On Spectrum of the Laplacian in a Circle Perforated along the Boundary: Application to a Friedrichs-Type Inequality

In this paper, we construct and verify the asymptotic expansion for the spectrum of a boundary-value problem in a unit circle periodically perforated along the boundary. It is assumed that the size of perforation and the distance to the boundary of the circle are of the same smallness. As an application of the obtained results, the asymptotic behavior of the best constant in a Friedrichs-type inequality is investigated

Reference information in integral anamnesis development

The article is devoted to semantic content of integral anamnesis - basic part of national integrated electronic health record. Integral anamnesis is a formalized set of the most important clinical data of a patient aimed at safety and continuous medical care both emergency and elective care. A short review of international projects of implementation and trans border exchange of key information about a patient is presented. Information content of integral anamnesis is presented which is developed in our country and includes 15 main sections: disability, benefits, social factors, addiction and occupational hazards, significant vital parameters, blood types and rhesus factor, pathological reactions, vaccination and immunization, epidemiological anamnesis, significant (dispensary) diseases, surgical interventions, medical devices and implants, pregnancies and deliveries, current medications and non-drug treatment. Administration, structure, problems, readiness of reference materials for coding of information presented in integral anamnesis are described. At the moment most of the necessary reference materials are finished and available on the portal of normative-reference information of the Ministry of Health of the Russian Federation (http://nsi.rosminzdrav.ru/): 20 basic and 7 additional ones. At the current stage it provides interoperability of medical information systems in integral anamnesis. Such time-consuming reference books as surgical interventions, instrumental diagnostic studies, federal reference book of medications are being actively developed. The section «Epidemiological anamnesis of a patient» stays practically unformalized. The first step in this direction is development of a reference book of immunobiological medications for specific prophylaxis, diagnosis and treatment. The aim of the study of semantic interoperability for integral anamnesis was reached by development of 27 reference books posted on the federal portal of normative-reference information of the Ministry of Health of Russia; the next stage should be development of technologies of formation and upgrade of the information of integral anamnesis

The High–Low Arctic boundary: How is it determined and where is it located?

Geobotanical subdivision of landcover is a baseline for many studies. The High–Low Arctic boundary is considered to be of fundamental natural importance. The wide application of different delimitation schemes in various ecological studies and climatic scenarios raises the following questions: (i) What are the common criteria to define the High and Low Arctic? (ii) Could human impact significantly change the distribution of the delimitation criteria? (iii) Is the widely accepted temperature criterion still relevant given ongoing climate change? and (iv) Could we locate the High–Low Arctic boundary by mapping these criteria derived from modern open remote sensing and climatic data? Researchers rely on common criteria for geobotanical delimitation of the Arctic. Unified circumpolar criteria are based on the structure of vegetation cover and climate, while regional specifics are reflected in the floral composition. However, the published delimitation schemes vary greatly. The disagreement in the location of geobotanical boundaries across the studies manifests in poorly comparable results. While maintaining the common principles of geobotanical subdivision, we derived the boundary between the High and Low Arctic using the most up‐to‐date field data and modern techniques: species distribution modeling, radar, thermal and optical satellite imagery processing, and climatic data analysis. The position of the High–Low Arctic boundary in Western Siberia was clarified and mapped. The new boundary is located 50–100 km further north compared to all the previously presented ones. Long‐term anthropogenic press contributes to a change in the vegetation structure but does not noticeably affect key species ranges. A previously specified climatic criterion for the High–Low Arctic boundary accepted in scientific literature has not coincided with the boundary in Western Siberia for over 70 years. The High–Low Arctic boundary is distinctly reflected in biodiversity distribution. The presented approach is appropriate for accurate mapping of the High–Low Arctic boundary in the circumpolar extent

Внутривидовая изменчивость цветочно-декоративных растений семейства Onagraceae и механизмы их сортообразования

