9 research outputs found
ΠΠ°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠΏΠ°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΏΠ»Π΅Π³ΠΈΠΈ
Hereditary spastic paraplegias represent a group of hereditary neurodegenerative disorders predominantly affecting corticospinal tracts which manifest with prominent spasticity and reduced power in the muscles of the lower limbs. According to clinical signs hereditary spastic paraplegias are divided into uncomplicated (classic) and complicated forms, according to the nature of inheritance β into autosomal dominant, autosomal recessive and X-linked. Mechanisms of the development of hereditary spastic paraplegias depend on the form and could be associated with misfolding of the proteins in endoplasmatic reticulum, mitochondrial dysfunction, changes in the cholesterol metabolism etc. Diagnosis is made after exclusion of other disorders of the central nervous system and could be confirmed by molecular genetic methods. Treatment of hereditary spastic paraplegias is symptomatic.ΠΠ°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠΏΠ°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΏΠ»Π΅Π³ΠΈΠΈ β Π³ΡΡΠΏΠΏΠ° Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΡΡΠΈΠΊΠΎΡΠΏΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΎΡΠ²Π»ΡΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠΏΠ°ΡΡΠΈΡΠ½ΠΎΡΡΡΡ ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΈΠ»Ρ Π² ΠΌΡΡΡΠ°Ρ
Π½ΠΈΠΆΠ½ΠΈΡ
ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ. ΠΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌ Π²ΡΠ΄Π΅Π»ΡΡΡ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠ΅ (ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅) ΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠ΅ ΡΠΎΡΠΌΡ, ΠΏΠΎ ΡΠΈΠΏΡ Π½Π°ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β Π°ΡΡΠΎΡΠΎΠΌΠ½ΠΎ-Π΄ΠΎΠΌΠΈΠ½Π°Π½ΡΠ½ΡΠ΅, Π°ΡΡΠΎΡΠΎΠΌΠ½ΠΎ-ΡΠ΅ΡΠ΅ΡΡΠΈΠ²Π½ΡΠ΅ ΠΈ Π₯-ΡΡΠ΅ΠΏΠ»Π΅Π½Π½ΡΠ΅. ΠΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΏΠ°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΏΠ»Π΅Π³ΠΈΠΉ Π·Π°Π²ΠΈΡΡΡ ΠΎΡ ΡΠΎΡΠΌΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΠΌΠΈΡΡΠΎΠ»Π΄ΠΈΠ½Π³ΠΎΠΌ Π±Π΅Π»ΠΊΠΎΠ² Π² ΡΠ½Π΄ΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅ΡΠΈΠΊΡΠ»ΡΠΌΠ΅, ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠ΅ΠΉ, Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΈ ΠΏΡΠΎΡ. ΠΠΈΠ°Π³Π½ΠΎΠ· Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΏΠ°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΏΠ»Π΅Π³ΠΈΠΉ ΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
, ΠΏΡΠΈ ΠΈΡΠΊΠ»ΡΡΠ΅Π½ΠΈΠΈ Π΄ΡΡΠ³ΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ. ΠΠ΅ΡΠ΅Π½ΠΈΠ΅ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΏΠ°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΏΠ»Π΅Π³ΠΈΠΉ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅
The impact of the first wave of the novel coronavirus infection (COVID -19) pandemic on the volume of diagnostic studies of cardiac diseases in the Russian Federation: results of the Russian segment of the INCAPS COVID international study under the auspices of the IAEA
ΠΠΏΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½Π° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ Π²Π·ΡΠΎΡΠ»ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎ ΡΠΏΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ Π°ΡΡΠΎΡΠΈΠ΅ΠΉ 5q Π² Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠ΅ ΠΠ°ΡΠΊΠΎΡΡΠΎΡΡΠ°Π½
