Dynamics of Students’ Opinions in the Context of the Transition to Online Learning Based on Social Network Data

The article presents the results of the analysis of users’ sentiment in social networks, performed using big data tools. The research was aimed at developing the methodology, which enables to analyze the content of social networks, assess students’ attitude to the transition to online learning in conditions of COVID-19 pandemic, identify dynamics and main trends in student satisfaction with the quality of educational process. We explored about 2 million posts and comments posted in university social networks (more than 1000 university public pages) for the period from Sept 2020 to July 2021. Special attention was paid to the problems of communication between students and teachers, strategies to solve them, an emotional reaction. PolyAnalyst software was applied for data precleaning. It has been found that the main problem affecting the quality of education is a change in the mechanisms of interaction between students and teachers. Based on student publications in social networks, we have identified the strategies for adapting students to online learning. We came to a conclusion that teachers’ support of students is crucial in preventing and solving social and academic problems in conditions of online learning. One of the ways to improve interaction between students and teachers, raise students’ involvement is using discussion forums, chats in messengers for academic purposes, and providing teachers’ methodical support

CHANGES IN HEART RATE, HEART RATE VARIABILITY AND QT INTERVAL IN WOMEN WITH RHEUMATOID ARTHRITIS DURING RITUXIMAB TREATMENT

Rheumatoid arthritis (RA) is a proven high cardiovascular risk disease. High heart rate (HR), lower heart rate variabil- ity (HRV), and increased QT interval are considered as predictors of cardiovascular events in patients with coronary heart disease, chronic heart failure, and diabetes mellitus. In RA, there is a pronounced rise in HR, a reduction in HRV, and an increase in QT interval mainly due to the factors reflecting the severity of the disease. Rituximab (RTM) is successfully used to treat patients with high RA activity. At the same time there are only a few pieces of evidence for the effect of the drug on the cardiovascular system. Objective: to study changes in HR, HRV, and QT interval values obtained during electrocardiography (ECG) Holter monitoring (ECG HM) in RTM-treated women during a 6-month follow-up. Subjects and methods: The investigation enrolled 55 women (mean age 50 years) with a definite diagnosis of RA and its high activity. The patients were examined 6 months after administration of RTM. The latter was infused intra- venously twice (500 and 1000 mg in 22% and 78% of the patients, respectively) during therapy with disease-modifying antirheumatic and non-steroidal anti-inflammatory drugs and glucocorticoids. The RA patients were divided into two groups: 1) a satisfactory/good effect of RTM according to the EULAR criteria (n = 41); 2) no effect (n = 14). Analysis of 24-hour ECG HM yielded the values of HR and mean duration of corrected QT interval (QTc). The tim- ing HRV values obtained at ECG HM were standardized from age and mean HR (SDNNn, RMSSDn, and pNN50n). Results. The baseline HRmin and HRmean values were higher and SDNNn was lower in the RA patients in Group 1 than those in Group 2 (p < 0.05). In Group 1, RTM therapy was accompanied by a reduction in HRmean and HRmin by 8% and by an increase in SDNNn by 3%, RMSSDn by 26%, and pNN50n by 33% whereas no significant changes in HR and HRV were found in Group 2. The RTM therapy-induced HRmean decrease was associated with the reductions of C-reactive protein concentration and HAQ disability index (p < 0.01), the increases of rMSSDn and pNN50n associated with lower HAQ index, ERS, and DAS28 (p < 0.01). There were no differences in QTc in Groups 1 and 2 during 6 months after RTM therapy. Thus, effective RTM therapy is attended by reduced HR and improved HRV values

A Modern View of Anomalies in the Metal Groups of the Periodic System of D.I.Mendeleev

The article is devoted to the 150th anniversary of the Periodic Table of Chemical Elements by D.I.Mendeleev. The fundamental law of nature, discovered by D.I.Mendeleev has anomalies and paradoxes associated with certain groups of metals. When studying the physical and chemical properties of complex metal compounds, many discrepancies can be found, namely, the location of elements in groups, which primarily relate to metals with different valences. By studying the approaches and methods for predicting the arrangement of chemical elements, it can be established that D.I.Mendeleev eliminated many differences for some metals during the formation of the Periodic system of chemical elements. D.I.Mendeleev developed a principle that excludes such errors when finding and discovering new elements. Analytical studies conducted by a Russian scientist helped to calculate the atomic masses and describe the properties of three elements not known at that time – «eka-boron», «eka-silicon», «eka-aluminum», the existence of which was proved and confirmed by subsequent discoveries of scandium, germanium, boron, and gallium. The paper provides a significant assessment of the forecasting of metals in various groups of the periodic system. Changes in the properties of some metals significantly influenced their location in the table of D.I.Mendeleev