The present review is devoted to intraspecific variability of floral and ornamental plants of the genus Clarkia purch. Family Onagraceae and clarification of the systematic status of the Godetia species introduced into Novosibirsk. Clarkia species from the Godetia and Rhodantos sections are noted for their particular beauty and duration of flowering. A comprehensive study of the influence of environmental conditions on genetic features of populations, ornamental qualities, flowering biology, morphogenesis, organogenesis, seed production and seed quality, agrotechnology’s of growing the above species of Clarkia, for selecting suitable forms and creating local varieties included in the basic assortment of flower crops for climatic conditions of Western Siberia as well as their introduction into urban gardening is necessary. The article discusses taxonomic markers important for determining the systematic position of Clarkia species from Godetia and Rhodantos sections in the family Onagraceae. Experimental data of genetic and cytological analyses carried out by foreign scientists for the last 100 years are presented, which give an idea of morphological, karyological characteristics and genetic variability in various species in the Godetia section. The mechanisms of inheritance of the flower colour trait and numerous variations in the position of the spot on the petals of different clarkia species have been established. Formation of the list of genes responsible for the Clarkia pigmentation system, location and size of the carmine spot will allow targeted selection for qualitative traits. The study of the pattern of multifactorial inheritance of habitus and flower shape traits among C. amoena subspecies contributes to the passage of the most decorative hybrid forms (varieties) as the starting material. In conclusion, a brief overview of promising species of the genus Clarkia from the Godetia and Rhodantos sections for ornamental plant breeding and selection is given.Настоящий обзор посвящен проблемам внутривидовой изменчивости цветочно-декоративных растений рода Clarkia Purch. семейства Onagraceae и уточнению систематического статуса интродуцированных в Новосибирск видов Godetia. Виды кларкии из секций Godetia и Rhodantos отличаются особой красотой и продолжительностью цветения. Для отбора перспективных форм и создания местных сортов, включенных в основной ассортимент цветочных культур для климатических условий Западной Сибири, а также внедрения их в городское озеленение необходимо всестороннее изучение влияния условий внешней среды на генетические особенности популяций, декоративные качества, биологию цветения, морфогенез, органогенез, семенную продуктивность и качество семян, агротехнику выращивания вышеуказанных видов кларкии. В статье рассматриваются таксономические маркеры, значимые для определения систематического положения видов Clarkia из секций Godetia и Rhodantos в семействе Onagraceae. Изложены экспериментальные данные генетического и цитологического анализов, проведенных зарубежными учеными за последние 100 лет, которые дают представление о морфологической, кариологической характеристике и генетической изменчивости у различных видов в секции Godetia. Установлены механизмы наследования признака окраски цветков и многочисленных вариаций положения пятна на лепестках разных видов кларкий. Формирование перечня генов, отвечающих за систему пигментации рода Clarkia, местоположение и размер карминового пятна, позволит вести направленный отбор по качественным признакам. Изучение картины многофакторного наследования признаков габитуса и формы цветка среди подвидов C. amoena способствует отбору наиболее декоративных гибридных форм (сортотипов) в качестве исходного материала. В заключение приводится краткий обзор перспективных видов рода Clarkia из секции Godetia и Rhodantos для декоративного растениеводства и селекции

THE STATE OF NUTRITIONAL STATUS AND ITS IMPACT ON THE LEVEL OF COMORBIDITY IN PATIENTS ON HEMODIALYSIS

The aim of the study was to investigate the nutritive status and identify risk factors for cardiovascular disease in patients on hemodialysis. Material and methods. 144 patients on program hemodialysis were examined. All patients underwent general clinical and laboratory examination, lipid profile was examined, body mass index was calculated, waist and hip circumference was measured, ratio of waist circumference to the circumference of hip was determined, abdominal integral multi-frequency bioimpedansometry and multispiral computed tomography were performed. Results. Gender features of distribution of abdominal adipose tissue and dyslipidemia in patients on program hemodialysis were revealed. Women have a predominant accumulation of visceral adipose tissue, while men are characterized by a proportional distribution of subcutaneous and visceral adipose tissue in the abdominal area. Women compared to men have higher rates of atherogenic lipoprotein fractions, which level is closely related to the volume of visceral adipose tissue. Among the comorbidities in the examined patients, diseases of the cardiovascular system predominate. The regression analysis revealed that the most significant risk factor for the development of coronary artery disease is an increase in lowdensity lipoproteins, for chronic heart failure – an increase in waist circumference. Conclusions. The data obtained indicate the need to monitor the nutritional status of patients on hemodialysis to identify and correct risk factors for cardiovascular disease

