88 research outputs found
The genetic basis and evolution of red blood cell sickling in deer
Crescent-shaped red blood cells, the hallmark of sickle-cell disease, present a striking departure from the biconcave disc shape normally found in mammals. Characterized by increased mechanical fragility, sickled cells promote haemolytic anaemia and vaso-occlusions and contribute directly to disease in humans. Remarkably, a similar sickle-shaped morphology has been observed in erythrocytes from several deer species, without obvious pathological consequences. The genetic basis of erythrocyte sickling in deer, however, remains unknown. Here, we determine the sequences of human β-globin orthologues in 15 deer species and use protein structural modelling to identify a sickling mechanism distinct from the human disease, coordinated by a derived valine (E22V) that is unique to sickling deer. Evidence for long-term maintenance of a trans-species sickling/non-sickling polymorphism suggests that sickling in deer is adaptive. Our results have implications for understanding the ecological regimes and molecular architectures that have promoted convergent evolution of sickling erythrocytes across vertebrates
Über das Auftreten von diploiden Megakaryoblasten, Promegakaryozyten und Megakaryozyten bei schweren Hämopathien, ein Rückgriff in die Phylogenese
Die Alius-Grignaschi-Anomalie: Der erblich-konstitutionelle Peroxydasedefekt der Neutrophilen und Monozyten
Über das Auftreten von Abbauformen der Leukocyten im strömenden Blut nach Aderlass als Ausdruck einer besonderen Konstitution
Extremely small megakaryocytes in chronic myelocytic leukemia, akute leukemia and erythroleukemia
Über die Brauchbarkeit des Colorimeters Nach Autenrieth-Königsberger für die Tryptophanbestimmung im Blutserum Mittels der Voisenetschen Reaktion
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