TREATMENT OF ERECTILE DYSFUNCTION IN PATIENTS WITH VIBRATION DISEASE CAUSED BY EXPOSURE OF LOCAL VIBRATION

The article presents the results of complex treatment of erectile dysfunction of 38 patients with vibration disease of II degree. The diagnosis of erectile dysfunction was proved by clinical and instrumental data, besides we carried out survey with determination of international index of erectile dysfunction. Treatment complex included homeopathic remedies, vasodilating ointment for local application and physiotherapeutic procedures. Improvement of the indices of phallography and. the index of erectile dysfunction was registered on the basis of treatments. Total effectiveness of the therapy was 89,9 %

CLINICAL VALUE OF REGULATORY AUTOANTIBODIES IN DEVELOPMENT OF NEUROINTOXICATION WITH METALLIC MERCURY VAPOURS

We studied the changes in content of the autoantibodies to the antigens from nervous tissue was performed in the employees contacting with, metallic mercury, in the patients with, the mercury intoxication, at the different stages of the pathological process. It was found that small increase of concentrations of the autoantibodies to the protein S-100 in the "practically" healthy employees may be considered, as the protective physiological mechanism.. Influence of the mercury on the employees' organisms promotes the change of autoimmune reactions that are characterized by the increase of content of antibodies to the brain-specific proteins in blood serum.. The decrease of the antibody levels in patients with chronic mercury intoxication, in remote period and the increase of severity of pathological process testifies to the dysregulation in the immune system.. It was determined, that the increase of autoantibodies to MAG was typical only for the patients with chronic mercury intoxication. (CMI), thereby, higher levels of autoantibodies were observed in the patients with more dominated cognitive disorders in comparison with the patients with more dominated asthenic disorders. In healthy employees and the ones of "risk group" concentrations of autoantibodies to MAG were at the level of control. Increased, levels of autoantibodies to MAG testify to the formation of neurodegenerative changes and. are one of the diagnostic criteria

Vibration influence on functional activity of nervous system in experimental animals

The production vibration is known to be a powerful stressor which may induce the complex of disorders leading to the vibration-induced disease development. Along with the appearance of the clinical syndromes the neurosis-like, the psychoemotional disorders, the ipochondric, asthenic and asthenovegetative syndromes, the diffuse disorders of the bioelectrical brain activity with the participation of the cortex of the large hemispheres as well as the stem and diencephalic brain structures were observed to occur in the patients with the vibration-induced disease. However, at present there are no clear arguments in favour that namely the exposure to vibration may promote the occurrence of the neurotic disorders, the neurosis-like disorders of psychic activity, the disadaptation signs, the emotional disorders as well as the pathological changes in the bioelectrical brain activity in exposure to vibration. This work aimed to reveal the changes in the central nervous system (CNS) based on the study results of the behavior and bioelectrical brain activity in the animals. The experimental studies were performed using the mature inbreeding rats males. The chronic experiment was performed by means of the modificated vibrostend VEDS-10a, the vibration levels taken corresponded to the exposure in reality to vibration under production conditions. The studies were performed based on 4 study series: for 15 days, one, two, and four months of exposure to vibration. The intact rats were used as the control ones. The animal behavior responses with assessing the motor activity, the orientating and learning as well as the emotional behavior components were observed in the «юрen field». Recording and processing the electroencephalographic data were performed using the electroencephalograph Neuron-spectrum 4 (Joint-Stock Company «Neurosoft», Russia). The information was processed using the standard methods of the variation statistica, statistical processing the data was performed by means of the Packet of Applied Programs EXCEL Packet Office 2003 (in OS «W1NDOWS Xp»), «Statistica for windows - Version 6». The study of the behavior activity in the animals has shown that the increase in the common motor activity, the nonspecific character, the high emotional strain of the negative character, the negative emotional state were found to occur in the rats exposed to vibration, thereto, the orientating and learning activity was at the previous level. The change in the bioelectrical brain activity was characterized by the increase in the slow-wave activity of the delta-range after one month of exposure to vibration and the latent period prolongation of the visual induced potentials (V1P) after 15 days of exposure to vibration

