THYROID DISEASES AND FEMALE REPRODUCTIVE HEALTH IN MAJOR ETHNIC GROUPS IN EASTERN SIBERIA

The paper presents the results of a retrospective analysis of reproductive and thyroid status in 1339 women (aged 27-45years) living in Eastern Siberia. 134 Mongoloid (Buryat) women and 1205 Caucasians (Russian women): 81 % women of infertile couples, 19 % of healthy women (control group) were established. High rates of hypothyroidism (18 %) in women with hyperprolactinemia and thyroid autoimmunity (7.9 and 7.2 %) in women with uterine fibroids, endometriosis and infertility, living in the Irkutsk region, was found. This study confirms the role of thyroid dysfunction in reproductive disorders. The median TSH in women with infertility Caucasians (Russian women) significantly exceeded the performance of TSH in the control group, especially in women with uterine fibroids and endometriosis. The median of FT4, the biologically active part of total thyroxin, in infertile women were in the range of reference values, were significantly lower than median of FT4 in the control group. In women with infertility, living in the Republic of Buryatia, thyroid disease was found in 2 times less compared to a resident of the Irkutsk region (14.1 % and 35 %; P (χ2) 0,05), in the structure of the thyroid diseases, in certain hormones concentrations TSH and FT4 in Russian and Buryat women with infertility, which requires further study. Discriminant analysis found the significance of changes in thyroid hormone for infertility in different ethnic groups: for infertile and fertile Russian women, living in the Republic of Buryatia, informative signs are indicators of TSH; for infertile and fertile Buryat women FT4; for women Caucasians with infertility, uterine fibroids and endometriosis, living in the Irkutsk region T3 and T4

THYROID FUNCTION AND REPRODUCTIVE HEALTH OF TEENAGE BOYS OF MAJOR ETHNIC GROUPS IN EASTERN SIBERIA

This paper presents the results of a retrospective analysis of epidemiological studies (2005-2011 years) continuous sampling method 320 adolescent boys aged 14-17 years living in the Irkutsk region (Irkutsk, Bratsk, Angarsk, v. Bay-anday): 282 boys Europeans, 30 Mongoloids, 8 Mitis. We compared the clinical, instrumental and laboratory data in adolescents, depending on where you live, the presence or absence of pathology and ethnic groups in the Russian, Buryat and Mitis. Ethnicity was determined by taking into account the phenotypic characteristics of the child and genealogical data history (children with parents in two generations of one ethnic group). The high frequency of goiter in teenage boys who live in the major industrial cities in the 2.63.4 times the figure given in the rural population (px2 0,05), living in rural areas, with no significant ethnic differences. However, the teenagers Caucasians living in urban areas, the puberty and physical development delay met in 2,5-1,4 times more often (33,8-58,3 %; px2 < 0,05). Our data support a role of thyroid dysfunction in the development of reproductive disorders, and therefore timely diagnosis, treatment and recovery of thyroid function is necessary for the prevention of infertility. The established differences in urban and rural adolescent boys suggest the influence of anthropogenic impact on the functioning of the endocrine and reproductive systems

ADOLESCENT REPRODUCTIVE HEALTH IN MAJOR ETHNIC GROUPS IN EASTERN SIBERIA LIVING IN COUNTRYSIDE

The paper presents the results of the cross-sectional epidemiological study of 96 teenagers of 14-17 years old of Mongoloid and Caucasoid populations living in countryside (village Bayanday, Irkutsk region). 3 ethnic groups were divided: 62 Mongoloid (Buryats, 65.3 %), 17 children of mixed marriages (metises; 17.9 %), 17 Caucasians (Russian, 16.8 %), including 47 boys(49.5 %, with an average age of 14,82 ± 0,79 years) and 49 girls (50.5 %, mean age 15,33 ± 0,15 years). The incidence of endocrine diseases, special ethnic characteristics of the endocrine and reproductive abnormalities and of certain hormones concentrations in Russian, mongrels and Buryat adolescents were established. Study of health major ethnic groups in Eastern Siberia, living in the countryside, set a higher frequency of reproductive abnormalities (with 43.7 % of girls and 31 % of boys). The high frequency of diseases of the endocrine system in Buryats and metises (50 % 52 %) compared to the Russian teens (12 %), basically hypothalamic syndrome of puberty and obesity. In 11-25 % of adolescents of studied ethnic and gender groups thyroid hyperplasia were established. However the median of FT4 and TSH were within the reference range, and the median of TSH was significantly higher in Russian teenagers both gender groups in comparison with the Mеtis and the Buryats. We have identified ethnic differences in the structure of the reproductive disease in boys: puberty delay and obesity, hyperprolactinaemia and testosterone decline, diagnosed more frequently in Mongoloids. Installed hormonal differences between groups of girls of the main ethnic groups suggest a role for testosterone in the reproductive disorders in Caucasians, prolactin the Mongoloid, which without appropriate correction can lead to infertility in reproductive age. The role of the environment on the development of hormonal disorders and the formation of the reproductive abnormalities in Caucasians, as identified by the hormonal changes teens Angarsk is 7-10 times higher than those found in adolescents Caucasian population living in countryside, which requires further study