Precision or narrative medicine? Child neurology needs both!

Precision medicine aims to understand the mechanisms of diseases and to find treatments adapted to each individual or group of patients, on the basis of biological characteristics and environment. It uses new tools based on digital technologies. Narrative medicine was theorized, in the 2000s, as a reaction to the increasing technicality and the notion of a lack of human relations in care: It focuses on recognizing the essential place of the patient's experience of illness and life history in the diagnosis and management of diseases as well as in the training of caregivers. These two opposite currents are rarely considered together. In fact, they have in common the basic principle that each patient is unique, and both are often more closely intertwined than we think, especially in the field of child neurology. Five case histories and discussions presented here aim to demonstrate that combining the precision approach with the narrative approach can improve the diagnosis, treatment, classification, and understanding of neurological conditions, as well as enhance the dialog with families and make teaching more meaningful. Not only rare diseases but common problems, such as paroxysmal events, pain, epilepsy, intellectual disability, and autism spectrum disorder, are addressed from both perspectives

Recent results from the Pierre Auger Observatory

The main results from the Auger Observatory are described. A steepening of the spectrum is observed at the highest energies, supporting the expectation that above $4\times 10^{19}$ eV the cosmic ray energies are significantly degraded by interactions with the CMB photons (the GZK effect). This is further supported by the correlations observed above $6\times 10^{19}$ eV with the distribution of nearby active galaxies, which also show the potential of Auger to start the era of charged particle astronomy. The lack of observation of photons or neutrinos strongly disfavors top-down models, and these searches may approach in the long term the sensitivity required to test the fluxes expected from the secondaries of the very same GZK process. Bounds on the anisotropies at EeV energies contradict hints from previous experiments that suggested a large excess from regions near the Galactic centre or the presence of a dipolar type modulation of the cosmic ray flux.Comment: 6 p., 8 figs., proceedings of the XXIII International Conference on Neutrino Physics and Astrophysics (Neutrino 08

Focus on the impact of climate change on wetland ecosystem and carbon dynamics

The renewed growth in atmospheric methane (CH4)since 2007 after a decade of stabilization has drawn much attention to its causes and future trends. Wetlands are the single largest source of atmospheric CH4. Understanding wetland ecosystems and carbon dynamics is critical to the estimation of global CH4 and carbon budgets. After approximately 7 years of CH4 related research following the renewed growth in atmospheric CH4, Environmental Research Letters launched a special issue of research letters on wetland ecosystems and carbon dynamics in 2014. This special issue highlights recent developments in terrestrial ecosystem models and field measurements of carbon fluxes across different types of wetland ecosystems. The 14 research letters emphasize the importance of wetland ecosystems in the global CO2 and CH4 budget

Comment on "On the Origin of the Highest Energy Cosmic Rays"

We show that the photodisintegration of heavy cosmic ray nuclei with energies above 10^20 eV is dominated by interactions with photons from the cosmic microwave background radiation, rather than from infrared ones. This implies that the observed air shower events with energies 2-3 10^20 eV cannot originate from Fe nuclei coming from distances beyond 10 MpcComment: 1 page, 2 figure

On Higgs and sphaleron effects during the leptogenesis era

We discuss the effects of various processes that can be active during the leptogenesis era, and present the Boltzmann equations that take them into account appropriately. A non-vanishing Higgs number asymmetry is always present, enhancing the washout of the lepton asymmetry. This is the main new effect when leptogenesis takes place at $T>10^{12}$ GeV, reducing the final baryon asymmetry and tightening the leptogenesis bound on the neutrino masses. If leptogenesis occurs at lower temperatures, electroweak sphalerons partially transfer the lepton asymmetry to a baryonic one, while Yukawa interactions and QCD sphalerons partially transfer the asymmetries of the left-handed fields to the right-handed ones, suppressing the washout processes. Depending on the specific temperature range in which leptogenesis occurs, the final baryon asymmetry can be enhanced or suppressed by factors of order 20%--40% with respect to the case when these effects are altogether ignored.Comment: one reference adde

A new method to search for a cosmic ray dipole anisotropy

We propose a new method to determine the dipole (and quadrupole) component of a distribution of cosmic ray arrival directions, which can be applied when there is partial sky coverage and/or inhomogeneous exposure. In its simplest version it requires that the exposure only depends on the declination, but it can be easily extended to the case of a small amplitude modulation in right ascension. The method essentially combines a $\chi^2$ minimization of the distribution in declination to obtain the multipolar components along the North-South axis and a harmonic Rayleigh analysis for the components involving the right ascension direction

Can continental bogs with stand the pressure due to climate change?

Not all peatlands are alike. Theoretical and process based models suggest that ombrogenic, oligotrophic peatlands can withstand the pressures due to climate change because of the feedbacks among ecosystem production, decomposition and water storage. Although there have been many inductive explanations inferring from paleo-records, there is a lack of deductive empirical tests of the models predictions of these systems’ stability and there are few records of the changes in the net ecosystem carbon balance (NECB) of peatlands that are long enough to examine the dynamics of the NECB in relation to climate variability. Continuous measurements of all the components of the NECB and the associated general climatic and environmental conditions have been made at the Mer Bleue (MB) peatland, a large, 28 km2, 5 m deep, raised ombro-oligotrophic, shrub and Sphagnum covered bog, near Ottawa, Canada from May 1, 1998 until the present. The sixteen-year daily CO2, CH4, and DOC flux and NECB covers a wide range of variability in peatland water storage from very dry to very wet growing seasons. We used the MB data to test the extent of MB peatland’s stability and the strength of the underlying key feedback between the NECB and changes in water storage projected by the models. In 2007 we published a six-year (1999-2004) net ecosystem carbon balance (NECB) for MB of ∼22 ± 40 g C m-2 yr-1, but we have since recalculated the 1998-2004 NECB to be 32 ± 40 g C m-2 yr-1 based on a reanalyzed average NEP of 51 ± 41 g C m-2 yr-1. Over the same period the net loss of C via the CH4 and DOC fluxes were -4 ± 1 and -15 ± 3 g C m-2 yr-1. The 1998-2004 six-year MB average NECB is similar to the long-term C accumulation rate, estimated from MB peat cores, for the last 3,000 years. The post 2004 MB NEP has increased to an average of ∼96 ± 32 g C m-2 yr-1 largely to there being generally wetter growing seasons. The losses of C via DOC (18 ± 1 g C m-2 yr-1) and CH4 (7 ± 4 g C m-2 yr-1) while showing considerable year-to-year variability are not significantly different post 2004. Hence, the proportional loss of C as DOC and CH4 in the MB NECB is slightly less post-2004 than it was before 2004 though the cumulative errors preclude statistically differences. As a result the MB NECB has increased to 79 ± 29 g C m-2 yr-1 post 2004 yielding a 14 year contemporary NECB of 56 ± 36 g C m-2 yr-1, which is double the long-term accumulation rate of C. The variability in the annual NECB and growing season mean NEP for the MB bog can be explained (r2 = 0.35, p \u3c 0.01) by the variability in growing season water table depth. These results suggest the carbon balance – water table feedback is sufficient enough to create stability in continental bogs so they will withstand a considerable amount of climate change

Is the halo responsible for the microlensing events?

We discuss whether the astrophysical objects responsible for the recently reported microlensing events of sources in the Large Magellanic Cloud can be identified as the brown dwarf components of the spheroid of our galaxy, rather than the constituents of a dark baryonic halo.Comment: 10 pages, Postscript file (3 figures included). Talk given by E.R. in the 6^th Workshop on Neutrino Telescopes, Venice, February 199