PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA

ApoE vector protein in association with apoB-100 directly transferring saturated and monounsaturated FA (SFA and MFA) in triglyceride form (composed of very low density lipoproteins (L)) to the cells which are assimilating FA by cooperative receptors of apoE. Only insulin dependent cells have apoe/B-l00 receptors on the cell membrane (skeletal myocytes, cardiac myocytes, periportal hepatocytes, adipocytes of subcutaneous fat and Kupffer's macrophages). Phylogenetically late apoE has a domain for protein-protein interaction unlike the other apos. Apo forms cooperative ligands: apoE/A-l, apoE/B-48 and apoE/B-100 while using this domain. At later stages of phylogenesis while apoE forms cooperative ligands it is also involved in cell transfer and absorption of polyunsatured essential fatty acids in high density L, SFA +MFA +unsatured FA in chylomicrons, SFA+MFA in very low density L. Phenotype E 33 appears to be regular. Phenotypes E2/2 and E4/4 are cause of hypertriglyceridemia of I and V types, which call destructive inflammation of arterial intima with atherothrombosis

Determining the frequency of polymorphisms rs3846663 of HMGR gene and c.521T>C of SLCO1B1 gene in the population of Krasnoyarsk

Генетические полиморфизмы ферментативных и транспортных систем способны влиять на эффективность лекарственных средств, а также приводить к возникновению побочных эффектов. Мы проанализировали распространенность полиморфизмов rs3846663 гена HMGR и с.521T>C гена SLCO1B1 у населения г. Красноярска. Частота мутантного аллеля первого полиморфизма составила 43%, второго – 20%, что соответствует данным, полученным в других исследованиях.Genetic polymorphisms of enzymatic and transport systems are able to influence on the effectiveness of drugs, as well as lead to the occurrence of side effects. We had analyzed the prevalence of polymorphisms rs3846663 of HMGR gene and c.521T>C of SLCO1B1 gene in the population of Krasnoyarsk. The allele’s frequency of first polymorphism was 43%, the second - 20%, which complies with the data obtained in other studies