Universal Behavior in Large-scale Aggregation of Independent Noisy Observations

Aggregation of noisy observations involves a difficult tradeoff between observation quality, which can be increased by increasing the number of observations, and aggregation quality which decreases if the number of observations is too large. We clarify this behavior for a protypical system in which arbitrarily large numbers of observations exceeding the system capacity can be aggregated using lossy data compression. We show the existence of a scaling relation between the collective error and the system capacity, and show that large scale lossy aggregation can outperform lossless aggregation above a critical level of observation noise. Further, we show that universal results for scaling and critical value of noise which are independent of system capacity can be obtained by considering asymptotic behavior when the system capacity increases toward infinity.Comment: 10 pages, 3 figure

Understanding of BRCA VUS genetic results by breast cancer specialists.

BACKGROUND: Mainstreaming genetic medicine, increased media coverage and clinical trials for BRCA mutation carriers are leading oncologists into more patient discussions about BRCA genetic testing. BRCA variants of uncertain significance (VUS) occur in 10-20% of tests. VUS detection introduces additional uncertainty for patient and potentially clinician. We aimed to explore the ability of breast cancer specialists (BCS) in the UK to correctly respond to a VUS report. METHODS: A survey sent to 800 UK BCS collected demographics data, VUS general knowledge and interpretation and communication based on two genetics reports. A separate survey of UK clinical geneticists collected demographics data, laboratory reporting practice and methods used to clarify VUS pathogenicity including classification systems. RESULTS: Of the 155 BCS (22.5%) who completed the survey, 12% reported no genetics training. Ninety five percent referred patients for BRCA genetic tests, 71% felt unsure about the clinical implications of the test reports presented here. A VUS report from a patient with a positive family history was interpreted and theoretically communicated correctly by 94% but when presented with a different VUS report with no management guidance and negative family history, 39% did not know how to communicate this result to the patient. Geneticists reported multiple VUS classification systems; the most commonly used was word-based in 32%. CONCLUSIONS: A consistent and standardised format to report particularly VUS results across all diagnostic laboratories plus additional training of UK BCS will be necessary for effective mainstreaming of BRCA testing to the oncology clinic

Initial state maximizing the nonexponentially decaying survival probability for unstable multilevel systems

The long-time behavior of the survival probability for unstable multilevel systems that follows the power-decay law is studied based on the N-level Friedrichs model, and is shown to depend on the initial population in unstable states. A special initial state maximizing the asymptote of the survival probability at long times is found and examined by considering the spontaneous emission process for the hydrogen atom interacting with the electromagnetic field.Comment: 5 pages, 1 table. Accepted for publication in Phys. Rev.

The Nystrom plus Correction Method for Solving Bound State Equations in Momentum Space

A new method is presented for solving the momentum-space Schrodinger equation with a linear potential. The Lande-subtracted momentum space integral equation can be transformed into a matrix equation by the Nystrom method. The method produces only approximate eigenvalues in the cases of singular potentials such as the linear potential. The eigenvalues generated by the Nystrom method can be improved by calculating the numerical errors and adding the appropriate corrections. The end results are more accurate eigenvalues than those generated by the basis function method. The method is also shown to work for a relativistic equation such as the Thompson equation.Comment: Revtex, 21 pages, 4 tables, to be published in Physical Review

Initial wave packets and the various power-law decreases of scattered wave packets at long times

The long time behavior of scattered wave packets $\psi (x,t)$ from a finite-range potential is investigated, by assuming $\psi (x,t)$ to be initially located outside the potential. It is then shown that $\psi (x,t)$ can asymptotically decrease in the various power laws at long time, according to its initial characteristics at small momentum. As an application, we consider the square-barrier potential system and demonstrate that $\psi (x,t)$ exhibits the asymptotic behavior $t^{-3/2}$, while another behavior like $t^{-5/2}$ can also appear for another $\psi (x,t)$.Comment: 5 pages, 1 figur

Electrostatics in a Schwarzschild black hole pierced by a cosmic string

We explicitly determine the expression of the electrostatic potential generated by a point charge at rest in the Schwarzschild black hole pierced by a cosmic string. We can then calculate the electrostatic self-energy. From this, we find again the upper entropy bound for a charged object by employing thermodynamics of the black hole.Comment: Latex, 8 pages, 1 figure in late

Takagi-Taupin Description of X-ray Dynamical Diffraction from Diffractive Optics with Large Numerical Aperture

We present a formalism of x-ray dynamical diffraction from volume diffractive optics with large numerical aperture and high aspect ratio, in an analogy to the Takagi-Taupin equations for strained single crystals. We derive a set of basic equations for dynamical diffraction from volume diffractive optics, which enable us to study the focusing property of these optics with various grating profiles. We study volume diffractive optics that satisfy the Bragg condition to various degrees, namely flat, tilted and wedged geometries, and derive the curved geometries required for ultimate focusing. We show that the curved geometries satisfy the Bragg condition everywhere and phase requirement for point focusing, and effectively focus hard x-rays to a scale close to the wavelength.Comment: 18 pages, 12 figure