Background. Spinal muscular atrophy (SMA) affects 1 in 11,000 people. Until 2016, this was considered an incurable disease, but after the approval of nusinersen, the situation has changed. The efficacy of nusinersen therapy is also known in adult patients, although research is limited due to the majority of studies in infants and children. Nusinersen has been included in the list of βVital and Essential Medicinesβ since 2021.Aim. To analyze the experience of using nusinersen as a pathogenetic therapy for patients over 18 years of age with SMA 5q in the Republic of Bashkortostan.Materials and methods. We examined eight patients receiving pathogenetic therapy with nusinersen (SMA type 2 β 34.5 %, SMA type 3 β 65.5 %). The Hammersmith Functional Motor Scale Expanded (HFMSE) and the Revised Upper Limb Module (RULM) were used for evaluating the effectiveness of therapy.Results. The median increase on the HFMSE scale was +2 points (7.5, with the initial 5.5) and on the RULM scale β +4.5 points (17 points, with the initial 12.5). Clinically, this was expressed in an increase in muscle strength, an increase in daily activity; a decrease in bulbar, respiratory and vegetative disorders can also be noted. Subjectively, positive dynamics was noted in the increase in working capacity, improvement of the emotional background.Conclusion. The use of the drug nusinersen in adult patients with SMA 5q in some cases provides clinical improvement. The presence of an βoverall responseβ is defined as clinically significant change in one assessed measure of motor function.Β ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. Π‘ΠΏΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ Π°ΡΡΠΎΡΠΈΠ΅ΠΉ (Π‘ΠΠ) Π±ΠΎΠ»Π΅Π΅Ρ 1 ΠΈΠ· 13 ΡΡΡ. ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ. ΠΠΎ 2016 Π³. ΠΎΠ½Π° ΡΡΠΈΡΠ°Π»Π°ΡΡ Π½Π΅ΠΈΠ·Π»Π΅ΡΠΈΠΌΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ, Π½ΠΎ ΠΏΠΎΡΠ»Π΅ ΠΎΠ΄ΠΎΠ±ΡΠ΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½ ΡΠΈΡΡΠ°ΡΠΈΡ ΠΈΠ·ΠΌΠ΅Π½ΠΈΠ»Π°ΡΡ. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½ΠΎΠΌ ΠΈΠ·Π²Π΅ΡΡΠ½Π° ΠΊΠ°ΠΊ Ρ Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΠ°ΠΊ ΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ. Π‘ 2021 Π³. Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½ Π²ΠΊΠ»ΡΡΠ΅Π½ Π² ΠΠ΅ΡΠ΅ΡΠ΅Π½Ρ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΡ
ΠΈ Π²Π°ΠΆΠ½Π΅ΠΉΡΠΈΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π΄Π»Ρ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΎΠΏΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΡΠ°ΡΡΠ΅ 18 Π»Π΅Ρ ΡΠΎ Π‘ΠΠ 5q Π² Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠ΅ ΠΠ°ΡΠΊΠΎΡΡΠΎΡΡΠ°Π½.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ°ΠΌΠΈ Π±ΡΠ»ΠΈ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 8 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°ΡΡΠΈΡ
ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½ΠΎΠΌ (Π‘ΠΠ 2-Π³ΠΎ ΡΠΈΠΏΠ° β 34,5 %, Π‘ΠΠ 3-Π³ΠΎ ΡΠΈΠΏΠ° β 65,5 %). ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ Π Π°ΡΡΠΈΡΠ΅Π½Π½Π°Ρ ΡΠΊΠ°Π»Π° ΠΎΡΠ΅Π½ΠΊΠΈ ΠΌΠΎΡΠΎΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ Π±ΠΎΠ»ΡΠ½ΠΈΡΡ Π₯Π°ΠΌΠΌΠ΅ΡΡΠΌΠΈΡ (Hammersmith Functional Motor Scale Expanded, HFMSE) ΠΈ ΠΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠ΅Π½Π½ΡΠΉ ΠΌΠΎΠ΄ΡΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠ΅ΠΉ (Revised Upper Limb Module, RULM).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΡΠ΅Π΄Π½Π΅Π΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ β 7,25. ΠΠΎΠ·ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ ΠΌΠ΅Π΄ΠΈΠ°Π½Ρ ΠΏΠΎ ΡΠΊΠ°Π»Π΅ HFMSE ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ +2 Π±Π°Π»Π»Π° (7,5; ΠΏΡΠΈ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΉ 5,5 Π±Π°Π»Π»Π°), Π° ΠΏΠΎ ΡΠΊΠ°Π»Π΅ RULM β +4,5 Π±Π°Π»Π»Π° (17; ΠΏΡΠΈ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΉ 12,5 Π±Π°Π»Π»Π°). ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ ΡΡΠΎ Π²ΡΡΠ°ΠΆΠ°Π»ΠΎΡΡ Π² ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΈΠ»Ρ, ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠ²ΡΠ΅Π΄Π½Π΅Π²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²; ΡΠ°ΠΊΠΆΠ΅ ΠΌΠΎΠΆΠ½ΠΎ ΠΎΡΠΌΠ΅ΡΠΈΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ Π±ΡΠ»ΡΠ±Π°ΡΠ½ΡΡ
, Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΈ Π²Π΅Π³Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ. Π‘ΡΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π²ΡΡΠ°ΠΆΠ°Π»Π°ΡΡ Π² ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ, ΡΠ»ΡΡΡΠ΅Π½ΠΈΠΈ ΡΠΌΠΎΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ½Π°.ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π½ΡΡΠΈΠ½Π΅ΡΡΠ΅Π½ Ρ Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎ Π‘ΠΠ 5q Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅. ΠΠ°Π»ΠΈΡΠΈΠ΅ Β«ΠΎΡΠ²Π΅ΡΠ° Π² ΡΠ΅Π»ΠΎΠΌΒ» ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ ΠΊΠ°ΠΊ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ 1 ΠΎΡΠ΅Π½ΠΈΠ²Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ.
Current status of nuclear cardiology in the Russian Federation
The article is devoted to the analysis of the current status of nuclear cardiology in the Russian Federation. The data on the number of facilities performing radionuclide investigations for the diagnosis and monitoring of the treatment of cardiovascular diseases, their staffing and equipment are given. The statistics of the conducted nuclear cardiology tests for 2018-2020 are given, as well as their methods, features and diagnostic significance are described
Analysis of the restoration of cardiology diagnostics scope in the Russian Federation during the COVID-19 pandemic: results of the Russian segment of the INCAPS COVID 2 study under the auspices of the International Atomic Energy Agency
Aim. To assess the changes in cardiology diagnostics scope in the Russian Federation during the coronavirus disease 2019 (COVID-19) pandemic.Material and methods. In an online survey organized by the Division of Human Health of the International Atomic Energy Agency (IAEA), including questions about changes in the workflow of diagnostic laboratories and the scope of cardiac diagnostics from March 2019 (pre-pandemic) to April 2020 (first wave of the pandemic) and April 2021 (recovery stage), 15 Russian medical centers from 5 cities took part.Results. The decrease in the diagnostics scope by April 2020 by 59,3% compared to March 2019, by April 2021, stopped and was replaced by growth (+7,1%, the recovery rate, 112,1%). The greatest increase was in routine examinations, such as echocardiography (+11,6%), stress echocardiography (+18,7%), stress single photon emission computed tomography (+9,7%), and to a lesser extent resting computed tomography angiography (+7,0%) and magnetic resonance imaging (+6,6%). The performance of stress electrocardiography, stress magnetic resonance imaging and positron emission tomography for the diagnosis of endocarditis in April 2021 compared to March 2019 decreased by 10,3%, 63,2% and 62,5%, respectively.Conclusion. Due to the resumption of patient admissions for cardiac examinations during the ongoing COVID-19 pandemic, with the anti-epidemic measures taken and certain changes in the workflow, there has been a recovery in the diagnostics scope in most of the included centers
Gaucher disease type 2 (case report)
The article describes a rare clinical case of Gaucher disease in a 5 month old girl, confirmed by molecular genetic analysis. In the presented clinical case, there is a onset of lysosomal accumulation disease, which is accompanied by changes in the clinical analysis of blood (anemia, thrombocytopenia), hepatosplenomegaly, congenital malformations (open arterial duct, open oval window) and severe neurologic deficit
