Separation studies in a continuous flow fluorous biphasic system - Proof of concept

A proof of concept study was undertaken for the separation of the fluorous solvent from the organic reactants/products of a fluorous biphasic system, in the absence of fluorous modified Rh catalyst. Fast and efficient separation of the two phases was observed. The more polar products were present in the organic phase-i.e. the higher the simulated conversion level-the less was the leaching of the fluorous solvent in the organic phase. (C) 2004 Elsevier B.V. All rights reserved.</p

Separation studies in a continuous flow fluorous biphasic system - Proof of concept

A proof of concept study was undertaken for the separation of the fluorous solvent from the organic reactants/products of a fluorous biphasic system, in the absence of fluorous modified Rh catalyst. Fast and efficient separation of the two phases was observed. The more polar products were present in the organic phase-i.e. the higher the simulated conversion level-the less was the leaching of the fluorous solvent in the organic phase. (C) 2004 Elsevier B.V. All rights reserved

A continuous process concept for homogeneous catalysis in fluorous biphasic systems

A novel continuous homogeneous catalytic system for the long-term testing of hydroformylation in fluorous biphasic systems has been developed. Conversion levels up to 70 % were observed, with linear to branched product ratios being around 12, while the fluorous catalyst was successfully recycled to the reactor. Efficient stirring is essential for high conversions for minimising alkene isomerisation. Leaching of the ligand, rhodium and the fluorous solvent into the organic product phase are significant. (C) 2004 Elsevier Ltd. All rights reserved.</p

The design of a continuous reactor for fluorous biphasic reactions under pressure and its use in alkene hydroformylation

A reactor, into which all reagents can be fed continuously and from which the reaction mixture can be continuously removed to a gravity separator, where product can be continuously removed and the catalyst phase recycled to the reactor, has been constructed and used for the hydroformylation of alkenes in fluorocarbon solvents.</p

A continuous process concept for homogeneous catalysis in fluorous biphasic systems

A novel continuous homogeneous catalytic system for the long-term testing of hydroformylation in fluorous biphasic systems has been developed. Conversion levels up to 70 % were observed, with linear to branched product ratios being around 12, while the fluorous catalyst was successfully recycled to the reactor. Efficient stirring is essential for high conversions for minimising alkene isomerisation. Leaching of the ligand, rhodium and the fluorous solvent into the organic product phase are significant. (C) 2004 Elsevier Ltd. All rights reserved