Chaotic Dynamics of N-degree of Freedom Hamiltonian Systems

We investigate the connection between local and global dynamics of two N-degree of freedom Hamiltonian systems with different origins describing one-dimensional nonlinear lattices: The Fermi-Pasta-Ulam (FPU) model and a discretized version of the nonlinear Schrodinger equation related to Bose-Einstein Condensation (BEC). We study solutions starting in the vicinity of simple periodic orbits (SPOs) representing in-phase (IPM) and out-of-phase motion (OPM), which are known in closed form and whose linear stability can be analyzed exactly. Our results verify that as the energy E increases for fixed N, beyond the destabilization threshold of these orbits, all positive Lyapunov exponents exhibit a transition between two power laws, occurring at the same value of E. The destabilization energy E_c per particle goes to zero as N goes to infinity following a simple power-law. However, using SALI, a very efficient indicator we have recently introduced for distinguishing order from chaos, we find that the two Hamiltonians have very different dynamics near their stable SPOs: For example, in the case of the FPU system, as the energy increases for fixed N, the islands of stability around the OPM decrease in size, the orbit destabilizes through period-doubling bifurcation and its eigenvalues move steadily away from -1, while for the BEC model the OPM has islands around it which grow in size before it bifurcates through symmetry breaking, while its real eigenvalues return to +1 at very high energies. Still, when calculating Lyapunov spectra, we find for the OPMs of both Hamiltonians that the Lyapunov exponents decrease following an exponential law and yield extensive Kolmogorov--Sinai entropies per particle, in the thermodynamic limit of fixed energy density E/N with E and N arbitrarily large.Comment: 29 pages, 10 figures, published at International Journal of Bifurcation and Chaos (IJBC

The self-force on a static scalar test-charge outside a Schwarzschild black hole

The finite part of the self-force on a static scalar test-charge outside a Schwarzschild black hole is zero. By direct construction of Hadamard's elementary solution, we obtain a closed-form expression for the minimally coupled scalar field produced by a test-charge held fixed in Schwarzschild spacetime. Using the closed-form expression, we compute the necessary external force required to hold the charge stationary. Although the energy associated with the scalar field contributes to the renormalized mass of the particle (and thereby its weight), we find there is no additional self-force acting on the charge. This result is unlike the analogous electrostatic result, where, after a similar mass renormalization, there remains a finite repulsive self-force acting on a static electric test-charge outside a Schwarzschild black hole. We confirm our force calculation using Carter's mass-variation theorem for black holes. The primary motivation for this calculation is to develop techniques and formalism for computing all forces - dissipative and non-dissipative - acting on charges and masses moving in a black-hole spacetime. In the Appendix we recap the derivation of the closed-form electrostatic potential. We also show how the closed-form expressions for the fields are related to the infinite series solutions.Comment: RevTeX, To Appear in Phys. Rev.

Quasiholes and fermionic zero modes of paired fractional quantum Hall states: the mechanism for nonabelian statistics

The quasihole states of several paired states, the Pfaffian, Haldane-Rezayi, and 331 states, which under certain conditions may describe electrons at filling factor $\nu=1/2$ or 5/2, are studied, analytically and numerically, in the spherical geometry, for the Hamiltonians for which the ground states are known exactly. We also find all the ground states (without quasiparticles) of these systems in the toroidal geometry. In each case, a complete set of linearly-independent functions that are energy eigenstates of zero energy is found explicitly. For fixed positions of the quasiholes, the number of linearly-independent states is $2^{n-1}$ for the Pfaffian, $2^{2n-3}$ for the Haldane-Rezayi state; these degeneracies are needed if these systems are to possess nonabelian statistics, and they agree with predictions based on conformal field theory. The dimensions of the spaces of states for each number of quasiholes agree with numerical results for moderate system sizes. The effects of tunneling and of the Zeeman term are discussed for the 331 and Haldane-Rezayi states, as well as the relation to Laughlin states of electron pairs. A model introduced by Ho, which was supposed to connect the 331 and Pfaffian states, is found to have the same degeneracies of zero-energy states as the 331 state, except at its Pfaffian point where it is much more highly degenerate than either the 331 or the Pfaffian. We introduce a modification of the model which has the degeneracies of the 331 state everywhere including the Pfaffian point; at the latter point, tunneling reduces the degeneracies to those of the Pfaffian state. An experimental difference is pointed out between the Laughlin states of electron pairs and the other paired states, in the current-voltage response when electrons tunnel into the edge. And there's more.Comment: 43 pages, requires RevTeX. The 14 figures and 2 tables are available on request at [email protected] (include mailing address