Impact of the first wave of coronavirus disease 2019 (COVID-19) pandemic on the diagnosis of heart disease in the Russian Federation: results from the Russian segment of the IAEA INCAPS COVID study
Aim. To assess the impact of the first wave of coronavirus disease 2019 (COVID-19) pandemic on the diagnosis of heart disease in the Russian Federation.Material and methods. Fifteen Russian medical centers from 5 cities took part in an online survey organized by the Division of Human Health of the International Atomic Energy Agency (IAEA), containing questions regarding alterations in cardiovascular procedure volumes resulting from COVID-19 in March-April 2020.Results. A number of outpatients undergoing cardiac diagnostic procedures was noted in 80% of clinics. Cardiovascular procedure volumes in the period from March 2019 to March 2020 in general decreased by 9,5%, and from March 2019 to April 2020, by 56,5%. Stress electrocardiography decreased by 38,4%, stress echocardiography by 72,5%, stress single-photon emission computed tomography by 66,9%, computed tomography angiography by 49,7%, magnetic resonance imaging by 42,7%, invasive coronary angiography by 40,7%. The decrease in diagnostic procedure volumes in selected regions (Tomsk Oblast, Kemerovo Oblast, Tatarstan) was not so pronounced compared to Moscow and St. Petersburg (-20,7%, -75,2%, -93,8% in April 2020, respectively, p<0,001).Conclusion. The first wave of the COVID-19 pandemic caused a sharp decrease in the number of diagnostic cardiac procedures in Russia. This has potential longterm implications for patients with cardiovascular disease. Understanding these implications can help guide diagnostic strategies during the ongoing COVID-19 pandemic and minimize the future losses
Impact of the first wave of coronavirus disease 2019 (COVID-19) pandemic on the diagnosis of heart disease in the Russian Federation: results from the Russian segment of the IAEA INCAPS COVID study
Aim. To assess the impact of the first wave of coronavirus disease 2019 (COVID-19) pandemic on the diagnosis of heart disease in the Russian Federation. Material and methods. Fifteen Russian medical centers from 5 cities took part in an online survey organized by the Division of Human Health of the International Atomic Energy Agency (IAEA), containing questions regarding alterations in cardiovascular procedure volumes resulting from COVID-19 in March-April 2020. Results. A number of outpatients undergoing cardiac diagnostic procedures was noted in 80% of clinics. Cardiovascular procedure volumes in the period from March 2019 to March 2020 in general decreased by 9,5%, and from March 2019 to April 2020, by 56,5%. Stress electrocardiography decreased by 38,4%, stress echocardiography by 72,5%, stress single-photon emission computed tomography by 66,9%, computed tomography angiography by 49,7%, magnetic resonance imaging by 42,7%, invasive coronary angiography by 40,7%. The decrease in diagnostic procedure volumes in selected regions (Tomsk Oblast, Kemerovo Oblast, Tatarstan) was not so pronounced compared to Moscow and St. Petersburg (-20,7%,-75,2%,-93,8% in April 2020, respectively, p<0,001). Conclusion. The first wave of the COVID-19 pandemic caused a sharp decrease in the number of diagnostic cardiac procedures in Russia. This has potential long-term implications for patients with cardiovascular disease. Understanding these implications can help guide diagnostic strategies during the ongoing COVID-19 pandemic and minimize the future losses