VALUE OF BRAIN STRUCTURE DYSFUNCTION IN PATHOGENESIS AND FORMATION OF CLINICAL PICTURE OF VIBRATION INDUCED DISEASE

The examination of 130 men including neurological examination and. computer electroencephalography with determining of equivalent dipolar sources of pathological activity was performed. Three main groups included employees with a long-term working period exposed by a complex of unfavourable production factors (the local, the whole body vibration, supercooling, physical stress), the patients with occupational polyneuropathy after exposure by a complex of unfavourable factors and. the patients with the vibration-induced diseases due to the local vibration. The study results showed the common signs of the change in bioelectrical brain activity which were found to be characteristic for studied groups compared with clinical symptomatic complex as well as distinguishing features

METHODS OF NON-DRUG THERAPY IN PATIENTS WITH POLYNEUROPATHY CAUSED BY COMBINED ACTION OF GENERAL VIBRATION AND PHYSICAL ACTIVITY

We carried out comparative estimation of treatment of polyneuropathy of extremities caused by exposure of general vibration and physical activity with use of travelling magnetic field on the extremity and. organ-mineral napkins on the basis of "extraction" of sludge dirt rich with mineral salts and. wide complex of microelements. As the result of performed therapy we registered regress of main symptoms and. improvement of electrophysiological indices

OPPORTUNITIES OF USE OF THE BIOFEEDBACK METHOD IN REHABILITATION OF PATIENTS WITH OCCUPATIONAL DISEASES CAUSED BY CHEMICAL AND PHYSICAL FACTORS

The article shows the opportunity of use of biomonitoring in patients with exogenous toxic encephalopathy in the remote period of chronic mercury intoxication. (CMI) and with, vibration disease caused by local vibration. The efficiency of the biofeedback method was assessed on the basis of the data of electroencephalography, auditory, visual and somatosensoric generated potentials, electroneuromyography, thermometry, dosed cold test and. rheography. Biofeedback training in people with. CMI caused decrease of total brain changes in EEG, improvement of amplitude indices at of the brain generated potentials, in people with vibration disease it caused decrease of manifestation of angiodistonic syndrome and. restoration of neuromuscular conductivity

Efficiency of “Neo inulin” in the complex treatment of patients with type 2 diabetes

Diabetes mellitus is one of the most serious medical, social, and economic health problems in all countries of the world. The incidence of diabetes mellitus in the world doubles every 10–15 years, acquiring the character of a non-infectious epidemic. Therefore, it is extremely important to search for new drugs that help normalize glycemia, prevent complications of diabetes mellitus, and improve the quality of life of patients. These drugs include “Neo inulin”, which has a hypoglycemic, antioxidant, hepatoprotective and angioprotective effect.The aim: to evaluate the effectiveness of “Neo inulin” in the complex treatment of patients with type 2 diabetes mellitus.Materials and methods. The study involved 18 women (average age – 64.5 ± 8.7 years, average weight – 77.8 ± 11.4 kg) and 3 men (average age – 54.6 ± 12.4 years, average weight – 114 ± 40.2 kg). The average duration of type 2 diabetes was 11.0 (7.0–12.0) years. “Neo inulin” was prescribed as 2 capsules per day for 12 weeks in the complex of basic diabetes therapy To assess the effectiveness of therapy, a study of the quality of life related to health, a biochemical blood test (glycated hemoglobin), a clinical minimum (CBC, OAM, ECG, blood glucose) was carried out, the functional characteristics of tissue blood flow were investigated, and the ankle-brachial index (ABI) was determined. Statistical processing of the results was carried out using the Statistica 6.0 software package (StatSoft Inc., USA). Differences were considered statistically significant at p < 0.05.Results. Statistically significant differences were revealed in the values of all scales of health-related quality of life in patients in the groups before and after treatment with “Neo Inulin”, including the total physical and mental components. An improvement in the functioning of microcirculatory regulation mechanisms was noted, which is confirmed by a statistically significant increase in ABI (1.0 and 0.8 on the right; 0.9 and 0.8 on the left, respectively; p < 0.05) and the coefficient of microcirculation variation (9.2 and 8.3, respectively; p < 0.05). In 57,1 % of cases (12 people), the level of glycated hemoglobin was normalized.Conclusion. The use of a treatment regimen that includes “Neo Inulin” improves the effectiveness of treatment and improves the quality of life of patients with type 2 diabetes mellitus