ROCK FAILURE INFLUENCE OF THE BLOCK-HIERARCHICAL STRUCTURE OF ROCKS ON THE PECULIARITIES OF SEISMIC WAVE PROPAGATION

The analysis is performed for the parameters of long pendulum-type waves in a one-dimensional periodic system with an arbitrary hierarchical structure. A case study is carried out into the wave propagation peculiarities in an impact-excited system of equal rigid blocks with parting layers differing in rigidity. The pendulum wave velocity in the automodel block-hierarchical system is determined

New advances in Raman study of polyvinylchloride structure

In this work we investigated Raman spectra of a number of industrial grades of polyvinylchloride powder and films, prepared from solutions in tetrahydrofuran and acetophenone. The number and spectral characteristics of the Raman lines in the spectral regions of the C-Cl stretching vibrations and in the region of the C-H and CH2 stretching vibrations were evaluated

The use of high resolution ECG and Heart rate variability methods in diagnosing of myocardial electrical instability in patients with acute coronary syndrome

Work is devoted to research dynamics of parameters of high resolution ECG (HRECG) and heart rate variability (HVR) methods in patients with acute coronary syndrome in determining myocardial electrical instability and disease trend the carried out. The researches have shown that, the HRECG and HRV variables in acute coronary syndrome, patients have various possible changes, which correlate with the severity of the current disease

Metabolic syndrome in rheumatoid arthritis: role of adiponectin (preliminary results)

The clinical value of the disorders and diseases integrated within the metabolic syndrome (MS) is in the combination of traditional risk factors for cardiovascular diseases (CVD), which significantly accelerates the development of cardiovascular events (CVEs). The detection rate for MS in patients with rheumatoid arthritis (RA) is shown to be higher than in the controls regardless of the diagnostic criteria for MS. At present, there are confusing data on the role of adipokins in RA. Objective: to determine the rate of MS and its components in RA patients and the association of the level of adipokin (adiponectin) with the components of MS in relation to the duration of RA. Subjects and methods: The investigation enrolled 69 RA patients divided into two groups: 1) 34 patients with early-stage (<2-year) RA and 2) 35 patients with end-stage (>2-year) RA. Results. MS occurred in 12 (17.4%) of the 69 patients with RA. There was central (abdominal) obesity in 37 (53.6%) patients with RA, hypertension in 29 (42%), low high-density cholesterol levels in 20 (29%), hyperglycemia in 11 (15.9%), and hypertriglyceridemia in 10 (14.5%). According to the presence or absence of MS, the patients were divided into 2 groups: 1) 12 patients with MS; 2) 57 without MS. In the patients with RA and MS, the duration of the disease was shorter; DAS28 and CDAI were higher than in those without MS: 15.4 [7; 24] months versus 51.8 [6; 72] months; DAS28 was 5.8 [4.9; 6.7] scores versus 5.1 [4.5; 5.8] scores; CDAI: 34.8 [21.8; 41.4] scores versus 24.2 [18; 31] scores, respectively (p < 0.05 in all cases). The serum level of adiponectin was lower: 13.1 [5.7; 10.7] ng/ml versus 20.6 [6.9; 30.9] ng/ml in the patients with RA and MS as compared to those without MS; but there were no significant differences. In the patients with early-end RA, the rate of MS was twice higher than that in those with end-stage RA; however, the differences were statistically insignificant (p = 0.1). The components of MS were encountered with the same frequency in early- and end-stage RA. The early RA group showed a correlation between SDAI (r = -0.34), body mass index (r = -0.41), high-density lipoprotein cholesterol (r = 0.33), erythrocyte sedimentation rate (r =-0.35), and adiponectin. The >2-year RA group displayed no relationship between adipokins, activity markers, and metabolic disturbances. Conclusion. The preliminary results suggest the high rate of MS in patients with a high level of early RA disease activity untreated with disease-modifying antirheumatic drugs, thus determining the high risk of CVEs just at disease onset. The role of adiponectin in the development of MS, CVEs in rheumatic diseases remains to be solved, which is the subject of further investigations. It is possible that normalization of adiponectin concentrations may promote reductions in the incidence of CVD, mortality rates due to atherosclerosis-induced CVEs, and the prevalence of MS and insulin resistance

Diagnostic methodics of personal development of university students in studying the humanities

© The author(s). The urgency of the research of diagnostic methodics of personal development of university students in studying the humanities does not lose its science - based and practice - oriented value and at the present transitional time, which has put higher education before the need to train professionals with personal qualities as required to modify the social structure of the labor market and the needs of the personality. The purpose of the article is in scientific - practical justification of the set of diagnostic methodics of personal development of students and experimental verification of their efficiency in the process of studying the humanities. The article presents: theoretical - methodic foundations of the structure, content and implementation techniques of diagnostic methodics of personal development of students in studying the humanities and identifies practical significance of the methodic for the formation of competent professionals demanded by modern job market. The leading method of this study is to monitor the personal development of university students in the process of studying the humanities. The article stuff is designed for university teachers of humanities, young scientists and students, who are interested in research activities in the humanitarian sphere. It is recommended to university methodists and students of further teacher training centers of continuing professional education