CARDIOLOGICAL ASPECTS OF THE JOINT HYPERMOBILITY SYNDROME

Objective: to identify the capacities of a Cardiovisor-06C device in the diagnosis of the cardiological aspects of the joint hypermobility syndrome (JHMS). Subjects and methods. The study covered 12 students with JHMS. All the respondents were examined using a Cardiovisor-06C device. Results. All the students were found to have deviations from the normal integral indicators: Myocardium, Rhythm, Pulse, Specification code, as well as some electrocardiogram indicators: the durations of P-Q and Q-T intervals and P wave. Conclusion. The early and preclinical manifestations of possible heart abnormalities in the JHMS can be detected by a Cardiovisor-06C device

CARDIOVASCULAR RISK FACTORS AND SELECTED PARAMETERS OF ECG DISPERSION MAPPING IN MEDICAL STUDENTS

Aim. To investigate the association between the risk factors (RFs) of cardiovascular disease (CVD) and selected parameters of ECG dispersion mapping in medical students, in order to facilitate preclinical diagnostics and timely risk management.Material and methods. The study included 72 students of the Internal Disease and Paediatrics Faculties of the N. N. Burdenko Voronezh State Medical Academy, aged 21–26 years (mean age 21,9±0,1 years; 18 men and 54 women). The examination included a questionnaire survey on CVD RFs, a clinical assessment, and the measurement of hemodynamic parameters. ECG parameters, including such integral characteristics as “Myocardium”, “Rhythm”, and “Detail Code”, were assessed both at rest and during the physical stress test, using the Cardiovisor 6C device.Results. All participants were divided into two groups. In the group with multiple CVD RFs, the distribution of these factors was as follows: 40% smoked (n=6), 53% consumed 2–3 drinks of alcohol per occasion (n=8), 40% had high normal blood pressure (BP) or Stage 1 elevation of BP, based on the office measurement data (n=6). Three (20%) and 4 (27%) students were overweight (OW) and obese (O; Stage I), respectively. Low physical activity (PA) was reported by 14 students (93%), and moderate to high levels of stress by 67% (n=10) and 33% (n=5), respectively. Immediately after the physical stress test and 2 minutes later, the “Myocardium” parameter was ≥17%, being significantly different from the values observed in students without multiple RFs. Abnormal values of the integral parameters of ventricular depolarisation and left ventricular repolarisation suggest the myocardial electrical heterogeneity among students with multiple CVD RFs.Conclusion. Students with multiple CVD RFs, such as smoking, alcohol, elevated BP, OW, Stage I O, moderate to high stress levels, and low PA, also demonstrated the myocardial electrical heterogeneity during the physical stress test

Features of the Intestinal Microbiota in Patients with Inflammatory Intestinal Diseases

Introduction. Inflammatory bowel diseases (IBD) occupy a leading position in the structure of diseases of the gastrointestinal tract (GIT), as they are a progressive chronic pathology with an autoimmune type of inflammation. Changes in the composition of the gut microbiota can determine morphological changes at the latent stage of the disease. Aim of the study. To assess the genus-­species biodiversity of the microbiota in patients with IBD. Patients and methods. 16S rRNA sequencing of the intestinal microbiota was performed in 15 patients with confirmed ulcerative colitis (UC) and 20 healthy controls. The parameters of the full blood count and the serum level of C-reactive protein (CRP) were analyzed. The analysis of the obtained data was carried out using Microsoft Excel and Statistica software. Results. Among the studied laboratory parameters in patients with IBD, there was a significant increase in CRP, leukocyte and neutrophil counts compared to the control group. Sequencing of the gut microbiota showed a decrease in the normobiota, as well as an increase in the representatives of the pathogenic cluster. Conclusion. In the present study, we demonstrated a decrease in the biodiversity of the gut microbiota in patients with IBD compared to the control group, a significant change in the pathogenic cluster, and an imbalance between the representatives of Bacteroidetes and Firmicutes