Boundary Between Stable and Unstable Regimes of Accretion

We investigated the boundary between stable and unstable regimes of accretion and its dependence on different parameters. Simulations were performed using a "cubed sphere" code with high grid resolution (244 grid points in the azimuthal direction), which is twice as high as that used in our earlier studies. We chose a very low viscosity value, with alpha-parameter alpha=0.02. We observed from the simulations that the boundary strongly depends on the ratio between magnetospheric radius r_m (where the magnetic stress in the magnetosphere matches the matter stress in the disk) and corotation radius r_cor (where the Keplerian velocity in the disk is equal to the angular velocity of the star). For a small misalignment angle of the dipole field, Theta=5 degrees, accretion is unstable if r_cor/r_m>1.35, and is stable otherwise. In cases of a larger misalignment angle of the dipole, Theta=20 degrees, instability occurs at slightly larger values, r_cor/r_m>1.41.Comment: 4 pages, 4 figures, conference proceedings: "Physics at the Magnetospheric Boundary", Geneva, Switzerland, 25-28 June, 201

MHD Simulations of Magnetospheric Accretion, Ejection and Plasma-field Interaction

We review recent axisymmetric and three-dimensional (3D) magnetohydrodynamic (MHD) numerical simulations of magnetospheric accretion, plasma-field interaction and outflows from the disk-magnetosphere boundary.Comment: 11 pages, 8 figures, conference proceedings: "Physics at the Magnetospheric Boundary", Geneva, Switzerland, 25-28 June, 201

On local anesthetic action of some dimethylacetamide compounds

The study aim was to explore local anesthetic properties of some tertiary and quaternary derivatives of dimethylacetamid

2-aminoaethanesulfonic acid compounds possess protective property in reperfusion-induced heart jnjury

The study aim was to explore pharmacological effects of 2-aminoaethansulfonic acid compounds in reperfusion-induced heart injury. The study was performed on rats and dogs of both sexes, isolated rats’ hearts. Two compounds of 2-aminoethanesulfonic acid, magnesium-containing (LBK-527) and phenylacetamide-containing (LKhT-317) were investigate

On mechanism of antiarrhythmic action of some dimethylphenylacetamide derivatives

The study aim was to identify essential elements of the antiarrhythmic action mechanism of tertiary and quaternary derivatives of Dimethylphenylacetamide. The study was conducted in albino rats and mice of both sexes; isolated neurons of mollusc Limnea stagnalis; and strips of rats’ right ventricle myocardium. Two compounds of Dimethylphenylacetamide LKhT- 3-00 and LKhT-12-02 were studie

In vitro maintaining of CD4+ central and effector memory cells in normal and inflammatory conditions

IL-7 is a key factor for the survival and maintenance of CD4+ central (Tcm) and effector (Tem) memory cells in the whole body. In many autoimmune diseases, an elevated level of IL-7 is detected in blood serum and at the site of inflammation, thus suggesting participation of this homeostatic factor in the survival of memory T cells, including auto-reactive clones, in inflammatory disorders. The aim of the study was to investigate the mechanisms of maintaining CD4+ memory T cells under normal and inflammatory conditions. We developed an in vitro model of inflammation, based on induction of pro-inflammatory cytokines, and then evaluated the effects of IL-7 upon purified sorted populations of CD4+Tcm and Tem under normal conditions and in vitro inflammatory model. IL-7 treatment promoted maintenance of CD4+Tcm phenotype in all variants of cultures. In the absence of contact with adherent cell fraction, the IL-7-induced proliferation of Tcm and Tem was slightly reduced, both under normal and inflammatory conditions, thus suggesting low sensitivity of memory T cells to contacts with MHC, and, probably, a requirement for additional signals to provide complete stimulation with IL-7. The last suggestion is also supported by data about CD127 and CD132 expression, i.e., in the absence of contact with MHC, the proportion of CD127+CD132+ cells was decreased in both subpopulations of CD4+ memory cells. Upon in vitro cultures, IL-7 contributed to decreased expression of CD127, and increased expression of CD132 on CD4+Tcm and Tem. We have evaluated the CD4+Tcm and Tem populations by affinity of T cell receptor (TCR), using the level of CD5 expression. Т cells with high TCR affinity for self-antigens are known to have higher expression of CD5. In comparison to Tem, the Tcm contained more CD5high cells. In cultures, IL-7 promoted a high level of CD5 expression on Tcm, which was comparable to levels observed in peripheral blood cells. High CD5 expression on Tem was observed after stimulation with IL-7 in the in vitro inflammatory model. In the absence of contact with MHC, the number of CD5high cells decreased among CD4+Tem and Tcm. Thus, CD4+Tcm cells with high affinity for autologous antigens are probably dependent on the presence of homeostatic factors, in particular, IL-7, and contacts with antigen-presenting cells (APCs). Under conditions of inflammation, no changes were revealed in the mechanism of maintaining CD4+Tcm, in contrast to CD4+Tem. Being less dependent on IL-7 under normal conditions, CD4+CD5highTem are accumulated in the presence of IL-7 under in vitro inflammatory conditions