Specificities of Approaches to Anticoagulant Therapy in Comorbid Patients with Atrial Fibrillation, Diabetes Mellitus and Impaired Kidney Function

Comorbid patients with atrial fibrillation, diabetes mellitus and chronic kidney disease are at high risk of stroke. The direct oral anticoagulants are indicated for them. The choice of a drug should be based on the results of randomized clinical trials, in which the patients profile corresponds to that in the real Russian clinical practice as much as possible. Taking into account the peculiarities of comorbidity in this category of patients, the requirements for their protection should be considered comprehensively. Along with the prevention of thromboembolic complications, it is necessary that the selected direct oral anticoagulant provides a reduction in the risk of cardiovascular complications, which are typical of diabetes mellitus, and slows down the progression of renal filtration function decline. Rivaroxaban may meet these requirements; its use has significant advantage in high adherence to therapy

Arterial hypertension in tuberculosis patients: clinical course and pharmaceutical control

Aim. To access arterial hypertension (AH) prevalence, pathogenesis, and effectiveness of fixed-dose perindopril and indapamide combination in tuberculosis (TB) patients. Material and methods. In total, 489 case records of patients with TB of various localization were analyzed; 42 patients with TB and AH were examined. Dynamics of 24-hour blood pressure monitoring (BPM) parameters, left ventricular (LV) morphology and function (echocardiography data), vegetative effects on hemodynamics (heart rate variability), and endothelial function (von Willebrand factor level measurement, reactive hyperemia test) were investigated. Results. The rates of AH and TB combination were quite high. These patients were characterized by “non-dipper” and “night-peaker” 24-hour BMP profiles, hypersympathicotonia, LV remodeling, right heart hypertrophy tendency, and endothelial dysfunction. Twelve-week therapy with fixed-dose combination of perindopril (4,0 mg) and indapamide (1,25 mg) was associated with positive dynamics of pathogenetic disturbances in AH and TB patients. Conclusion. AH and TB combination negatively affects cardiovascular system. Treatment with perindopril and indapamide combination provides antihypertensive effect and normalizes main mechanisms of BP regulation