Silicoarthritis: issues of early diagnosis, prevention

Background. The severity of the course of silicosis is aggravated by the addition of complications; one of the serious and rare complication of silicosis is silicoarthritis or Kaplan’s syndrome (KS), which accounts for 0.1-0.6% of all cases of silicosis. Silicoarthritis significantly reduces the quality of the life of patients and leads to early and persistent disability.Aim. To establish the most significant methods of diagnosing silicoarthritis for early detection of the disease and prevention of complications.Materials and methods. The article presents clinical cases of silicosis and its rare complication - SC. The basis for the diagnosis of this pathology is X-ray, immunological and functional methods.Results. In patients with more than 5 years of experience exposed to aerosols of fibrogenic action, crystalline silicon dioxide, with an excess of the MPC level from 2.3 to 4 times on the basis of MSCT of the lungs, during which multiple polymorphic foci with a diameter of 2 up to 10 mm, partly merging with each other into peribronchovascular couplings, as well as perifocal areas of reduced airiness like ground glass and thickening of the axial interstitium, a diagnosis of late silicosis, stage 2 nodular form was established, the diagnosis was confirmed by biopsy data. In dynamics, after 5 years, arthralgic complaints joined. On the basis of immunological (increased TNF-alpha, IL-1b), X-ray examination (osteoarthritis of the distal and proximal interphalangeal, wrist, metatarsophalangeal joints), the diagnosis was clarified as Silicoarthritis: Kaplan’s syndrome.Conclusion. Diagnosis of silicosis and its complications at the preclinical stage in workers who have been in contact with silica dust for 5 years or more should include: MSCT of the lungs, determination of TNF-alpha, IL-1b, rheumatoid factor, and a study of respiratory function

Impact of Nordic walking on health outcomes in older women

There are a number of factors that contribute to the accelerated rate of aging, one of which is physical activity. The increasing proportion of elderly and senile people in the Russian Federation requires urgent implementation of the elderly generation subprogram within the framework of the Demography federal project. In this regard, the problems of maintaining health and the development of methodological approaches to assessing the health of people in the older age group are especially significant.Objective: evaluation of anthropometry, stabilometry and biochemical parameters in the dynamics of Nordic walking in elderly womenMaterials and methods: 30 women were examined, mean age 69.0 (63.0–71.5) years. Examination by a therapist and a neurologist, biochemical blood tests, stabilometry, anthropometry, osteodensitometry (ODM) were carried out. Training loads of Nordic walking (NW) for 3 months were carried out according to the generally accepted method 3 times a week.Results: According to the biochemical analysis of blood, a statistically significant increase in the level of phosphorus and alkaline phosphatase (AP), total protein, as well as a decrease in the level of calcium and total cholesterol were revealed. When considering anthropometry data, there was a statistically significant decrease in body weight, BMI, body fat mass according to the Durnin — Womersley method, SBP and an increase in the cardiovascular index. According to the results of computer stabilometry — a statistically significant increase in the average position of the CP in the sagittal plane with open and closed eyes.Conclusion: 1. The use of NW as a training factor to achieve active longevity in the elderly leads to an improvement in the functioning of the cardiovascular system, due to a statistically significant decrease in body weight, a decrease in SBP by an average of 15 mm Hg. art., as well as the level of total cholesterol. 2. With regular NW exercises for 3 months, the functional stability indicators in the sagittal plane are corrected both with open and closed eyes

STATE OF MINERAL BONE TISSUE DENSITY IN EMPLOYEES ATTENDING TO SEVEROMUISKI TUNNEL

The results of the examination of employees realizing the exploitation of the Severomuiski distance of railway in serving of the tunnels of the East-Siberian railway concerning studying the state of mineral bone tissue density are presented in this paper. Examined patients (66 men) were divided into two age groups — up to 50 years old. and. older than 50 years old. The double-energetic x-ray absorptiometry (osteodensitometry) was performed. The reduction in the mineral bone tissue density was found to be in both studied groups