Search for the Cryptoexotic Member of the Baryon Antidecuplet 1/2+ in the Reactions pi- p --> pi- p and pi- p --> K L

The main goal of this proposal is the search for a narrow cryptoexotic nucleon resonance by scanning of the pi- p system invariant mass in the region (1610-1770) MeV with the detection of pi- p and K Lambda decays. The scan is supposed to be done by the variation of the incident pi- momentum and its measurement with the accuracy of up to +-0.1% (better than 1 MeV in terms of the invariant mass in the whole energy range) with a set of proportional chambers located in the first focus of the magnetooptical channel. High sensitivity of the method to the resonance under search is shown. The secondary particles scattered from a liquid hydrogen target are detected by sets of the wire drift chambers equipped with modern electronics. The time scale of the project is about 3 years. The budget estimate including manpower, the apparatus and operation cost, is about 40 million rubles. The beam time required is (4-6) two week runs on "high" (10 GeV/c) flattop of the ITEP proton synchrotron.Comment: 16 pages, 10 figures. v2: an acknowledge adde

Backward asymmetry measurements in the elastic pion-proton scattering at resonance energies

The asymmetry parameter P was measured for the elastic pion-proton scattering in the very backward angular region of theta_cm ~ 150-170^o at several pion beam energies in the invariant mass range containing most of the pion-proton resonances. The general goal of the experimental program was to provide new data for partial wave analyses in order to resolve their uncertainties in the baryon resonance region to allow the unambiguous baryon spectrum reconstructions. Until recently the parameter P was not measured in the examined domain that might be explained by the extremely low cross section. At the same time the predictions of various partial wave analyses are far from agreement in some kinematic areas and specifically those areas were chosen for the measurements where the disagreement is most pronouncing. The experiment was performed at the ITEP U-10 proton synchrotron, Moscow, by the ITEP-PNPI collaboration in the latest 5 years.Comment: 6 pages, 5 figures. to be submitted to the European Physical Journa

Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids

Violation of the extracellular matrix components synthesis regulation contributes to the formation and growth of uterine fbroids (MM). Changes of collagen metabolism in connective tissue may be associated with polymorphism of matrix metalloproteinase (MMP) genes. Aim of the study was to analyze of the association of regulatory regions of matrix metalloproteinase genes MMP2 (rs243865), MMP3 (rs3025058), MMP9 (rs3918242) with the development of uterine myoma, its histological form, several concomitant gynecological diseases. Material and methods. The clinical study of 69 patients (23–54 years old) with uterine myoma was conducted. According to the anamnesis, 57.9 % of patients had childbirth, 46.4 % of women had an artifcial termination of pregnancy, and 15.9 % of women had endometriosis. In histological examination, in 48.14 % the nodes corresponded to the phenotype of simple fbroids with a large proportion of fbrous tissue, 51.6 % with the phenotype of proliferating fbroids. The comparison group is represented by a random population sample of women from Western Siberia. 183 women without pronounced gynecological pathologies were examined. MMP2-1306 C/T polymorphism was analyzed by TaqMan, MMP3-1171 5A/6A, MMP9-1562 C/T by restriction fragment length polymorphism method. Results. The genotype frequencies of the analyzed genes did not signifcantly differ between the groups. The complex genotype MMP2-1306CC:MMP3-11715A6A:MMP9-1562CT was decreased in women with uterine myoma relative to the persons of the comparison group. In endometriosis patients MMP9-1562CC genotype was reduced and heterozygosity was increased relative to patients without endometriosis. The frequency of MMP2-1306CC:MMP9-1562CT complex genotype is signifcantly higher in women who gave birth than in women who did not give birth. Complex genotypes differences between histological variants of uterine myoma were revealed. Conclusions. The results of the study show the signifcance of polymorphism effect of the regulatory regions of the MMP genes in the development and nature of the course of uterine myoma