Early echocardiographic alterations in cancer patients during chemotherapy

Aim. To evaluate the early manifestation of cardiotoxicity after the first course of multiagent chemotherapy (MAC) using echocardiography with an assessment of the left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS).Material and methods. The study included 49 cancer patients with elective MAC.Results. After the first administration of a therapeutic dose of chemotherapy, a decrease in LVEF ≥10 and GLS >15 was demonstrated in more than 6,1% of patients, as well as a subclinical decrease in LVEF ≥5% in 22,4% and a decrease in GLS ≥12% in 24,5%.Conclusion. In cancer patients, after the first course of chemotherapy, GLS dynamics should be assessed during echocardiography as a marker of myocardial dysfunction

Subthalamic Nucleus Deep Brain Stimulation for treatment in patients with advanced Parkinson's disease: One-year comparative research

This study to assess the shot-term efficacy and safety of chronic bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease (PD). 54 consecutive patients with idiopathic Parkinson's disease treated with bilateral stimulation of the STN were studied. Parkinsonian status was assessed preoperatively and at 1 years postoperatively using the UPDRS scale in on and off-medication conditions. At 1 years follow-up, STN stimulation reduced the UPDRS motor score by 52,3 % compared to baseline in the OFF-medication conditions. Tremor, rigidity, bradykinesia, postural stability and gait (PIGD) improved by 63,9 %, 53,9 %, 46,8 %, 48,4%, respectively. UPDRS part II scores were reduced by 50,78 %. The overall dopaminergic drugs dose was reduced by 64,6 % after surgery. Our data demonstrate that: bilateral STN stimulation is relatively safe, improves the motor symptoms and drug-related motor complications of PD, and reduces the daily dosage of medication.Данное исследование посвящено оценке эффективности электростимуляции (ЭС) субталамического ядра (STN) на развернутой стадиях болезни Паркинсона (БП). Обследовано 54 пациента с идиопатинеской БП, которым была проведена ЭС STN. Состояние пациентов оценивалось через год с помощью шкалы UPDRS в ON- и OFF-периоде. ЭС STN уменьшила тяжесть двигательных нарушений по шкале UPDRS III на 52,3% по сравнению с дооперационным уровнем. Тремор, ригидность, брадикинезия, постуральные нарушения уменьшились на 63,9 %, 53,9 %, 46,8 %, 48,4% соответственно. Повседневная активность (UPDRS II) улучшилась в OFF-периоде на 50,78 %. Эквивалентная доза леводопы была уменьшена на 64,6 %. Данное исследование продемонстрировало улучшение двигательных симптомов, уменьшение выраженности осложнений фармакотерапии, а также дозы леводопы

Place of imidazoline receptor agonists in the treatment of arterial hypertension

The review is devoted to one of the most controversial issues of modern antihypertensive therapy — the role of new generation sympatholytics — selective I1-imidazoline receptor agonists (AIRs). In modern European recommendations, AIR (moxonidine rilmenidine), along with other centrally acting drugs (reserpine, alpha-methyldopa, clonidine), are mainly intended for additional therapy in rare cases of resistant hypertension, when other treatment options have been ineffective. Nevertheless, AIR invariably finds its place in Russian recommendations for the treatment of arterial hypertension (AH). This class of drugs is recommended for patients with AH in combination with metabolic syndrome and obesity. It is noted that an important property of AIR is its positive effect on carbohydrate and lipid metabolism. This information is based on an analysis of Russian and foreign studies, which convincingly indicate that this class of drugs not only provides adequate and long-term blood pressure control, but also has the above-mentioned positive metabolic effects. At the same time, AIRs are much less likely to cause side effects characteristic of older generation centrally acting drugs. Thus, AIRs have become firmly established in clinical practice in Russia for the treatment of patients with AH in certain clinical situations

PHYLLOIDES TUMOR OF THE PROSTATE: A REVIEW OF LITERATURE AND A CASE REPORT

Phyllodes tumor of the prostate is a rare neoplasm with poorly understood pathogenesis. Histologically, it resembles phyllodes tumor of the breast with hyperplastic epithelium lined cysts and channels embedded in a variably cellular stroma. A variety of terms have been used to describe these lesions, including phyllodes type of atypical hyperplasia, cystosarcoma phyllodes. The malignant potential of this tumor is unclear and has resulted in confusion in terms of prognosis and treatment.</p

SCHOOL OF HEALTH FOR PATIENTS WITH CARDIO-VASCULAR DISEASES: BALANCE BETWEEN ANDRAGOGIC AND PEDAGOGIC EDUCATIONAL MODELS

Problems of educational programs for patients with cardio-vascular diseases in schools of health are discussed. Comparison of andragogic (adult education) and pedagogic education models are analyzed. The pedagogic education model is currently dominating in school of health. To increase of education efficacy in school of health implementation of andragogic principles is recommended. </p

