabilities. Therefore, one of the objectives of this article is to demonstrate the capabilities of the selected methods for solving the problems of drug quality control using dalargin as an example. Aim. To develop methods for determining the authenticity of the active substance in a substance – Dalargin powder using NMR spectroscopy, IR spectrometry, and Mass spectroscopy. Conduct a comparative analysis of the applicability of the selected methods to solve the problem. Materials and methods. To determine the authenticity of the substance – the powder «Dalargin» used the methods of mass spectrometry,13 C NMR and1H NMR spectrometry and IR spectrometry. Results and discussions. Methods have been developed for determining the authenticity of the test substance by NMR, IR, and mass spectrometry. A comparative study of the possibilities of the selected methods in solving the problem. Conclusions were drawn about the applicability of the NMR method not only in determining the authenticity of dalargin, but also in solving the problem of determining the content of the main substance and impurities. Conclusion. Authenticity methods have been developed in the substance – Dalargin powder by Mass, IR, and NMR spectrometry. It has been established that1H NMR spectrometry is a more informative method for authenticating. © Shulzhenko M. G., Vasilenko I. A., Ugrak B. I., Shohin I. E., Medvedev Yu. V., Malashenko E. A., 2020

Иммунотерапия

Руководство написано ведущими иммунологами и врачами разных специализаций, применяющими иммунотерапию в своей практике. В книге рассмотрены принципы иммунотерапии, механизмы действия иммунотропных препаратов и их применение в клинической практике. Описаны иммуноглобулины, пептиды тимуса, цитокины, интерфероны и их индукторы, бактериальные иммуномодуляторы и другие группы препаратов иммунной направленности. Представлены схемы применения иммуномодуляторов и результаты лечения инфекционных заболеваний респираторного и желудочно-кишечного трактов, мочевыделительной и репродуктивной систем, кожи и ее придатков, гепатитов, герпесвирусных инфекций, эндокринных заболеваний, различных видов аллергии. Значительное место уделено иммунотерапии в онкологии. Издание предназначено для врачей различных специальностей: терапевтов, педиатров, хирургов, урологов, дерматологов, микологов, венерологов, онкологов, эндокринологов, инфекционистов, аллергологов-иммунологов