THE REVIEW OF RUSSIAN PUBLICATIONS DURING THE YEARS 2010-2014. THE USE OF SCOPUS DATABASE FOR THE EVALUATION SPEED INTEGRATING INTO WORLDWIDE SCIENTIFIC SOCIETY

The article focuses on the descriptive analysis of structure and dynamics of publication activity of Russian authors in medicine in the international database Scopus in 2010-2014 yy. The increase was noted of international collaboration and orientation to publishing in Englishlanguage international magazines that makes to expect further improvement of indicating values that are in use in Federal system of efficacy and results of scientific institution evaluation. The descriptive approach that has been used can be applied for the articles investigation in any area and for governing decisions for planning of scientific investigations

EFFECT OF ANTIHYPERTENSIVE THERAPY ON METABOLIC PROFILE AND ERECTILE FUNCTION IN HYPERTENSIVE MEN WITH HIGH CARDIOVASCULAR RISK: FOCUS ON THE COMBINATION OF LISINOPRIL AND AMLODIPINE

Aim. To study the antihypertensive and metabolic effects of lisinopril plus amlodipine combination in hypertensive men with high cardiovascular risk.Materials and methods. Hypertensive men (n=21) with high cardiovascular risk (SCORE scale &gt;5%) aged 30-59 y.o. were included in the study. Questionnaire survey, blood pressure (BP) and heart rate measuring, anthropometric studies, evaluation of the plasma lipid profile, uric acid level and glucose tolerance test were performed at baseline and at the end of the study. Erectile function was assessed by International index of erectile function (IIEF) score. After the cancellation of previous antihypertensive drugs patients were prescribed lisinopril 10 mg QD and amlodipine 5 mg QD. The duration of the study was 6 months.Results. In 4 weeks of the treatment systolic and diastolic BP decreased by 9.3 and 5.2%, and in 24 weeks – by 14.7 and 7.2% respectively (p&lt;0.05). Target BP levels were achieved in 85% of patients. Antihypertensive therapy during 6 months had no significant effect on the plasma lipid profile, glucose and uric acid levels. The mild to moderate-mild erectile dysfunction were detected in 35% of men before therapy. Erectile function indices in hypertensive men with high cardiovascular risk had not changed during combined antihypertensive therapy.Conclusion. Antihypertensive therapy with lisinopril and amlodipine in hypertensive men with high cardiovascular risk during 6 months led to a statistically significant reduction of BP level without affect plasma lipid profile, glucose and uric acid levels as well as erectile function

The Role of Magnesium in the Development of Cardiovascular Diseases and the Possibility of their Prevention and Correction with Magnesium Preparations (Part 1)

The article is devoted to the influence of magnesium on the homeostasis of the body and, in particular, on the cardiovascular system. It describes the importance of the presence and effects of magnesium on various key processes and functions occurring in the body. The reasons for the lack of magnesium and ways to replenish it both in the natural way (eating, certain foods) and magnesium preparations are considered. The article provides examples of large randomized studies that prove the importance of the influence of normal magnesium levels on human health in general and on the state of the cardiovascular system. These studies show how magnesium deficiency increases the risk of cardiovascular diseases and how it can be reduced. It is also shown which trace elements and vitamins are closely related to magnesium metabolism, and how they (in particular, potassium and vitamin B6) improve and facilitate the normalization of magnesium levels. It is noted how comorbidity decreases with the normalization of magnesium level – the higher the magnesium level in the blood plasma (closer to the upper limit and more), the less comorbidity and longer life expectancy. Magnesium is an absolutely essential ion and a good medicine. Magnesium deficiency and hypomagnesemia are quite common, difficult to diagnose (due to underestimation and rare level control) and accompany many diseases of the cardiovascular system and beyond. The widespread use of organic magnesium salts would improve the situation as a whole, due to their universal multiple effect on many processes in the body. This is an integral part of therapeutic and preventive measures in patients with already existing diseases and in people who do not have diseases, but who are at risk due to existing hypomagnesemia

Bivalos (strontium ranelate) administration experience in postmenopausal osteoporosis

Происходящие при остеопорозе (ОП) изменения костной ткани приводят к хрупкости костей и склонности к переломам. Постменопаузальный ОП широко распространен, и у 40% женщин в этот период происходят переломы, связанные со снижением костной массы [18]. Основной целью лечения ОП является не только уменьшение частоты переломов позвонков и периферических костей, но и сохранение социальной активности, связанное с качеством жизни пациента. В связи с этим постоянно ведется поиск препаратов, нормализующих костный обмен, хорошо переносимых и удобных для приема с учетом долгосрочности проводимой терапии. В настоящее время наиболее широко используемым классом лекарственных средств для лечения ОП считают антирезорбтивные препараты. Цель: изучить эффективность Бивалоса по влиянию на минеральную плотность кости (МПК), специфические маркеры костного обмена, качество жизни пациентки и оценить переносимость препарата